So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Product Details of 84547-64-8.They published the article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: regioselective heterocyclization halovinyl ketone dimethylhydrazine; halopyrazole preparation; pyrazole halo preparation. We’ll tell you more about this compound (cas:84547-64-8).
A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.
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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics