Month: September 2022

Zinner, Christoph;Holmberg, Hans-Christer;Sperlich, Billy published 《Topical application of cream containing nonivamide and nicoboxil does not enhance the performance of experienced cyclists during a 4-km time-trial》 in 2016. The article was appeared in 《European Journal of Applied Physiology》. They have made some progress in their research.Name: N-Vanillylnonanamide The article mentions the following:

Purpose: Topical application of nonivamide-nicoboxil cream to resting legs has been shown to enhance the level of oxygenated Hb in leg muscles 15 min later. Here, we examined whether such application improves the performance of experienced cyclists in a subsequent 4-km time-trial. Methods: Nine male cyclists [26 ± 8 years; 176 ± 9 cm; 73.5 ± 12.8 kg; peak oxygen uptake: 50.7 ± 4.0 mL min^-1 kg^-1 (mean ± SD)] performed three 4-km time-trials on an ergometer with either topical application of nonivamide-nicoboxil cream (CREAM) or cream without active components (SHAM) to both their thigh muscles or no application (CONTROL). Results: Only the skin temperature immediately before and after the time-trial was higher with cream than SHAM and CONTROL (best p < 0.001, best d = 1.16). All other parameters evaluated, i.e., the average power output during the time-trial (p > 0.05, best d = 0.08), the tissue saturation index of the m. vastus lateralis (p > 0.05, best d = 0.57), cardiac output, heart rate, oxygen uptake, blood lactate concentration, and perceived exertion (p > 0.05, best d = 1.1) were similar under all three conditions. Conclusions: Our present findings reveal that topical application of cream containing nonivamide and nicoboxil to the thighs of cyclists prior to a 4-km time-trial does not improve their power output, saturation of the m. vastus lateralis with oxygen, oxygen uptake, heart rate, cardiac parameters, or perceived level of exertion. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Name: N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Noh, Kwanghae;Fincher, Jason;Mimms, Robert;Sue, Hung-Jue published 《Effect of mold temperature and additive migration on scratch behavior of TPOs at elevated temperatures》 in 2021. The article was appeared in 《Polymer》. They have made some progress in their research.Product Details of 112-84-5 The article mentions the following:

Scratch performance of thermoplastic olefins (TPOs) has been considered one of the required properties for automotive applications. The scratch resistance of TPOs can be enhanced by utilization of commonly used slip additives such as erucamide. When TPOs are injection molded, the mold temperature impacts the migration of the slip additive toward the surface and the surface crystallinity of the TPOs, which has been shown to influence scratch resistance. In order to evaluate the effect of the mold temperature and erucamide migration on scratch behavior at elevated temperatures, this research has adopted the ASTM D7027/ISO 19252 linearly increasing normal load scratch test methodol. to investigate the scratch behavior of the model TPOs at 25°C, 50°C, and 75°C. This study provides a comprehensive understanding on the effects of mold temperature, slip additive, elevated testing temperature, and thermal aging on scratch behavior of TPOs.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 112-84-5In 2021, Younis, Waqas;Alamgeer;Schini-Kerth, V. B.;Junior, Arquimedes Gasparotto;Nocchi, Samara Requena;Silva, Denise Brentan;Roberts, Richard E. published 《Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery》. 《Journal of Ethnopharmacology》published the findings. The article contains the following contents:

Asphodelus tenuifolius Cav. (Asphodelaceae), a wild, terrestrial, annual stemless herb, is widely used in traditional medicine for the treatment of hypertension, diabetes, atherosclerosis and circulatory problems. A previous research study from our laboratory revealed that A. tenuifolius has beneficial effects in reducing blood pressure and improves aortic endothelial dysfunction in chronically glucose fed rats. Despite the fact that A. tenuifolius reduces blood pressure and improves endothelial function in vivo, there are no detailed studies about its possible mechanism of action. This study was designed to provide pharmacol. basis and mechanism of action for the traditional use of A. tenuifolius in hypertension and circulatory problems. We explored the vasorelaxant effect of A. tenuifolius and its underlying vasorelaxation mechanism in porcine coronary artery rings. Aqueous methanolic crude extract of A. tenuifolius was prepared by maceration process and then activity guided fractionation was carried out by using different polarity based solvents. Phytochem. studies were carried out using LC-DAD-MS. Segments of porcine distal coronary artery were set up in a wire myograph for isometric force measurements. Extract/fractions of A. tenuifolius seeds were tested for vasodilator activity by measurement of changes in tone after pre-contraction with the thromboxane mimetic U46619 in the presence or absence of inhibitors of intracellular signaling cascades.Crude extract/fractions of A. tenuifolius produced dose dependent endothelium independent vasorelaxant response in coronary rings, whereas, the butanol fraction of A. tenuifolius (BS-AT) produced the largest relaxation response with 100% relaxation at 1 mg/mL, therefore the mechanism of relaxation of this fraction was determined The relaxation to BS-AT was unaffected by removal of the endothelium, pre-contraction with KCl, or the presence of the non-selective potassium channel blocker tetraethylammonium, indicating that the relaxation was endothelium-independent, and does not involve activation of potassium channels. BS-AT (1 mg/mL) inhibited the contractile response to calcium, the L-type calcium channel activator BAY K8664,and ionomycin, indicating that it inhibits calcium-induced contractions. The relaxation response to BS-AT was attenuated in the absence of extracellular calcium. However, relaxations to BS-AT were also reduced after deletion of calcium from intracellular stores with cyclopiazonic acid. Incubation with 1 mg/mL BS-AT also inhibited phosphorylation of myosin light chains in homogenates of coronary artery. The butanol extract of Asphodelus tenuifolius produces a large endothelium-independent relaxation of the porcine coronary artery through inhibition of calcium-induced contractions. The effect appears to be downstream of calcium influx, possibly through inhibition of myosin light chain kinase. This study supports previous studies demonstrating that A. tenuifolius reduces blood pressure. Future studies will aim to determine the active compounds underlying this response. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.SDS of cas: 112-84-5 It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rashwan, Hanan M.;Mohammed, Hagar E.;El-Nekeety, Aziza A.;Hamza, Zeinab K.;Abdel-Aziem, Sekena H.;Hassan, Nabila S.;Abdel-Wahhab, Mosaad A. published 《Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity in rats》. The research results were published in《Environmental Science and Pollution Research》 in 2021.Recommanded Product: 112-84-5 The article conveys some information:

This study was conducted to identify the bioactive phytochems. in Salvia officinalis essential oil, to determine the polyphenols in the aqueous extract (SOE), and to evaluate their protective role against cadmium (Cd)-induced oxidative damage and genotoxicity in rats. Six groups of female rats were treated orally for 2 wk including the control group, CdCl2-treated group, SOE-treated groups at low or high dose (100 and 200 mg/kg b.w), and CdCl2 plus SOE-treated groups at the two doses. The GC-MS anal. identified 39 compounds; the main compounds were 9-octadecenamide, eucalyptol, palmitic acid, and oleic acid. However, the HPLC anal. showed 12 polyphenolic compounds and the majority were coumaric acid, chlorogenic acid, coffeic acid, catechin, vanillin, gallic acid, ellagic acid, and rutin. In the biol. study, rats received CdCl2 displayed severe disturbances in liver and kidney indexes alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb), total protein (TP), total bilirubin (T. Bil), direct bilirubin (D. Bil), creatinine, uric acid, and urea, lipid profile, tumor necrosis factor-alpha (TNF-α), alpha-fetoprotein (AFP) and CEA), glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), malondialdehyde (MDA), nitric oxide (NO), gene expressions, DNA fragmentation, and histol. alterations in the liver and kidney tissue. SOE showed a potent antioxidant and mitigated these alterations in serum and tissue. Moreover, the high dose succeeded to normalize most of the tested parameters and histol. features. It could be concluded that S. officinalis is a promising source for bioactive compounds with therapeutic benefits against environmental toxicants.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Recommanded Product: 112-84-5 It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 2444-46-4《Direct arene C-H fluorination with ¹⁸F^– via organic photoredox catalysis》 was published in 2019. The authors were Chen, Wei;Huang, Zeng;Tay, Nicholas E. S.;Giglio, Benjamin;Wang, Mengzhe;Wang, Hui;Wu, Zhanhong;Nicewicz, David A.;Li, Zibo, and the article was included in《Science (Washington, DC, United States)》. The author mentioned the following in the article:

Positron emission tomog. (PET) is a widely used imaging technique for medical diagnostics and pharmaceutical development. As the name implies, it requires tracers that emit positrons, typically through labeling with fluorine or carbon radioisotopes. W. Chen et al. devised a versatile technique to incorporate radioactive fluoride into aromatic rings. The metal-free photochem. method directly substitutes aryl carbon-hydrogen bonds with [¹⁸F]fluoride and so is particularly well suited to late-stage transformation of complex mols. into tracers. Science, this issue p. 1170. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rauguth, Andreas;Kredel, Alexander;Carrella, Luca M.;Rentschler, Eva published 《3d/4f Sandwich Complex Based on Metallacrowns》. The research results were published in《Inorganic Chemistry》 in 2021.COA of Formula: C7H7NO3 The article conveys some information:

A novel lanthanide double-decker complex with nickel metallacrowns (MCs) as coordinating ligands has been synthesized. In the 3d/4f metallacrown complex Tb^III[12-MC_Ni^IIN(shi)-4]₂, the central lanthanide ion is sandwiched between two [12-MC-4] units, forming an almost ideal square-antiprismatic coordination sphere. The resulting zenithal angles at the central lanthanide ion are smaller than those for previously reported sandwich compounds Magnetic measurements reveal an energy barrier of 346 K under zero field and up to 585 K under 3200 Oe, the highest reported for metallacrowns with D_4d symmetry. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. COA of Formula: C7H7NO3 The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 329-89-5In 2017, Gorgun, Murat F.;Zhuo, Ming;Englander, Ella W. published 《Erratum to: Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage [Erratum to document cited in CA168:230203]》. 《Molecular Neurobiology》published the findings. The article contains the following contents:

In the original publication, At Fig. 3, the image under “cisplatin + meclizine and NF200” is missing on the online published paper both in the pdf and HTML version of this article; the correction is provided here. And 6-Aminonicotinamide (cas: 329-89-5) was used in the research process.

6-Aminonicotinamide (cas:329-89-5)SDS of cas: 329-89-5 is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 112-84-5In 2022, Dattilo, Sandro;Gugliuzzo, Chiara;Mirabella, Emanuele F.;Puglisi, Concetto;Scamporrino, Andrea A.;Zampino, Daniela C.;Samperi, Filippo published 《Characterization of VOCs and additives in Italian PET bottles and studies on potential functional aldehydes scavengers》. 《European Food Research and Technology》published the findings. The article contains the following contents:

This study focused on characterization of Volatile Organic Compounds (VOCs) as contaminants and non-volatile additives in Italian PET bottles, also suggesting potential functional aldehydes scavengers. Several VOCs, such as acetic aldehyde (AA), butanal, 3-Me butanal, 1,3-dioxolane, pentanal, hexanal, octanal, 5-hepten-2-one, nonanal, and decanal, were identified by Head Space-Gas Chromatog./Mass Spectrometry (HS-GC/MS) in the PET bottles used for the packaging of six Italian brands mineral waters. AA, 1,3-dioxolane, octanal, 5-hepten-2-one, nonanal, and decanal were the most abundant compounds identified. These contaminants were also identified in the PET-bottled mineral waters. Different experiments using bottle-grade PET pellets (Btlg-PET) and PET bottles′ fragments with and without the addition of epoxidized soybean oil (ESBO) or erucamide as lubricant/plasticizer additives, poly(m-xylene adipamide) (MXD6), and/or anthranilamide (2-aminobenzamide) as potential aldehydes scavengers were carried out. Mostly VOCs observed in the PET bottles analyzed were identified in a neat ESBO sample. The presence of the ESBO additive in the PET-bottle fragments was also observed by matrix-assisted laser desorption/ionization time of flight mass spectrometry anal. (MALDI-TOF MS). The ESBO sub-products were not observed in the virgin btlg-PET pellets analyzed by both HS-GC/MS and MALDI-TOF MS. These results suggest that the VOCs come from an ESBO additive probably loaded during the blow-molding processes used for the manufacturing of PET bottles. Further studies established that MXD6 (1%w), an efficient oxygen scavenger, could be also used as AA scavenger even in the presence of the commonly used anthranilamide.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Product Details of 112-84-5 It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Luo, Yin;Tang, Haishuang;Zhang, Zhaolong;Zhao, Rui;Wang, Chuanchuan;Hou, Wenguang;Huang, Qinghai;Liu, Jianmin published 《Pharmacological inhibition of epidermal growth factor receptor attenuates intracranial aneurysm formation by modulating the phenotype of vascular smooth muscle cells》 in 2022. The article was appeared in 《CNS Neuroscience & Therapeutics》. They have made some progress in their research.Name: N,2-Dihydroxybenzamide The article mentions the following:

To study the effect of pharmacol. inhibition of epidermal growth factor receptor (EGFR) on intracranial aneurysm (IA) initiation. Human IA samples were analyzed for the expression of p-EGFR and alpha smooth muscle actin (α-SMA) by immunofluorescence (IF). Rat models of IA were established to evaluate the ability of the EGFR inhibitor, erlotinib, to attenuate the incidence of IA. We analyzed anterior cerebral artery tissues by pathol. and proteomic detection for the expression of p-EGFR and relevant proteins, and vessel casting was used to evaluate the incidence of aneurysms in each group. Rat vascular smooth muscle cells (VSMCs) and endothelial cells were extracted and used to establish an in vitro co-culture model in a flow chamber with or without erlotinib treatment. We determined p-EGFR and relevant protein expression in VSMCs by immunoblotting anal. Epidermal growth factor receptor activation was found in human IA vessel walls and rat anterior cerebral artery walls. Treatment with erlotinib markedly attenuated the incidence of IA by inhibiting vascular remodeling and pro-inflammatory transformation of VSMC in rat IA vessel walls. Activation of EGFR in rat VSMCs and phenotypic modulation of rat VSMCs were correlated with the strength of shear stress in vitro, and treatment with erlotinib reduced phenotypic modulation of rat VSMCs. In vitro experiments also revealed that EGFR activation could be induced by TNF-α in human brain VSMCs. These results suggest that EGFR plays a critical role in the initiation of IA and that the EGFR inhibitor erlotinib protects rats from IA initiation by regulating phenotypic modulation of VSMCs. The experimental procedure involved many compounds, such as N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Name: N,2-Dihydroxybenzamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics