Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones.Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole.
The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.
Different reactions of this compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole require different conditions, so the reaction conditions are very important.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics