The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.Category: amides-buliding-blocks.Kim, Hyo-Jeong; Park, Il-Hyun published the article 《Synthesis of new proton-pump inhibitors》 about this compound( cas:84547-64-8 ) in Chungnam Kwahak Yonguchi. Keywords: antiulcer agent pyrazole derivative preparation. Let’s learn more about this compound (cas:84547-64-8).
For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.
Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Category: amides-buliding-blocks require different conditions, so the reaction conditions are very important.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics