Month: April 2022

Related Products of 84547-64-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine. Author is Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N..

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole(SMILESS: CN1N=C(CCl)C=C1,cas:84547-64-8) is researched.Related Products of 73590-85-9. The article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 in relation to this compound, is published in Chungnam Kwahak Yonguchi. Let’s take a look at the latest research on this compound (cas:84547-64-8).

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 84547-64-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. published an article about the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1 ).HPLC of Formula: 84547-64-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:84547-64-8) through the article.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ) is researched.HPLC of Formula: 84547-64-8.Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. published the article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii). Keywords: regioselective heterocyclization halovinyl ketone dimethylhydrazine; halopyrazole preparation; pyrazole halo preparation. Let’s learn more about this compound (cas:84547-64-8).

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 84547-64-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors. Author is Kim, Hyo-Jeong; Park, Il-Hyun.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide, is researched, Molecular C4H6Br2N2S, CAS is 79247-77-1, about An infrared study of rotational isomerism in thiazole-2-carboxylates.Recommanded Product: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide.

Twenty-five alkyl thiazole-2-carboxylates with a range of 4- and 5-substituents were prepared through the Hantzsch synthesis. E.g., cyclocondensation reaction of (H2N)2CS with MeCOCH2Br followed by bromination, oxidation, and alkylation gave the thiazole esters I (R = Me, Et). Solutions of these esters show well resolved doublets in the carbonyl IR spectra, due to rotational isomers. The higher wave number components were assigned to the more polar carbonyl O,S-anti-s-trans rotamers and those at lower wave number to the O,S-syn-s-trans forms. Small, but systematic, differences between the Me esters were noted.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Levkovskaya, G. G.; Bozhenkov, G. V.; Malyushenko, R. N.; Mirskova, A. N. published the article 《Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones》. Keywords: chlorovinyl ketone cyclization methylhydrazine; pyrazol preparation; hydrazinium methyl chloride preparation.They researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Recommanded Product: 84547-64-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:84547-64-8) here.

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》. Authors are Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G..The article about the compound:3-(Chloromethyl)-1-methyl-1H-pyrazolecas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1).Quality Control of 3-(Chloromethyl)-1-methyl-1H-pyrazole. Through the article, more information about this compound (cas:84547-64-8) is conveyed.

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide(SMILESS: NC1=NC(C)=C(Br)S1.[H]Br,cas:79247-77-1) is researched.Synthetic Route of C34H18F16IrN4P. The article 《Synthesis, Properties, and Solar Cell Performance of Poly(4-(p-alkoxystyryl)thiazole)s》 in relation to this compound, is published in Macromolecular Chemistry and Physics. Let’s take a look at the latest research on this compound (cas:79247-77-1).

Polythiazoles (PvTzs) featuring conjugated styryl sidechains equipped with different solubilizing p-alkoxy-groups (-OR, R = n-octyl, n-dodecyl, 2-ethylhexyl, 2-hexyldecyl) is prepared by Negishi-coupling polycondensation. Soluble material with number-average mol. weights of up to Mn = 8.5 kDa (polydispersity (PDI) = 1.3, d.p. (DPn) ≈ 20) is obtained, with a head-to-tail content of the PvTzs of ≈77%, as estimated from comparison with reference polymers. The polymers exhibit optical absorption properties similar to their polythiophene analogs, while their electrochem. characterization shows a significant stabilization of their frontier orbital levels. Fluorescence measurements indicate that upon excitation of the electron rich alkoxystyryl side-chains charge transfer onto the more electron deficient polythiazole backbone occurs. This finding is corroborated by d. functional theory (DFT) calculations on oligomeric model systems, which also consistently reproduce the optical properties observed for the polymers. The potential of these materials for applications in organic electronics can be demonstrated by their use as donor materials in organic photovoltaic cells, which exhibit higher open circuit voltages (VOC, up to 0.86 V) than P3HT- or analogous polythiophene-based cells (VOC = 0.5-0.6 V).

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics