Month: September 2022

SDS of cas: 89-73-6《Significance of dimeric surfactant on kinetic study of organophosphorus compounds》 was published in 2022. The authors were Lakra, Jyotsna;Tikariha, Deepti;Kumar, Birendra, and the article was included in《International Journal of Chemical Kinetics》. The author mentioned the following in the article:

Dimeric surfactants have shown significant role on hydrolysis of organo-phosphorus compounds In this study, we have studied the kinetic hydrolysis of p-nitrophenyl acetate (PNPA), p-nitrophenyl benzoate (PNPB), and p-dinitrophenyl di-Ph phosphate (PNPDPP) in presence of novel dimeric surfactants 12-4-12, 2Br- (butanediyl-1,4-bis(dimethyldodecylammonium bromide)), 12-4(OH)-12, 2Br- (2-butanol-1,4-bis(dimethyldodecylammonium bromide)) with conventional nucleophiles, benzohydroxamic acid (BHA), and salicylhydroxamic acid (SHA) by spectrophotometry at 27°C. Kinetic study on effect of micelles on reaction rates have been investigated and rationalization effects of micelles determination using kinetic model. The exptl. kinetic data were fitted with micellar pseudophase model for determination micellar substrate binding and parameters. The second order rate constant is processed for comparing the reactivities in aqueous and micellar pseudophase. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. SDS of cas: 89-73-6 The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Yongkang;Chi, Shuyan;Zhang, Shuang;Dong, Xiaohui;Yang, Qihui;Liu, Hongyu;Tan, Beiping;Xie, Shiwei published 《Evaluation of Methanotroph (Methylococcus capsulatus, Bath) bacteria meal on body composition, lipid metabolism, protein synthesis and muscle metabolites of Pacific white shrimp (Litopenaeus vannamei)》. The research results were published in《Aquaculture》 in 2022.COA of Formula: C22H43NO The article conveys some information:

A feeding trial was conducted to evaluate a new dietary protein Methanotroph (Methylococcus capsulatus, Bath) bacteria meal (BPM) on nutritional profile of Litopenaeus vannamei. The basal diet was formulated to contain 25% fish meal and then 15%, 30% and 45% of fish meal protein were replaced with BPM in three exptl. diets, which were labeled FM, BPM15, BPM30, and BPM45, resp. A total of 480 uniform-sized shrimp were equally distributed to four groups with three replicates and fed exptl. diets four times daily for seven weeks. Results showed that dietary BPM had no significant effect on the growth performance of shrimp (P > 0.05) but significantly reduced the crude lipid content of the whole body in shrimp fed the BPM30 diet compared to the FM diet (P < 0.05). Total cholesterol and triglyceride in the hemolymph fell significantly with the increase BPM substitution (P < 0.05). Expression of fas (fatty acid synthetase) significantly decreased with increasing BPM substitution, but the expression of cpt-1 (carnitine palmitoyltransferase) significantly increased in shrimp fed BPM30 (P < 0.05). Expression of tor (target of rapamycin) significantly decreased in hepatopancreas, while an opposite change was exhibited in the intestine of shrimp fed BPM45 (P < 0.05). Results of metabolomics indicated that dietary BPM affected the TCA cycle, ascorbate and aldarate metabolism, and glutathione metabolism in shrimp. In conclusion, BPM is an alternative to FM as a novel protein source for shrimp feed, but the changes in whole body composition, lipolysis and fatty acid synthesis, and protein synthesis and muscle metabolites of L.vannamei are noted.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.COA of Formula: C22H43NO It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xin, Qi;Yuan, Miaomiao;Li, Huanping;Song, Xiaoxia;Lu, Jun;Jing, Tao published 《In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis》. The research results were published in《Veterinary Research》 in 2020.Reference of 6-Aminonicotinamide The article conveys some information:

Abstract: Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Reference of 6-Aminonicotinamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N′Diaye, Katharina;Debong, Marcel;Behr, Juergen;Dirndorfer, Sebastian;Duggan, Tara;Beusch, Anja;Schlagbauer, Verena;Dawid, Corinna;Loos, Helene M.;Buettner, Andrea;Lang, Roman;Hofmann, Thomas published 《Dietary Piperine is Transferred into the Milk of Nursing Mothers》. The research results were published in《Molecular Nutrition & Food Research》 in 2021.Electric Literature of C17H27NO3 The article conveys some information:

The diet of breastfeeding mothers could bring nurslings into contact with flavor compounds putatively contributing to early sensory programming of the infant. The study investigates whether tastants from a customary curry dish consumed by mothers are detectable in their milk afterwards and can be perceived by the infant. Sensory evaluation identifies pungency as the dominating taste impression of the curry dish. Its ingredients of chili, pepper, and ginger suggest the flavor compounds capsaicin, piperine, and 6-gingerol as anal. targets. Breastfeeding mothers are recruited for an intervention trial involving the consumption of the curry dish and subsequent collection of milk samples for flavor compound anal. Targeted and untargeted mass spectrometric (MS)- investigations identify exclusively piperine as an intervention-derived compound in human milk. However, concentrations are below the human taste threshold. Piperine from pepper-containing foods transfers into the mothers milk within 1 h and is delivered to the nursling. Concentrations of 50 and 200 nM of piperine are 70-350 times below the human taste threshold, but TRPV1 (Transient Receptor Potential Vanilloid-1 ion channel) desensitization through frequent exposure to sub-taste-threshold concentrations could contribute to an increased tolerance at a later age. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Electric Literature of C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: cis-13-Docosenamide《Non-targeted analysis by DLLME-GC-MS for the monitoring of pollutants in the Mar Menor lagoon》 was published in 2022. The authors were Penalver, Rosa;Ortiz, Alberto;Arroyo-Manzanares, Natalia;Campillo, Natalia;Lopez-Garcia, Ignacio;Vinas, Pilar, and the article was included in《Chemosphere》. The author mentioned the following in the article:

Non-targeted anal. for the monitoring of organic pollutants resulting from agricultural and industrial practices, plastics and pharmaceutical products of seawater from the Mar Menor lagoon (SE Spain) is proposed using dispersive liquid-liquid microextraction (DLLME) and gas chromatog.-mass spectrometry (GC-MS). Initially, a home-made MS database including 118 environmental organic pollutants, whose presence in different ecosystems has already been reported, was created. The anal. method was applied for the anal. of 42 samples and a total of 18 pollutants were detected and identified. Samples were obtained from different sites around the Mar Menor in three sampling campaigns, enabling the assessment of impact of rain on the input of the detected chems. and their distribution. In addition, this methodol. was validated using a standard mixture containing 54 of the environmental pollutants included in the database, allowing the quantification of the 9 of the identified compounds (di-Bu phthalate, diisobutyl phthalate, di-Et phthalate, bis(2-ethylhexyl) phthalate, anthracene, 2-methylnaphthalene, hexachlorocyclopentadiene, bis(2-ethylhexyl) adipate and oleamide) with concentration between 3 and 271μg L-1. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Name: cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cun, Meng;Mao, Jincheng;Sun, HaiLin;Wei, Guo;Tang, Feng;Zhang, Wenlong;Tian, Jizhen;Yang, Xiaojiang;Lin, Chong;Huang, ZiGao published 《Development of a novel temperature-resistant and salt-resistant double-cationic surfactant with “super thick hydration layer” for clean fracturing fluid》. The research results were published in《Colloids and Surfaces, A: Physicochemical and Engineering Aspects》 in 2021.Computed Properties of C22H43NO The article conveys some information:

In recent years, cationic surfactants have received extensive attention in cleaning fracturing fluid thickeners due to various unique properties. At the same time, the development of temperature-resistant and salt-resistant clean fracturing fluid is the key to deep well oil and gas resource development. In this study, the rigid-soft combined strategy is adopted for mol. structure designs. N,N-dimethylcyclohexylamine and epichlorohydrin are used as the initial reactants; after the ring-opening reaction occurs, they are quaternized with erucamide Pr di-Me ammonium to synthesize a novel double-cation viscoelastic surfactant, SY-JS. With double-cationic charges on the head group, water mols. are selectively adsorbed around the cation lattice to increase the hydration layer, and thus, salt tolerance is improved. Cyclohexane with a rigid structure improves temperature resistance. The ultra-long unsaturated hydrophobic tail imparts excellent heat tolerance and dissoly. to the designed viscoelastic surfactant. The clean fracturing fluid prepared by 3 wt% SY-JS with 130,000 ppm NaCl or KCl performs well under a shear rate of 170 s^-1 at 140°C, and the apparent viscosity remains above 30 mPa s^-1 after 120 min.. Addnl., the results show that single-tail surfactants exhibit excellent performance at approx. 140°C. Afterward, the brine produced from Rumaila and Jiyuan oil fields is used to prepare brine-based clean fracturing fluids, and evaluations, including proppant suspension, gel breaking, and permeability damage, were conducted. The results show that the brine-based clean fracturing fluid completely meets the requirements of hydraulic fracturing industrial application. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Computed Properties of C22H43NO

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Champion, Cody J.;Xu, Jiannong published 《Redox state affects fecundity and insecticide susceptibility in Anopheles gambiae》 in 2018. The article was appeared in 《Scientific Reports》. They have made some progress in their research.Formula: C6H7N3O The article mentions the following:

Redox reactions play a central role in the metabolism of an organism. It is vital to maintain redox homeostasis in response to the fluctuation of redox shift in various biol. contexts. NADPH-dependent reducing capacity is one of the key factors contributing to the redox homeostasis. To understand the redox capacity and its impact on mosquito fecundity and susceptibility to insecticides in Anopheles gambiae, we examined the dynamics of elevated oxidative state via induction by paraquat (PQ) and the inhibition of NADPH regeneration by 6-aminonicotinamide (6AN). In naive conditions, inherent oxidative capacity varies between individuals, as measured by GSSG/GSH ratio. The high GSSG/GSH ratio was neg. correlated with fecundity. Both PQ and 6AN feeding increased GSSG/GSH ratio and elevated protein carbonylation, a marker of oxidative damage. Both pro-oxidants lowered egg production Co-feeding the pro-oxidants with antioxidant lycopene attenuated the adverse effects on fecundity, implying that oxidative stress was the cause of this phenotype. Pre-feeding with 6AN increased insecticide susceptibility in DDT resistant mosquitoes. These results indicate that oxidative state is delicate in mosquitoes, manipulation of NADPH pool may adversely affect fecundity and insecticide detoxification capacity. This knowledge can be exploited to develop novel vector control strategies targeting fecundity and insecticide resistance. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Formula: C6H7N3O induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Eysseric, Emmanuel;Gagnon, Christian;Segura, Pedro A. published 《Identifying congeners and transformation products of organic contaminants within complex chemical mixtures in impacted surface waters with a top-down non-targeted screening workflow》 in 2022. The article was appeared in 《Science of the Total Environment》. They have made some progress in their research.Product Details of 112-84-5 The article mentions the following:

Over 350,000 compounds are registered for production and use including a high number of congeners found in complex chem. mixtures (CCMs). With such a high number of chems. being released in the environment and degraded into transformation products (TPs), the challenge of identifying contaminants by non-targeted screening (NTS) is massive. “Bottom-up” studies, where compounds are subjected to conditions simulating environmental degradation to identify new TPs, are time consuming and cannot be relied upon to study the TPs of hundreds of thousands of compounds Therefore, the development of “top-down” workflows, where the structural elucidation of unknown compounds is carried directly on the sample, is of interest. In this study, a top-down NTS workflow was developed using mol. networking and clustering (MNC). A total of 438 compounds were identified including 176 congeners of consumer product additives and 106 TPs. Reference standards were used to confirm the identification of 53 contaminants among them lesser-known pharmaceuticals (aliskiren, sitagliptin) and consumer product additives (lauramidopropyl betaine, 2,2,4-trimethyl-1,2-dihydroquinoline). The MNC tools allowed to group similar TPs and congeners together. As such, several previously unknown TPs of pesticides (metolachlor) and pharmaceuticals (gliclazide, irbesartan) were identified as tentative candidates or probable structures. Moreover, some congeners that had no entry on global repositories (PubChem, ChemSpider) were identified as probable structures. The workflow worked efficiently with oligomers containing ethylene oxide moieties, and with TPs structurally related to their parent compounds The top-down approach shown in this study addresses several issues with the identification of congeners of industrial compounds from CCMs. Furthermore, it allows elucidating the structure of TPs directly from samples without relying on bottom-up studies under conditions discussed herein. The top-down workflow and the MNC tools show great potential for data mining and retrospective anal. of previous NTS studies. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of cis-13-DocosenamideIn 2021, Liu, Zhengqi;Zhang, Yujiao;Ai, Chunqing;Wen, Chengrong;Dong, Xiuping;Sun, Xiaona;Cao, Cui;Zhang, Xueqian;Zhu, Beiwei;Song, Shuang published 《Gut microbiota response to sulfated sea cucumber polysaccharides in a differential manner using an in vitro fermentation model》. 《Food Research International》published the findings. The article contains the following contents:

Sea cucumber Stichopus japonicus has been consumed as high-valued seafood in Asian, and its sulfated polysaccharide (SCSPsj) has been inferred to benefit the host health via modulating gut microbiota composition The present study compared the responses of gut microbiota communities from different donors to SCSPsj, and the key bacteria were identified by 16S rRNA gene sequencing anal. and in vitro fermentation with specific bacteria. Gut microbiota communities from 6 donors (A ∼ F) utilized the polysaccharides to different degrees in vitro fermentation Further comparison of Samples A and C demonstrated that Sample C with the relatively strong SCSPsj utilization capability possessed more Parabacteroides while Sample A contained more Bacteroides. Further in vitro fermentation of SCSPsj with 10 Parabacteroides and Bacteroides species suggests that Parabacteroides distasonis, enriched in Sample C, plays a critical role in the utilization of the polysaccharides. Moreover, short chain fatty acids and the metabolite profiles of Samples A and C were also compared, and the results showed that more beneficial metabolites were accumulated by the microbiota community consuming more sulfated sea cucumber polysaccharides. Our findings revealed that certain key members of gut microbiota, such as Parabacteroides distasonis, are critical for SCSPsj utilization in gut so as to influence the benefits of the polysaccharide supplement for host. Thus, to obtain better functional outcome for sulfated sea cucumber polysaccharides and sea cucumber, more attention needs to be paid to the effects of inter-individual differences in microbiota community structure. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Quality Control of cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 89-73-6《Accurate calculation of equilibrium constants using potentiometric titrations》 was published in 2022. The authors were Phansi, Piyawan;Ferreira, Sergio L. C.;Cerda, Victor, and the article was included in《TrAC, Trends in Analytical Chemistry》. The author mentioned the following in the article:

The aim of this work is to revise some programs, which are used to obtain accurate equilibrium constants using several chained programs. For this purpose, the AutoAnal. software is very useful to perform the exptl. work, including potentiometric titrations The POTENtit program allows detecting some problems in the data obtained with AutoAnal. along the exptl. work, like the presence of metals in the sample and the carbonation of the titrant. This program also allows obtaining the standard potential of the working electrode, and the ionic product of the solvent under the used exptl. ionic strength. Finally the MINIPOT program allows refining the results obtained, both for the calibration of the electrodes (E0, jH, JOH, pKs, and g) and for the constants equilibrium (HqLp or MqLp). These three mentioned programs have been updated in order to run under the Windows 10 environment.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Product Details of 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics