Month: September 2022

Zhang, Mengzhu;Ge, Yunshan;Wang, Xin;Tan, Jianwei;Hao, Lijun;Xu, Hongming published 《Particulate emissions from direct-injection and combined-injection vehicles fueled with gasoline/ethanol match-blends – Effects of ethanol and aromatic compositions》. The research results were published in《Fuel》 in 2021.Reference of cis-13-Docosenamide The article conveys some information:

Gasoline direct injection (GDI) vehicles are up against the great challenge of particulate emissions, which were mandatorily constrained by the China-6 emission standard Given the worldwide fuel transition from gasoline to gasoline/ethanol blends, it is important to discuss the effects of ethanol and aromatic contents on particulate emissions of GDI vehicles. In this work, 10% volume of ethanol was added into China-6b gasoline replacing C8 (carbon atoms = 8) alkanes (E10), and the specific aromatic compounds in E10 fuels were adjusted under holding total aromatic content. As there was no limit on individual aromatic compounds in the gasoline standard, the effects of aromatic compounds were investigated over the worldwide harmonized light-duty test cycle (WLTC) with engine cold-start and hot-start at room and low temperatures For GDI vehicles, the results showed that ethanol substituting part of C8 alkanes in gasoline increased the particulate number (PN) but decreased particulate mass (PM) emissions. For vehicles using the combined port fuel injection (PFI)/GDI injection systems, the PM and PN emissions climbed. Aromatic compositions significantly impacted the particulate emissions. With the concentrations of heavy aromatics increased, PM and PN emissions of both GDI and combined-injection vehicles were shown to multiply. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Reference of cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gutierrez-Villagomez, Juan Manuel;Ramirez-Chavez, Enrique;Molina-Torres, Jorge;Vazquez-Martinez, Juan published 《From Natural to Synthetic Quorum Sensing Active Compounds: Insights to Develop Specific Quorum Sensing Modulators for Microbe-Plant Interaction》 in 2020. The article was appeared in 《ACS Symposium Series》. They have made some progress in their research.Computed Properties of C17H27NO3 The article mentions the following:

It is clear the importance of plant-microbe interactions to accomplish food safety and sustainable agriculture. Many plant-microbe interactions depend on bacterial quorum sensing (QS) systems, so the manipulation of these communication systems could be a powerful instrument to modulate plant development. The search of compounds with the capacity to modulate the microbial communication systems using docking mol. anal. methods along with chromatog. and miniaturized microbiol. techniques offers a robust tool-kit for designing and testing quorum quenching (QQ) active compounds Further, the synthesis of QQ compounds can be achieved by applying enzymic processes with the advantages of lowering costs and generating fewer byproducts. To exemplify these processes, herein, a group of natural compounds known as alkamides and piperamides were tested using mol. docking simulations to detect QQ active compounds against the CviR and LasR QS receptors of Gram-neg. bacteria. The docking results show that some alkamides and piperamides bind specifically to each of the studied QS receptors. The structural anal. of the resp. crystalized-receptor native ligand and the best-docked alkamide/piperamide was used to design acyl amide-like compounds These new acyl amide-like compounds bind more efficiently to the studied QS receptors than the native ligands, according to the docking results. The designed compounds could also potentially modulate plant-microbe interactions related to cellular processes dependent on bacterial QS. The data we describe contributes to the understanding of plant-microbe interactions and investigates methods to modulate plant-microbe interactions that can impact sustainable food production The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Computed Properties of C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rosas, Julieta;Martinez, Joel O.;Alonso, Pedro;Miranda, Rene;Velasco, Luis;Rubio-Perez, Laura;Perez, Francisco J. published 《Alternative mass spectrometry techniques for the validation of the fragmentation pattern of capsaicin and dihydrocapsaicin》. The research results were published in《Rapid Communications in Mass Spectrometry》 in 2019.Recommanded Product: N-Vanillylnonanamide The article conveys some information:

Rationale : Capsaicinoids are prevalent secondary metabolites in many natural and synthetic pharmacol. compounds To date, several soft ionization studies related to capsaicinoids have been reported; they all proposed a common fragmentation pattern based on a rearrangement of the aromatic double bonds and the fragmentation of the various positional acyl chains. However, the mechanism has never been validated by high-resolution analyses. Consequently, in this work, a validated fragmentation mechanism of the main capsaicinoids, capsaicin (1) and dihydrocapsaicin (2), is offered. Methods : In order to propose and validate a common electron ionization (EI) fragmentation mechanism for the target analytes, the following mass spectrometric methods were employed: collision-induced dissociation (CID) by means of linked scans (LS), reinforcing the methodol. by high-resolution mass spectrometry (HRMS), in addition to appropriate deuterium-labeled experiments performed using gas chromatog./mass spectrometry (GC/MS) and direct anal. in real time (DART). Results : In a first stage, a common EI fragmentation pattern comprising two pathways was proposed for compounds 1 and 2; then, the suggested mechanism was validated by CID-LS together with HRMS complemented by DART-deuterium-labeling studies. The obtained results are indicative that the corresponding mol. ions were conveniently observed, m/z 305 and m/z 307; it is worth noting that the common base peak is in correspondence with a tropylium ion derivative (m/z 137), as a consequence of a McLafferty rearrangement. In addition to these highlighted fragments, other common ions, m/z 122 and m/z 94, and their corresponding trajectory, were confirmed using the same approach. Finally, the proposed mechanism was complementarily validated by deuterium-labeling studies, taking into account the two exchangeable hydrogens present in the phenolic and the amidic moieties. Conclusions : A common validated EI fragmentation pattern for both capsaicin and dihydrocapsaicin was established using appropriated mass spectrometric methods together with convenient hydrogen/deuterium labeling. This study provides a new alternative to validate mechanisms of fragmentation of important natural products. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Recommanded Product: N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Ying;Zhang, Hua;Cui, Yan;Zheng, Yanli;Chen, Hui;Hu, Zhangli;Wu, Qingyu published 《Distinct roles of alternative oxidase pathway during the greening process of etiolated algae》 in 2021. The article was appeared in 《Science China: Life Sciences》. They have made some progress in their research.Safety of N,2-Dihydroxybenzamide The article mentions the following:

The vital function of mitochondrial alternative oxidase (AOX) pathway in optimizing photosynthesis during plant de-etiolation has been well recognized. However, whether and how AOX impacts the chloroplast biogenesis in algal cells remains unclear. In the present study, the role of AOX in regulating the reassembly of chloroplast in algal cells was investigated by treating Auxenochlorella protothecoides with salicylhydroxamic acid (SHAM), the specific inhibitor to AOX, in the heterotrophy to autotrophy transition process. Several lines of evidences including delayed chlorophyll accumulation, lagged reorganization of chloroplast structure, altered PSI/PSII stoichiometry, and declined photosynthetic activities in SHAM treated cells indicated that the impairment in AOX activity dramatically hindered the development of functioning chloroplast in algal cells. Besides, the cellular ROS levels and antioxidant enzymes activities were increased by SHAM treatment, and the perturbation on the balance of NAD⁺/NADH and NADP⁺/NADPH ratios was also observed in A. protothecoides lacking AOX activity, indicating that AOX was essential in promoting ROS scavenging and keeping the redox homeostasis for algal chloroplast development during greening. Our study revealed the essentiality of mitochondrial AOX pathway in sustaining algal photosynthetic performance and provided novel insights into the physiol. roles of AOX on the biogenesis of photosynthetic organelle in algae.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Safety of N,2-Dihydroxybenzamide This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Miao, Yongchao;Wen, Shuming;Feng, Qicheng;Liao, Runpeng published 《Enhanced adsorption of salicylhydroxamic acid on ilmenite surfaces modified by Fenton and its effect on floatability》 in 2021. The article was appeared in 《Colloids and Surfaces, A: Physicochemical and Engineering Aspects》. They have made some progress in their research.Name: N,2-Dihydroxybenzamide The article mentions the following:

This work reports a new method of using Fenton to oxidize and modify the ilmenite surface using salicylhydroxamic acid (SHA) as the collector. The activation mechanism of this process was studied by analyzing changes that occurred on the ilmenite surface. Micro-flotation showed that the maximum recovery of ilmenite after treatment with Fenton increased by 37% and attributed to the increase in the adsorbed SHA amount on the ilmenite surface. Zeta potential and XPS measurement data showed that Fenton promoted the conversion of Fe2+→Fe3+ on the ilmenite surface that enhanced SHA adsorption. After adding Fenton, the Fe-SHA complex (formed in the pulp) interacted with the O sites of ilmenite surfaces, and improved the ilmenite floatability. The IR spectra of the ilmenite+Fenton+SHA system showed several intense bands that indicated enhanced SHA chemisorption on the ilmenite surface. Thus, ilmenite treatment with the Fenton promoted its surface reactivity caused SHA to bind with the ilmenite surface and enhanced the ilmenite floatability.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Name: N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ali, Iftikhar;Ali, Muhammad;Shareef, Huma;Naeem, Sadaf;Khadim, Adeeba;Ali, Meher;Amber, Faiza;Hussain, Hidayat;Ismail, Muhammad;Shah, Syed Tasadaque A.;Noor, Ali;Wang, Daijie published 《Phytochemical analysis and biological activities of “Cherchoomoro” (Nepeta adenophyta Hedge)》. The research results were published in《Journal of Ethnopharmacology》 in 2021.Recommanded Product: cis-13-Docosenamide The article conveys some information:

Nepeta adenophyta Hedge (Lamiaceae) is an endemic therapeutic herb from Astore, Gilgit (Pakistan). This plant species has been reported among the local communities, especially for treating abdominal pain, kidney pain, menstrual pain, headache, and controlling bleeding disorders. Therefore, the scientific basis is provided for the relief of pain as it is used in various pain management among the natives, especially as ethnogynecol. herbal remedy. The present study investigates the analgesic and anti-inflammatory effects of the ethanolic extract of N. adenophyta in animal models. Furthermore, the extract was also studied to determine their valuable phytoconstituents. The biol. effects were determined via tail-flick, hot plate, and acetic-acid-induced abdominal writhing methods. At the same time, anti-inflammatory activity was assesed via oxidative burst and antioxidant DPPH assay. Gas chromatog.-mass spectrometry (GC-MS), and liquid chromatog.-mass spectrometry (LC-MS) techniques were employed to understand the phytochems. present in the crude ethanolic extract of Nepeta adenophyta. In the current study, Nepeta adenophyta extract exhibited potent analgesic and anti-inflammatory effects on different pain models and indicated that the analgesic effect of N. adenophyta extract is mediated both in central and peripheral ways. Dose-dependent and significant (P < 0.05) increases were shown in pain threshold, at 45 min post-treatment, with 20 and 40 mg/kg of the extract in the tail-flick model. The effects of the extract were similar to aspirin but lower to those by morphine (2.5 mg/kg) in the same tests. The extract (20-40 mg/kg) showed dose-dependent inhibition of writhing with a significant (P < 0.001) increase protection against thermal stimuli in hot plate test as compared to control and similar to aspirin and morphine. Further, the anti-inflammatory activity of the crude in oxidative burst and DPPH assays showed significant inhibitory activity. The chem. profile anal. showed major phytochems., including long chain derivatives of alkane and alc., phenolics, naphthalene, naphthopyran, androsten phenanthrenone, nepetalactones, flavonoids etc. Nepeta adenophyta Hedge is suggested as a natural alternative for mild pain relief. Our findings endorse the folklore use of N. adenophyta in different pain managements which can be attributed to the presence of polyphenolic compounds, naphthalene derivatives, flavanoids and nepetalactones etc. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Recommanded Product: cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Knolhoff, Ann M.;Premo, Jacob H.;Fisher, Christine M. published 《A Proposed Quality Control Standard Mixture and Its Uses for Evaluating Nontargeted and Suspect Screening LC/HR-MS Method Performance》. The research results were published in《Analytical Chemistry (Washington, DC, United States)》 in 2021.HPLC of Formula: 112-84-5 The article conveys some information:

Nontargeted (NTA) and suspect screening analyses (SSA) aim to detect and identify unknown compounds of interest from a given sample. The complexity and diversity of NTA and SSA methodologies necessitate the use of a comprehensive quality control standard mixture to determine if methods are fit for purpose, but to our knowledge, such a standard has not been developed that can be used by multiple disciplines, nor is one readily available. This work describes the development and anal. of a proposed nontargeted standard/quality control mixture for NTA and SSA applications using liquid chromatog./electrospray ionization-high resolution-mass spectrometry. Considerations in its development included achieving diversity of compounds with respect to elemental composition, mol. weight, retention time, and ionization in pos. and/or neg. ion modes, which resulted in the inclusion of 89 compounds The utility of the standard mixture was applied on our own NTA and SSA workflows where sample preparation efficiency and potential sources of error due to instrumental and data processing methods were evaluated. Some areas in need of improvement were identified, such as hydrophilic compound detection and mol. formula generation for compounds containing fluorine. However, our overall methodol. was found to be fit for purpose and we were able to establish thresholds to increase reliability and throughput of reported results. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.HPLC of Formula: 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Huang, He;Yuan, Min;Seitzer, Phillip;Ludwigsen, Susan;Asara, John M. published 《IsoSearch: an untargeted and unbiased metaboliteand lipid isotopomer tracing strategy fromHR-LC-MS/MS datasets》. The research results were published in《Methods and Protocols》 in 2020.Recommanded Product: 6-Aminonicotinamide The article conveys some information:

Stable isotopic tracer anal. is a technique used to determine carbon or nitrogen atom incorporation into biol. systems. A number of mass spectrometry based approaches have been developed for this purpose, including high-resolution tandem mass spectrometry (HR-LC-MS/MS), selected reaction monitoring (SRM) and parallel reaction monitoring (PRM). We have developed an approach for analyzing untargeted metabolomic and lipidomic datasets using high-resolution mass spectrometry with polarity switching and implemented our approach in the open-source R script IsoSearch and in Scaffold Elements software. Using our strategy, which requires an unlabeled reference dataset and isotope labeled datasets across various biol. conditions, we traced metabolic isotopomer alterations in breast cancer cells (MCF-7) treated with the metabolic drugs 2-deoxy-glucose, 6-aminonicotinamide, compound 968, and rapamycin. Metabolites and lipids were first identified by the com. software Scaffold Elements and LipidSearch, then IsoSearch successfully profiled the 13C-isotopomers extracted metabolites and lipids from 13C-glucose labeled MCF-7 cells. The results interpreted known models, such as glycolysis and pentose phosphate pathway inhibition, but also helped to discover new metabolic/lipid flux patterns, including a reactive oxygen species (ROS) defense mechanism induced by 6AN and triglyceride accumulation in rapamycin treated cells. The results suggest the IsoSearch/Scaffold Elements platform is effective for studying metabolic tracer anal. in diseases, drug metabolism, and metabolic engineering for both polar metabolites and non-polar lipids. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Recommanded Product: 6-Aminonicotinamide induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Xue-Chao;Canellas, Elena;Dreolin, Nicola;Goshawk, Jeff;Nerin, Cristina published 《A Collision Cross Section Database for Extractables and Leachables from Food Contact Materials》. The research results were published in《Journal of Agricultural and Food Chemistry》 in 2022.HPLC of Formula: 112-84-5 The article conveys some information:

The chems. in food contact materials (FCMs) can migrate into food and endanger human health. In this study, we developed a database of traveling wave collision cross section in nitrogen (^TWCCS_N2) values for extractables and leachables from FCMs. The database contains a total of 1038 ^TWCCS_N2 values from 675 standards including those commonly used additives and nonintentionally added substances in FCMs. The ^TWCCS_N2 values in the database were compared to previously published values, and 85.7, 87.7, and 64.9% [M + H]⁺, [M + Na]⁺, and [M – H]^– adducts showed deviations <2%, with the presence of protomers, post-ion mobility spectrometry dissociation of noncovalent clusters and inconsistent calibration are possible sources of CCS deviations. Our exptl. ^TWCCS_N2 values were also compared to CCS values from three prediction tools. Of the three, CCSondemand gave the most accurate predictions. The ^TWCCS_N2 database developed will aid the identification and differentiation of chems. from FCMs in targeted and untargeted anal. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.HPLC of Formula: 112-84-5 It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vimercati, Claudio;Qanud, Khaled;Mitacchione, Gianfranco;Sosnowska, Danuta;Ungvari, Zoltan;Sarnari, Roberto;Mania, Daniella;Patel, Neel;Hintze, Thomas H.;Gupte, Sachin A.;Stanley, William C.;Recchia, Fabio A. published 《Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart》 in 2014. The article was appeared in 《American Journal of Physiology》. They have made some progress in their research.Name: 6-Aminonicotinamide The article mentions the following:

In vitro studies suggested that glucose metabolism through the oxidative pentose phosphate pathway (oxPPP) can paradoxically feed superoxide-generating enzymes in failing hearts. We therefore tested the hypothesis that acute inhibition of the oxPPP reduces oxidative stress and enhances function and metabolism of the failing heart, in vivo. In 10 chronically instrumented dogs, congestive heart failure (HF) was induced by high-frequency cardiac pacing. Myocardial glucose consumption was enhanced by raising arterial glycemia to levels mimicking postprandial peaks, before and after i.v. administration of the oxPPP inhibitor 6-aminonicotinamide (80 mg/kg). Myocardial energy substrate metabolism was measured with radiolabeled glucose and oleic acid, and cardiac 8-isoprostane output was used as an index of oxidative stress. A group of five chronically instrumented, normal dogs served as control. In HF, raising glycemic levels from ∼80 to ∼170 mg/dL increased cardiac isoprostane output by approx. twofold, whereas oxPPP inhibition normalized oxidative stress and enhanced cardiac oxygen consumption, glucose oxidation, and stroke work. In normal hearts glucose infusion did not induce significant changes in cardiac oxidative stress. Myocardial tissue concentration of 6P-gluconate, an intermediate metabolite of the oxPPP, was significantly reduced by ∼50% in treated vs. nontreated failing hearts, supporting the inhibitory effect of 6-aminonicotinamide. Our study indicates an important contribution of the oxPPP activity to cardiac oxidative stress in HF, which is particularly pronounced during common physiol. changes such as postprandial glycemic peaks. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Name: 6-Aminonicotinamide is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide also reduces cardiovascular oxidative injury following ischemia/reperfusion.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics