Month: April 2022

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 84547-64-8, is researched, Molecular C5H7ClN2, about Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8, the main research direction is LY3130481 preparation AMPA receptor antagonist TARP gamma8 anticonvulsant epilepsy.Synthetic Route of C5H7ClN2.

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

The article 《Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8》 also mentions many details about this compound(84547-64-8)Synthetic Route of C5H7ClN2, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Computed Properties of C4H6Br2N2S. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide, is researched, Molecular C4H6Br2N2S, CAS is 79247-77-1, about Synthesis, Properties, and Solar Cell Performance of Poly(4-(p-alkoxystyryl)thiazole)s. Author is Jaeger, Jakob; Schraff, Sandra; Pammer, Frank.

Polythiazoles (PvTzs) featuring conjugated styryl sidechains equipped with different solubilizing p-alkoxy-groups (-OR, R = n-octyl, n-dodecyl, 2-ethylhexyl, 2-hexyldecyl) is prepared by Negishi-coupling polycondensation. Soluble material with number-average mol. weights of up to Mn = 8.5 kDa (polydispersity (PDI) = 1.3, d.p. (DPn) ≈ 20) is obtained, with a head-to-tail content of the PvTzs of ≈77%, as estimated from comparison with reference polymers. The polymers exhibit optical absorption properties similar to their polythiophene analogs, while their electrochem. characterization shows a significant stabilization of their frontier orbital levels. Fluorescence measurements indicate that upon excitation of the electron rich alkoxystyryl side-chains charge transfer onto the more electron deficient polythiazole backbone occurs. This finding is corroborated by d. functional theory (DFT) calculations on oligomeric model systems, which also consistently reproduce the optical properties observed for the polymers. The potential of these materials for applications in organic electronics can be demonstrated by their use as donor materials in organic photovoltaic cells, which exhibit higher open circuit voltages (VOC, up to 0.86 V) than P3HT- or analogous polythiophene-based cells (VOC = 0.5-0.6 V).

The article 《Synthesis, Properties, and Solar Cell Performance of Poly(4-(p-alkoxystyryl)thiazole)s》 also mentions many details about this compound(79247-77-1)Computed Properties of C4H6Br2N2S, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. published the article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》. Keywords: regioselective heterocyclization halovinyl ketone dimethylhydrazine; halopyrazole preparation; pyrazole halo preparation.They researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).SDS of cas: 84547-64-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:84547-64-8) here.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

The article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》 also mentions many details about this compound(84547-64-8)SDS of cas: 84547-64-8, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines, published in 2008-08-31, which mentions a compound: 84547-64-8, mainly applied to ketone chloro vinyl heterocyclization hydrazine dialkyl; pyrazole alkyl chloro preparation, Electric Literature of C5H7ClN2.

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

The article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 also mentions many details about this compound(84547-64-8)Electric Literature of C5H7ClN2, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Levkovskaya, G. G.; Bozhenkov, G. V.; Larina, L. I.; Mirskova, A. N. published an article about the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1 ).COA of Formula: C5H7ClN2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:84547-64-8) through the article.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

The article 《New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine》 also mentions many details about this compound(84547-64-8)COA of Formula: C5H7ClN2, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 84547-64-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about 1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines. Author is Bozhenkov, G. V.; Savosik, V. A.; Klyba, L. V.; Zhanchipova, E. R.; Mirskova, A. N.; Levkovskaya, G. G..

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

The article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 also mentions many details about this compound(84547-64-8)SDS of cas: 84547-64-8, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis, Properties, and Solar Cell Performance of Poly(4-(p-alkoxystyryl)thiazole)s》. Authors are Jaeger, Jakob; Schraff, Sandra; Pammer, Frank.The article about the compound:5-Bromo-4-methyl-thiazol-2-ylamine hydrobromidecas:79247-77-1,SMILESS:NC1=NC(C)=C(Br)S1.[H]Br).Category: amides-buliding-blocks. Through the article, more information about this compound (cas:79247-77-1) is conveyed.

Polythiazoles (PvTzs) featuring conjugated styryl sidechains equipped with different solubilizing p-alkoxy-groups (-OR, R = n-octyl, n-dodecyl, 2-ethylhexyl, 2-hexyldecyl) is prepared by Negishi-coupling polycondensation. Soluble material with number-average mol. weights of up to Mn = 8.5 kDa (polydispersity (PDI) = 1.3, d.p. (DPn) ≈ 20) is obtained, with a head-to-tail content of the PvTzs of ≈77%, as estimated from comparison with reference polymers. The polymers exhibit optical absorption properties similar to their polythiophene analogs, while their electrochem. characterization shows a significant stabilization of their frontier orbital levels. Fluorescence measurements indicate that upon excitation of the electron rich alkoxystyryl side-chains charge transfer onto the more electron deficient polythiazole backbone occurs. This finding is corroborated by d. functional theory (DFT) calculations on oligomeric model systems, which also consistently reproduce the optical properties observed for the polymers. The potential of these materials for applications in organic electronics can be demonstrated by their use as donor materials in organic photovoltaic cells, which exhibit higher open circuit voltages (VOC, up to 0.86 V) than P3HT- or analogous polythiophene-based cells (VOC = 0.5-0.6 V).

The article 《Synthesis, Properties, and Solar Cell Performance of Poly(4-(p-alkoxystyryl)thiazole)s》 also mentions many details about this compound(79247-77-1)Category: amides-buliding-blocks, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 84547-64-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity. Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

The article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 also mentions many details about this compound(84547-64-8)Related Products of 84547-64-8, you can pay attention to it, because details determine success or failure

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. Author is Gardinier, Kevin M.; Gernert, Douglas L.; Porter, Warren J.; Reel, Jon K.; Ornstein, Paul L.; Spinazze, Patrick; Stevens, F. Craig; Hahn, Patric; Hollinshead, Sean P.; Mayhugh, Daniel; Schkeryantz, Jeff; Khilevich, Albert; De Frutos, Oscar; Gleason, Scott D.; Kato, Akihiko S.; Luffer-Atlas, Debra; Desai, Prashant V.; Swanson, Steven; Burris, Kevin D.; Ding, Chunjin; Heinz, Beverly A.; Need, Anne B.; Barth, Vanessa N.; Stephenson, Gregory A.; Diseroad, Benjamin A.; Woods, Tim A.; Yu, Hong; Bredt, David; Witkin, Jeffrey M..

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

After consulting a lot of data, we found that this compound(84547-64-8)Application In Synthesis of 3-(Chloromethyl)-1-methyl-1H-pyrazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8, Author is Gardinier, Kevin M.; Gernert, Douglas L.; Porter, Warren J.; Reel, Jon K.; Ornstein, Paul L.; Spinazze, Patrick; Stevens, F. Craig; Hahn, Patric; Hollinshead, Sean P.; Mayhugh, Daniel; Schkeryantz, Jeff; Khilevich, Albert; De Frutos, Oscar; Gleason, Scott D.; Kato, Akihiko S.; Luffer-Atlas, Debra; Desai, Prashant V.; Swanson, Steven; Burris, Kevin D.; Ding, Chunjin; Heinz, Beverly A.; Need, Anne B.; Barth, Vanessa N.; Stephenson, Gregory A.; Diseroad, Benjamin A.; Woods, Tim A.; Yu, Hong; Bredt, David; Witkin, Jeffrey M., which mentions a compound: 84547-64-8, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2, HPLC of Formula: 84547-64-8.

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

After consulting a lot of data, we found that this compound(84547-64-8)HPLC of Formula: 84547-64-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics