Month: September 2022

SDS of cas: 2444-46-4《Voltammetric determination of capsaicin using CeO₂-surfactant/SWNT-modified electrode》 was published in 2020. The authors were Ziyatdinova, Guzel;Ziganshina, Endzhe;Shamsevalieva, Aliya;Budnikov, Herman, and the article was included in《Arabian Journal of Chemistry》. The author mentioned the following in the article:

Glassy carbon electrodes (GCE) modified with carboxylated single-walled carbon nanotubes (SWNT-COOH) and CeO₂-surfactants dispersions are developed for the capsaicin quantification. The effect of cationic cetylpyridinium bromide (CPB), anionic sodium dodecylsulfate (SDS) and nonionic Triton X100 as co-modifiers are tested. CeO₂-CPB/SWNT-COOH/GCE provides 2.8- and 1.9-fold increase of capsaicin oxidation currents in comparison to bare GCE and SWNT-COOH/GCE, resp., confirming the synergetic effect of the modifiers. SEM (SEM) data confirm successful immobilization of the nanomaterials on the electrode surface leading to the significant changes in its morphol. The parameters of capsaicin electrooxidation are found. Differential pulse mode is applied for the capsaicin determination The pulse parameters are optimized. The linear dynamic ranges of 0.10-7.5 and 7.5-500μM of capsaicin with the limits of detection and quantification of 28 and 92 nM resp. confirm the high sensitivity of the method developed. The selectivity of the electrode toward capsaicinoids is proved. The method was applied for the total capsaicinoids quantification in real samples (red hot pepper spices and tinctures of Capsicum annuum L.). A good agreement with the UV-spectroscopic data is obtained.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.SDS of cas: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vegas-Suarez, Sergio;Aristieta, Asier;Requejo, Catalina;Bengoetxea, Harkaitz;Lafuente, Jose Vicente;Miguelez, Cristina;Ugedo, Luisa published 《The effect of 5-HT_1A receptor agonists on the entopeduncular nucleus is modified in 6-hydroxydopamine-lesioned rats》. The research results were published in《British Journal of Pharmacology》 in 2021.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

L-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT1A receptors. Since the internal segment of the globus pallidus, homologous to the entopeduncular nucleus in rodents, seems to be involved in the etiopathol. of L-DOPA-induced dyskinesia, we investigated whether the entopeduncular nucleus is modulated by the 5-HT_1A receptor partial and full agonists, buspirone, and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) in control and 6-hydroxydopamine (6-OHDA)-lesioned rats with or without long-term L-DOPA treatment. Extracellular single-unit electrocorticogram and local field potential recordings under anesthesia, immunostaining assays and optogenetic manipulation coupled to electrophysiol. recordings were performed. Systemic buspirone reduced the entopeduncular nucleus firing rate in the sham animals and burst activity in the 6-OHDA-lesioned rats (with or without L-DOPA treatment), while local administration reduced entopeduncular nucleus activity in all the groups, regardless of DA integrity. Systemic 8-OH-DPAT also induced inhibitory effects only in the sham animals. Effects triggered by buspirone and 8-OH-DPAT were reversed by the 5-HT_1A receptor antagonist, WAY-100635. Neither buspirone nor 8-OH-DPAT modified the low-frequency oscillatory activity in the entopeduncular nucleus or its synchronization with the motor cortex. Buspirone did not alter the response induced by subthalamic nucleus opto-stimulation in the entopeduncular nucleus. Systemic 5-HT_1A receptor activation elicits different effects on the electrophysiol. properties of the entopeduncular nucleus depending on the integrity of the nigrostriatal pathway and it does not alter the relationship between subthalamic nucleus and entopeduncular nucleus neuron activity. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Recommanded Product: N,2-Dihydroxybenzamide The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Xiaoyi;Xu, Zhijie;Zhu, Zhijian;Chen, Anqi;Fu, Guanghou;Wang, Yimin;Pan, Hao;Jin, Baiye published 《Modulation of G6PD affects bladder cancer via ROS accumulation and the AKT pathway in vitro》. The research results were published in《International Journal of Oncology》 in 2018.Reference of 6-Aminonicotinamide The article conveys some information:

Glucose-6-phosphate dehydrogenase (G6PD) is a rate-limiting enzyme of the pentose phosphate pathway. Multiple studies have previously revealed that elevated G6PD levels promote cancer progression in numerous tumor types; however, the underlying mechanism remains unclear. In the present study, it was demonstrated that high G6PD expression is a poor prognostic factor in bladder cancer, and the levels of G6PD expression increase with increasing tumor stage. Patients with bladder cancer with high G6PD expression had worse survival rates compared with those with lower G6PD expression in resected tumors. In vitro experiments revealed that knockdown of G6PD suppressed cell viability and growth in Cell Counting Kit-8 and colony formation assays, and increased apoptosis in bladder cancer cell lines compared with normal cells. Further experiments indicated that the weakening of the survival ability in G6PD-knockdown bladder cancer cells may be explained by intracellular reactive oxygen species accumulation and protein kinase B pathway suppression. Furthermore, it was addnl. revealed that 6-aminonicotinamide (6-AN), a competitive G6PD inhibitor, may be a potential therapy for bladder cancer, particularly in cases with high G6PD expression, and that the combination of cisplatin and 6-AN may optimize the clin. dose or minimize the side effects of cisplatin. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Reference of 6-Aminonicotinamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C17H27NO3《Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking》 was published in 2022. The authors were He, Yue;Zhang, Xiaoyin;Li, Ming;Zheng, Nan;Zhao, Shengguo;Wang, Jiaqi, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

Inhibition of ruminal bacterial urease activity could slow down the decomposition of urea to ammonia, which would lead to a decrease in urea synthesis in the liver and urea-N emission in the urine. In order to find a rumen bacterial urease specific inhibitor that is environmentally friendly, we used the homol. model of rumen bacterial urease as the target to screen natural compounds from plants by mol. docking. The screening results showed that coptisine had the most potential to inhibit the activity of rumen bacterial urease with an IC50 of 2.45μM, which was superior to the traditional inhibitor acetohydroxamic acid. The enzyme kinetics results indicated coptisine was mixed type inhibitor of rumen bacterial urease with a Ki value of 0.68μM. Coptisine significantly decreased the release of NH3 and decomposition of urea and improved microbial fermentation in a rumen fermentation system in vitro. Thiol-containing compounds or boric acid significantly decreased the inhibitory capacity of coptisine toward rumen bacterial urease, which indicated that coptisine could interact with both the urease active center Ni and amino acid residues possessing sulfhydryl groups in the flap area. The mol. docking results showed that coptisine acted as the metal acceptor for one nickel ion in the active site, and formed hydrogen bonds with the amino acid residues His320 and His362, which were located in the active site and flap region, resp. These findings emphasized the potential role of coptisine in reducing nitrogen emissions that originate from ruminants by regulating rumen bacterial urease activity. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.COA of Formula: C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guo, Zhen;Li, Xiu-qin;Gao, Fang-yuan;Zhang, Qing-he;Li, Hong-mei published 《Determination of capsaicinoids in edible oil by liquid chromatography-isotope dilution mass spectrometry》. The research results were published in《Huaxue Shiji》 in 2016.Name: N-Vanillylnonanamide The article conveys some information:

A method was developed on determination of capsaicinoids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin and n-vanillvlnonanamide) in edible oil by liquid chromatog.-isotope dilution mass spectrometry (LC-IDMS). The sample was firstly extracted with sodium hydroxide solution, and then the extract was cleaned-up by auto solid phase extraction (SPE) before the LC-IDMS anal. The limit of detection (LOD, S/N>3) for capsaicinoids was 0.015 μg/kg, and the recoveries of the 4 kinds of capsaicinoids in edible oil samples were 96.2%-105% with the RSDs ranging 0.5%-3.8% (n = 6). Edible oils and illegal edible oils were both analyzed using this method, and significant differences were observed The results showed that there were no capsaicinoids in most kinds of edible oils. Peanut oil contained little capsaicinoids ranging 0-1.8 μg/kg which might come from peanut. The content of capsaicinoids was above 600 μg/kg in most illegal cooking oils. This method can be used as one of identification methods on illegal cooking oil. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Name: N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: cis-13-DocosenamideIn 2021, Zuo, Lizeng;Chen, Yanan;Chen, Guiji;Lu, Xianbo;Zhao, Pengwei published 《Effects of pigments on laser marking properties of polypropylene-based composites》. 《Gongcheng Suliao Yingyong》published the findings. The article contains the following contents:

In order to investigate the influence of pigments on laser marking properties of polypropylene (PP) based composites, composite boards were prepared by utilizing PP as the matrix, mica, antioxidants as the additive ingredients, phthalo blue, phthalocyanine green, titania white and carbon black as the pigments via melting extrusion and injection molding. Composite marking boards were prepared by laser marking, |ΔL|andΔE value before and after laser marking were evaluated by colorimeter. The effects of pigments including phthalo blue, phthalocyanine green, titania white and carbon black on laser marking properties of PP-based composites were estimated The results show that phthalo blue, phthalocyanine green and titanium white have two sides on laser marking, i.e. a small amount of additive can decrease the effect of laser marking, while when the content is increased, the effect can be weakened by increasing the difference between their own color and the sample. On the other hand, the higher carbon black content, the weaker the marking effect. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Recommanded Product: cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xiao, Wen-jing;Ma, Ting;Ge, Chun;Xia, Wen-juan;Mao, Yong;Sun, Run-bin;Yu, Xiao-yi;Aa, Ji-ye;Wang, Guang-ji published 《Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells》. The research results were published in《Acta Pharmacologica Sinica》 in 2015.SDS of cas: 329-89-5 The article conveys some information:

Aim: The pentose phosphate pathway (PPP) is involved in the activity of glucose-6-phosphate dehydrogenase (G6PD) and generation of NADPH, which plays a key role in drug metabolism The aim of this study was to investigate the effects of modulation of the PPP on drug metabolism capacity in vitro. Methods: A pair of hepatic cell lines, ie, the cancerous HepG2 cells and normal L02 cells, was used. The expression of CYP450 enzymes, p53 and G6PD in the cells were analyzed. The metabolism of testosterone (TEST, 10 μmol/L) and dextromethorphan (DEM, 1 μmol/L), the two typical substrates for CYP3A4 and CYP2D6, in the cells was examined in the presence of different agents. Results: Both the expression and metabolic activities of CYP3A4 and CYP2D6 were considerably higher in HepG2 cells than in L02 cells. The metabolism of TEST and DEM in HepG2 cells was dose-dependently inhibited by the specific CYP3A4 inhibitor ketoconazole and CYP2D6 inhibitor quinidine. Addition of the p53 inhibitor cyclic PFT-α (5, 25 μmol/L) in HepG2 cells dose-dependently enhanced the metabolism of DEM and TEST, whereas addition of the p53 activator NSC 66811 (3, 10, 25 μmol/L) dose-dependently inhibited the metabolism Furthermore, addition of the G6PD inhibitor 6-aminonicotinamide (5, 15 μmol/L) in HepG2 cells dose-dependently inhibited the metabolism of DEM and TEST, whereas addition of the PPP activity stimulator menadione (1, 5, 15 μmol/L) dose-dependently enhanced the metabolism Conclusion: Modulation of p53 and the PPP alters the metabolism of DEM and TEST, suggesting that the metabolic flux pattern of PPP may be closely involved in drug metabolism and the individual variance. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)SDS of cas: 329-89-5 is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Qian;Yao, Li;Qin, Panzhu;Xu, Jianguo;Sun, Xun;Yao, Bangben;Ren, Fei;Chen, Wei published 《Time-resolved fluorescent lateral flow strip for easy and rapid quality control of edible oil》 in 2021. The article was appeared in 《Food Chemistry》. They have made some progress in their research.Name: N-Vanillylnonanamide The article mentions the following:

Gutter oil is strictly prohibited from being reprocessed back to the catering and food industry. Extensive attention has been paid to rapid screening of gutter oil to guarantee the safety of edible oil. Capsaicin, a special component of condiments, has been adopted as the marker of gutter oil. The time-resolved fluorescent microspheres are utilized for labeling of antibody to capsaicin, which are further applied for the construction of fluorescent lateral-flow-strip (LFS). By simple extraction of capsaicin with ethanol (or liquor) from the edible oil, the capsaicin can be rapid determined with the fluorescent LFS in less than 10 min. As low as 20 ng/mL capsaicin can be visually judged and 2.3 ng/mL is achieved as the detection limit by ImageJ anal. The illegal gutter oil is also well screened with this time-resolved LFS. This method can be a useful candidate for routine quality monitoring of edible oil and a powerful tool for self-inspection at home.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Name: N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: N,2-DihydroxybenzamideIn 2020, Li, Yu-Ting;Liu, Mei-Jun;Li, Ying;Liu, Peng;Zhao, Shi-Jie;Gao, Hui-Yuan;Zhang, Zi-Shan published 《Photoprotection by mitochondrial alternative pathway is enhanced at heat but disabled at chilling》. 《Plant Journal》published the findings. The article contains the following contents:

SUMMARY : The mitochondrial alternative pathway (AP) represents an important photoprotective mechanism for the chloroplast, but the temperature sensitivity of its photoprotective role is unknown. In this study, using the aox1a Arabidopsis mutant, the photoprotective role of the AP was verified under various temperatures, and the mechanism underlying the temperature sensitivity of the AP’s photoprotective role was clarified. It was observed that the photoprotective role of the AP increased with rising temperature but was absent at low temperature The photoprotective role of the AP was severely reduced under non-photorespiratory conditions. Disturbance of the AP inhibited the conversion of glycine to serine in mitochondria, which may restrain upstream photorespiratory metabolism and aggravate photoinhibition. With rising temperatures, photorespiration accelerated and the restraint of photorespiration caused by disturbance of the AP also increased, determining the temperature sensitivity of the AP’s photoprotective role. We also verified that not only the AP but also the cytochrome pathway in mitochondria contributes to photoprotection by maintaining photorespiration.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Recommanded Product: N,2-Dihydroxybenzamide The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Borusiewicz, Rafal;Martyna, Agnieszka;Zadora, Grzegorz;Zahrebelna, Anastasiia published 《Differentiation of oleoresin capsicum sprays based on their capsaicinoid profiles》 in 2021. The article was appeared in 《Forensic Science International》. They have made some progress in their research.Electric Literature of C17H27NO3 The article mentions the following:

Oleoresin capsicum (OC) sprays, often referred to as pepper sprays, contain a solution of active compounds, exerting an irritating effect on the human body. The active component of OC sprays are capsaicinoids, obtained by extraction from peppers. The profiles (quant. relations) of natural capsaicinoids depend on the plant material, they were extracted from. Pepper spray is a non-lethal weapon that should only be used for self-defense but is often used by criminals to attack and incapacitate victims. Evidence related to these types of incidents, such as containers, clothes of victims or suspects, as well as traces of substances found at the scene, are submitted to the forensic laboratory The purpose of the anal. is to identify the ingredients of the preparation (especially active components) and compare the traces found on objects from the victim or the scene of the incident with the preparation from the can or traces found on objects related to the suspect. The study aimed to investigate the possibility of differentiating OC gases based on capsaicinoid profiles recorded in GC-MS analyses. Sixty-four gases from 12 different manufacturers were purchased and tested. The likelihood ratio (LR) approach was applied to the data expressing the relative capsaicinoids contents computed by integrating GC-MS signals. Two hypotheses were assumed that stated either common or different origins of the samples. Several LR models have been developed, and their performance has been controlled by the number of false positives and false negatives as well as empirical cross entropy. The research results showed that differentiation was very successful, with more than 90% of correct responses. The results obtained show that OC sprays may be distinguished, even if they were produced by the same producer presumably if produced using different batches of pepper extract To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Electric Literature of C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics