Month: April 2022

Computed Properties of C5H7ClN2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines.

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of C5H7ClN2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines.

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Synthetic Route of C5H7ClN2.They published the article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 about this compound( cas:84547-64-8 ) in Russian Journal of Organic Chemistry. Keywords: ketone chloro vinyl heterocyclization hydrazine dialkyl; pyrazole alkyl chloro preparation. We’ll tell you more about this compound (cas:84547-64-8).

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: 3-(Chloromethyl)-1-methyl-1H-pyrazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine. Author is Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N..

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of pyrazole derivatives from 1,1-dimethylhydrazine and chlorovinyl ketones, published in 2001-12-31, which mentions a compound: 84547-64-8, mainly applied to chlorovinyl ketone cyclization methylhydrazine; pyrazol preparation; hydrazinium methyl chloride preparation, Category: amides-buliding-blocks.

The reaction of accessible 2-chlorovinyl Me ketones with 1,1-dimethylhydrazine gave pyrazole derivatives in high yields. 1,1,1-Trimethylhydrazinium chloride was isolated as second product of this reaction in high yield.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Obshchei Khimii called 1,3- And 1,5-dimethylpyrazole-based syntheses. VI. Stilbene and 1,4-distyrylbenzene analogs containing 3-, 4-, and 5-pyrazolyl radicals, Author is Perevalov, V. P.; Karim, A. Kh.; Andreeva, M. A.; Rumyantseva, E. G.; Stepanov, B. I., which mentions a compound: 84547-64-8, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2, Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole.

Condensation of 4-O2NC6H4CH2CO2H with pyrazolecarboxaldehydes, followed by reduction with SnCl2, gave I (R, R1 = H, H; Me, H; H, Me). Appropriate Wittig reactions gave II (R = 1-methyl-3-pyrazolyl, 4,5-dichloro-1-methyl-3-pyrazolyl, 1-methyl-5-pyrazolyl, 4-chloro-1-methyl-5-pyrazolyl), which showed intensive blue fluorescence in PhMe solution

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kim, Hyo-Jeong; Park, Il-Hyun published an article about the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1 ).Safety of 3-(Chloromethyl)-1-methyl-1H-pyrazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:84547-64-8) through the article.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Perevalov, V. P.; Karim, A. Kh.; Andreeva, M. A.; Rumyantseva, E. G.; Stepanov, B. I. published the article 《1,3- And 1,5-dimethylpyrazole-based syntheses. VI. Stilbene and 1,4-distyrylbenzene analogs containing 3-, 4-, and 5-pyrazolyl radicals》. Keywords: pyrazolyl styrene IR fluorescence; aniline pyrazolylvinyl; nitrobenzene pyrazolylvinyl.They researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Formula: C5H7ClN2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:84547-64-8) here.

Condensation of 4-O2NC6H4CH2CO2H with pyrazolecarboxaldehydes, followed by reduction with SnCl2, gave I (R, R1 = H, H; Me, H; H, Me). Appropriate Wittig reactions gave II (R = 1-methyl-3-pyrazolyl, 4,5-dichloro-1-methyl-3-pyrazolyl, 1-methyl-5-pyrazolyl, 4-chloro-1-methyl-5-pyrazolyl), which showed intensive blue fluorescence in PhMe solution

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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》. Authors are Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun.The article about the compound:3-(Chloromethyl)-1-methyl-1H-pyrazolecas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1).HPLC of Formula: 84547-64-8. Through the article, more information about this compound (cas:84547-64-8) is conveyed.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

In some applications, this compound(84547-64-8)HPLC of Formula: 84547-64-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors, the main research direction is antiulcer agent pyrazole derivative preparation.Electric Literature of C5H7ClN2.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

In some applications, this compound(84547-64-8)Electric Literature of C5H7ClN2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics