Month: September 2022

Synthetic Route of C22H43NOIn 2021, McPartlin, Michael W.;Italiano, Brandon R.;Tiano, Thomas M.;Pilkenton, Sarah J.;Lawton, Timothy J. published 《An approach to identifying fibers and evolved compounds from flame resistant fabrics》. 《Journal of Analytical and Applied Pyrolysis》published the findings. The article contains the following contents:

Flame resistant (FR) fabrics have use in civilian, military, and industrial applications. This work describes the development of a methodol. aimed at identifying the fiber composition of blended fabrics of unknown composition Here, FR fabrics used in military uniforms, are studied using a combination of XPS, isothermal thermogravimetric anal. (TGA) and pyrolysis gas chromatog./mass spectrometry (Py-GC-MS). Elemental anal. of the fabrics using XPS yielded a preliminary determination of the composition of the polymer(s) and aided in the identification of FR additives. TGA and Py-GC-MS experiments were used for subsequent compound identification. In TGA the temperature of mass loss events was compared to reference materials, and in Py-GC-MS the pyrolysis products of the blended FR fabrics were compared to those from a series of potential parent fibers. It was possible to discern the composition of the parent fibers and the type of FR treatment added to fabrics because the thermal decomposition chem. did not significantly change by blending the fibers to make fabrics. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Synthetic Route of C22H43NO

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 112-84-5In 2022, Navratilova, Klara;Hurkova, Kamila;Hrbek, Vojtech;Uttl, Leos;Tomaniova, Monika;Valli, Enrico;Hajslova, Jana published 《Metabolic fingerprinting strategy: Investigation of markers for the detection of extra virgin olive oil adulteration with soft-deodorized olive oils》. 《Food Control》published the findings. The article contains the following contents:

As extra virgin olive oil (EVOO) is a high value commodity, it might be subject of various fraudulent practices. This study is focused on a challenging authentication issue, addition of lower grade, soft-deodorized olive oil to EVOO. In the first step, sample sets of authentic EVOOs, soft-deodorized oils and their admixtures were extracted by aqueous methanol; obtained polar fractions were then analyzed by ultra-high performance liquid chromatog. coupled to hybrid quadrupole time-of-flight high-resolution tandem mass spectrometry (UHPLC-QTOF-HRMS/MS). Subsequent chemometric evaluation of metabolic fingerprints enabled suggestion of several ions that might be characteristic for deodorized oils; most of tentatively identified compounds were oxidized fatty acid derivatives In the second phase, the marker ions were employed for target anal. by ultra-high performance liquid chromatog. coupled to triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS) what enabled achieving lower the detection limits. Two compounds were selected as the best markers for detection of soft-deodorized olive oil addition, tentatively identified as Me ester of hydroxy octadecenoic acid and ester derivative of oleic acid. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.HPLC of Formula: 112-84-5 It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Viererbl, L.;Kolros, A.;Vin, M.;Klupak, V. published 《Detection of neutrons emitted from reactor primary circuit water by discontinuing flow method》 in 2021. The article was appeared in 《Journal of Nuclear Engineering and Radiation Science》. They have made some progress in their research.Reference of cis-13-Docosenamide The article mentions the following:

Online activity measurement of fission products in a primary circuit water is often used for a fuel failure detection in research and power nuclear reactors. When gamma spectrometry is used for the activity measurement, high signal from 16N radionuclide and other activation products make the detection of fission products difficult. The detection of delayed neutrons emitted from several fission products is also used; however, if the detector is placed near the outlet coolant pipe, the signal from the delayed neutrons cannot be distinguished from the neutrons emitted due to ¹⁷N decay and deuterium photofission, with exception of a reactor scram condition. In this paper, a method of discontinuing the flow of primary circuit water is described. This method is based on the water flowing through a bypass on the outlet pipe to the sampling container and the flow is periodically temporarily interrupted, e.g., using 200s + 200 s cycles. Neutrons located in the vicinity of the sampling container are continuously detected with a measuring sampling time of less than 2s. The signal part, corresponding to the delayed neutrons, is evaluated by the signal decay analyzing during the flow interruption. The main sources of delayed neutrons suitable for this method are ¹³⁷I, ⁸⁷Br, and ⁸⁸Br radionuclides with half-lives of 24.5 s, 55.7 s, and 16.5 s, resp. The method was theor. analyzed and exptl. verified in the LVR-15 research reactor.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Reference of cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C6H7N3OIn 2015, Gladysz, Rafaela;Adriaenssens, Yves;De Winter, Hans;Joossens, Jurgen;Lambeir, Anne-Marie;Augustyns, Koen;Van der Veken, Pieter published 《Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:

Urokinase plasminogen activator (uPA) is a biomarker and therapeutic target for several cancer types. Its inhibition is regarded as a promising, noncytotoxic approach in cancer therapy by blocking growth and/or metastasis of solid tumors. Earlier, the authors reported the modified substrate activity screening (MSAS) approach and applied it for the identification of fragments with affinity for uPA’s S1 pocket. Here, these fragments are transformed into a novel class of uPA inhibitors with an imidazo[1,2-a]pyridine scaffold. The SAR for uPA inhibition around this scaffold is explored, and the best compounds in the series have nanomolar uPA affinity and selectivity with respect to the related trypsin-like serine proteases (thrombin, tPA, FXa, plasmin, plasma kallikrein, trypsin, FVIIa). Finally, the approach followed for translating fragments into small mols. with a decorated scaffold architecture is conceptually straightforward and can be expected to be broadly applicable in fragment-based drug design. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Synthetic Route of C6H7N3O induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sang, Dayong;Tian, Juan;Tu, Xiaodong;He, Zhoujun;Yao, Ming published 《Cleavage of Catechol Monoalkyl Ethers by Aluminum Triiodide-Dimethyl Sulfoxide》. The research results were published in《Synthesis》 in 2019.Application of 2444-46-4 The article conveys some information:

Using eugenol and vanillin as model substrates, a practical method is developed for the cleavage o-hydroxyphenyl alkyl ethers. Aluminum oxide iodide (O=AlI), generated in situ from aluminum triiodide and DMSO, is the reactive ether cleaving species. The method is applicable to catechol monoalkyl ethers as well as normal Ph alkyl ethers for the removal of Me, Et, iso-Pr, and benzyl groups. A variety of functional groups such as alkenyl, allyl, amide, cyano, formyl, keto, nitro, and halogen are well tolerated under the optimum conditions. Partial hydrodebromination was observed during the demethylation of 4-bromoguaiacol, and was resolved using excess DMSO as an acid scavenger. This convenient and efficient procedure would be a practical tool for the preparation of catechols. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Application of 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 112-84-5In 2022, Fu, Yong-Ping;Yuan, Huan;Xu, Yan;Liu, Ru-Ming;Luo, Yi;Xiao, Jian-Hui published 《Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings》. 《Phytomedicine》published the findings. The article contains the following contents:

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by high levels of proinflammatory cytokines and epithelial barrier dysfunction. The root of Ligularia fischeri (Ledeb.) Turcz. is a traditional Chinese medicinal herb with diverse therapeutic properties, which has been successfully used to treat inflammation-related diseases. However, little is known about its effect and mechanism against UC. To investigate the efficacy and mechanism of L. fischeri root extracts against UC. L. fischeri root samples were prepared using the alc. extraction method and liquid-liquid extraction method. A dextran sodium sulfate-induced UC mouse model and a lipopolysaccharide (LPS)-induced inflammatory cell model were employed in the present study. Cell apoptosis was detected by TUNEL staining, and an ELISA was used to quantify the abundance of inflammatory factors in tissues. Hematoxylin and eosin staining and Masson staining were employed to analyze drug toxicity to the liver and kidney. A myeloperoxidase (MPO) assay kit was used to detect neutrophil infiltration in colon tissues. RT-qPCR was then employed to quantify the transcriptional levels of proinflammatory and apoptotic-related genes, while tight junction and apoptosis-related proteins were quantified via western blotting. Gas Chromatog./Mass Spectrometry anal. was then performed to identify the natural compounds in L. fischeri root extracts The water decoction extract, methanol extract, and especially the chloroform extract (CE) exerted potent therapeutic effects in UC mice. Similar to the pos. control group (5-aminosalicylic acid), oral administration of CE (30, 60, and 90 mg/kg/d) elicited distinct therapeutic effects on UC mice in the medium- and high-dose groups. CE decreased disease activity index, histopathol. score, and MPO level significantly, and effectively retained the colon length. Furthermore, CE significantly reduced the levels of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α and enhanced the expression of tight junction proteins, such as zonula occludens (ZO)-1, ZO-2, claudin-1, and occludin, as well as the transcriptional levels of mucins, such as MUC-1 and MUC-2, in UC mice. Notably, CE prevented apoptosis of colonic epithelial cells by up-regulating Bcl-2 and down-regulating Bax. Also, CE inhibited the secretion of pro-inflammatory cytokines and apoptosis in LPS-induced RAW264.7 macrophages via the activation of Bcl-2/Bax signals.Collectively, L. fischeri root extracts, especially CE, have obvious therapeutic effects against UC. CE reduces inflammation and protects the intestinal epithelial cells and intestinal epithelial barrier via activation of the Bcl-2/Bax signaling pathway, and may be a promising therapeutic agent for UC treatment. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Yuanyuan;Jin, Tianlin;Wang, Xue;Liang, Dacheng published 《Phytosterol alterations responding to ROS inhibitors by GC-MS in Arabidopsis》. The research results were published in《Pakistan Journal of Botany》 in 2022.Computed Properties of C7H7NO3 The article conveys some information:

Phytosterols, essential components of cellular membrane integrity, play an important role in plant growth, development, and responses to various types of stressors. Emerging studies have proposed that phytosterols are a result of adaptation to the aerobic environment during evolution. We reasoned that phytosterols could dramatically respond to changes in external reactive oxygen species (ROS) levels. The levels of five phytosterols were measured by gas chromatog.-mass spectrometry (GC-MS) after Arabidopsis plants were treated with the ROS-altering drugs 2′-3′-dideoxycytidine (DDC), H2O2, Catalase (CAT), diphenyleneiodonium (DPI), and salicylhydroxamic acid (SHAM) and auxin transport inhibitors 2,3,5-triiodobenzoic acid (TIBA) and 1-N-naphthylphthalamic acid (NPA). We found that all redox-altering agents can dramatically reduce sterol levels, whereas CAT and NPA can partly increase them. Our results establish a link between redox balance and sterol level alteration. The experimental procedure involved many compounds, such as N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Computed Properties of C7H7NO3It inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 329-89-5In 2013, Sugita, Kazunari;Ikenouchi-Sugita, Atsuko;Nakayama, Yasuko;Yoshioka, Haruna;Nomura, Takashi;Sakabe, Jun-Ichi;Nakahigashi, Kyoko;Kuroda, Etsushi;Uematsu, Satoshi;Nakamura, Jun;Akira, Shizuo;Nakamura, Motonobu;Narumiya, Shuh;Miyachi, Yoshiki;Tokura, Yoshiki;Kabashima, Kenji published 《Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.》. 《Scientific reports》published the findings. The article contains the following contents:

Pellagra is a photosensitivity syndrome characterized by three “D’s”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE2 production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation. And 6-Aminonicotinamide (cas: 329-89-5) was used in the research process.

6-Aminonicotinamide (cas:329-89-5)Product Details of 329-89-5 is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Cui;He, Qian;Zeng, Linlin;Shen, Ling;Luo, Qiaomei;Zhang, Wentao;Zhou, Xia;Wan, Jun published 《Digestion-Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus》 in 2021. The article was appeared in 《Chemistry & Biodiversity》. They have made some progress in their research.Computed Properties of C22H43NO The article mentions the following:

Emerging evidence suggests that a high-fat diet (HFD) can influence endoplasmic reticulum (ER) stress and gut microbiota. Crataegi Fructus is a traditional Chinese herb widely used in formulas for dyspepsia, with Dashanzha Pill composed of raw Crataegi Fructus (DR) being a representative drug. Processing products of Crataegi Fructus, however, have a stronger pro-digestive effect, and we hypothesized that Dashanzha Pill composed of charred Crataegi Fructus (DC) is more effective. We found that the contents of glucose 1-phosphate and luteolin in DR and DC were substantially different via ultra-high performance liquid chromatog.-hybrid quadrupole-Orbitrap high-resolution mass spectrometry. DC outperformed DR in improving histopathol. changes, increasing gastrin and motilin, and decreasing vasoactive intestinal peptides in rats with HFD induced dyspepsia. Fecal microbiota anal. revealed that DC could restore the disturbed intestinal microbiota composition, including that of Bacteroides, Akkermansia, and Intestinimonas to normal levels. Furthermore, DC significantly reduced the mRNA and protein levels of glucose-regulated protein 78, protein kinase R-like ER kinase, and eukaryotic initiation factor 2α. Taken together, DC outperformed DR in relieving dyspepsia by regulating gut microbiota and alleviating ER stress.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Computed Properties of C22H43NO

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 2444-46-4In 2019, Calvo, Roxan;Zhang, Kun;Passera, Alessandro;Katayev, Dmitry published 《Facile access to nitroarenes and nitroheteroarenes using N-nitrosaccharin》. 《Nature Communications》published the findings. The article contains the following contents:

Nitroaroms. and nitroheteroaroms. serve as key building blocks and intermediates in synthesis, and form the core scaffold of a vast number of materials, dyes, explosives, agrochems. and pharmaceuticals. However, their synthesis relies on harsh methodologies involving excess mineral acids, which present a number of critical drawbacks in terms of functional group compatibility and environmental impact. Modern, alternative strategies still suffer from significant limitations in terms of practicality, and a general protocol amenable to the direct C-H functionalization of a broad range of aromatics has remained elusive. Herein, author introduces a bench-stable, inexpensive, easy to synthesize and recyclable nitrating reagent based on saccharin. This reagent acts as a controllable source of the nitronium ion, allowing mild and practical nitration of both arenes and heteroarenes displaying an exceptional functional group tolerance. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.SDS of cas: 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics