Month: September 2022

Name: cis-13-DocosenamideIn 2021, Wang, Kanghui;Tian, Jingyuan;Li, Yueshan;Liu, Mengshi;Chao, Yingxin;Cai, Yi;Zheng, Guodong;Fang, Yi published 《Identification of Components in Citri Sarcodactylis Fructus from Different Origins via UPLC-Q-Exactive Orbitrap/MS》. 《ACS Omega》published the findings. The article contains the following contents:

To systematically analyze the chem. constituents of Citri Sarcodactylis Fructus (CSF) from different origins, an efficient approach based on ultraperformance liquid chromatog. plus Q-Exactive Orbitrap tandem mass spectrometry (UPLC-Q-Exactive Orbitrap/MS) detection for the discrimination of chem. components from of 15 batches of CSF from four main origins was used in this research. Through parent peaks, fragment peaks, fragmentation characteristics, and comparative anal. with the literature and reference standards, a total of 77 components from the methanol extracts including 18 coumarins, 24 flavonoids, seven organic acids, three limonoids, and 25 other compounds were detected and identified. Among them, 15 components have not been reported previously in the CSF. Notably, the stachydrine peak initially showed a higher content in the total ion current chromatogram. Overall, CSF produced in the Zhejiang province contained a richer variety of chem. compositions These observations provided a theor. basis for the further quality assessment and application of CSF. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Name: cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Satpute, Ravindra M.;Kushwaha, Pramod K.;Nagar, D. P.;Rao, P. V. L. published 《Comparative safety evaluation of riot control agents of synthetic and natural origin》 in 2018. The article was appeared in 《Inhalation Toxicology》. They have made some progress in their research.Application In Synthesis of N-Vanillylnonanamide The article mentions the following:

Riot control agents (RCA) are lachrymatory, irritating compounds which temporarily incapacitate the uncontainable crowd. Ortho-Chlorobenzylidene-malononitrile (CS), 2-chloroacetophenone (CN), dibenz[b,f]1:4-oxazepine (CR), and nonivamide (PAVA) are synthetic RCAs, while oleoresin extract of chili known as oleoresin capsicum (OC) a natural irritant has been in use by various law enforcement agencies. Though efficacy of these agents is beyond doubt, they suffer from certain drawbacks including toxicity, production cost, and ecol. compatibility. Presently, we have evaluated the safety of CR, OC, and PAVA on inhalation variables along with oral lethality. Addnl., the liver function test (LFT) in serum and lungs function was evaluated in broncho-alveolar-lavage fluid (BALF), both collected on the 14th day after RCA exposure. Animals then sacrificed and histopathol. of liver and lungs was carried out. Results showed OC and PAVA to be more toxic than CR with an oral LD₅₀ of 150 and 200 mg/kg body weight, resp., while CR was safe at >3 g/kg body weight All three agents caused severe impairment of respiratory variables bringing down normal respiration by >80% with rise in sensory irritation. Recovery from the irritating effect of CR was more rapid than OC and PAVA. LFT and BALF variables were not significantly different from that of control. There were no remarkable histopathol. changes in liver and lungs. Hence, as per results, CR is safest among all synthetic and natural origin RCAs and can be safely used for effective dispersion of disobedient mob. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Application In Synthesis of N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Takahashi, Bitoku;Funami, Hideaki;Shibata, Makoto;Maruoka, Hiroshi;Koyama, Makoto;Kanki, Satomi;Muto, Tsuyoshi published 《Structural optimization of ghrelin receptor inverse agonists to improve lipophilicity and avoid mechanism-based CYP3A4 inactivation》 in 2015. The article was appeared in 《Chemical & Pharmaceutical Bulletin》. They have made some progress in their research.COA of Formula: C6H7N3O The article mentions the following:

Structural optimization of 2-aminonicotinamide derivatives as ghrelin receptor inverse agonists is reported. So as to avoid mechanism-based inactivation (MBI) of CYP3A4, 1,3-benzodioxol ring of the lead compound was modified. Improvement of the main activity and lipophilicity was achieved simultaneously, leading to compound 18a, which showed high lipophilic ligand efficiency (LLE) and low MBI activity. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)COA of Formula: C6H7N3O is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rawson, Frankie J.;Downard, Alison J.;Baronian, Keith H. published 《Electrochemical detection of intracellular and cell membrane redox systems in Saccharomyces cerevisiae》 in 2014. The article was appeared in 《Scientific Reports》. They have made some progress in their research.Application of 329-89-5 The article mentions the following:

Redox mediators can interact with eukaryote cells at a number of different cell locations. While cell membrane redox centers are easily accessible, the redox centers of catabolism are situated within the cytoplasm and mitochondria and can be difficult to access. We have systematically investigated the interaction of thirteen commonly used lipophilic and hydrophilic mediators with the yeast Saccharomyces cerevisiae. A double mediator system is used in which ferricyanide is the final electron acceptor (the reporter mediator). After incubation of cells with mediators, steady state voltammetry of the ferri/ferrocyanide redox couple allows quantitation of the amount of mediator reduced by the cells. The plateau current at 425 mV vs Ag/AgCl gives the anal. signal. The results show that five of the mediators interact with at least three different trans Plasma Membrane Electron Transport systems (tPMETs), and that four mediators cross the plasma membrane to interact with cytoplasmic and mitochondrial redox mols. Four of the mediators inhibit electron transfer from S. cerevisiae. Catabolic inhibitors were used to locate the cellular source of electrons for three of the mediators. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Application of 329-89-5 is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hossen, Amjad Md.;Reza, A. S. M. Ali;Ahmed, A. M. Abu;Islam, Kamrul Md.;Jahan, Israt;Hossain, Rahni;Khan, Mohammad Forhad;Maruf, Mohammad Rifat Alam;Haque, Areeful Md.;Rahman, Atiar Md. published 《Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction》 in 2021. The article was appeared in 《Biomedicine & Pharmacotherapy》. They have made some progress in their research.Safety of cis-13-Docosenamide The article mentions the following:

Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems of medicine. The aim of the experiment reports the in vivo antiulcer activity of methanol extract of Blumea lacera (MEBLL) and in silico studies of bioactive constituents of MEBLL. In this study, fasted Long-Evans rat treated with 80 % ethanol (0.5 mL) to induce gastric ulcer, were pretreated orally with MEBLL at different doses (250 and 500 mg/kg, p.o., b.w) and omeprazole (20 mg/kg, p.o.) and distilled water were used as a reference drug and normal control resp. In silico activity against gastric H+-K+ATPase enzyme was also studied. The findings demonstrated that the treatment with MEBLL attenuated markedly ulcer and protected the integrity of the gastric mucosa by preventing the mucosal ulceration altered biochem. parameters of gastric juice such total carbohydrate, total protein and pepsin activity. Addnl., the exptl. groups significantly (p < 0.001) inhibited gastric lesions and malondealdehyde (MDA) levels and upregulated antioxidant enzymes level. Furthermore, nine compounds were documented as bioactive, displayed good binding affinities to against gastric H+-K+ATPase enzyme while these compounds illustrated inhibitory effect. From these studies, it is established MEBLL has ulcer healing property as unveiled by in vivo and in silico studies.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Safety of cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of cis-13-DocosenamideIn 2021, Guerrero-Castillo, Pedro;Reyes, Sarita;Acha, Otilia;Sepulveda, Beatriz;Areche, Carlos published 《Agro-industrial waste seeds from Peruvian Pouteria lucuma as new source of phytosterols》. 《LWT–Food Science and Technology》published the findings. The article contains the following contents:

Pouteria lucuma fruit is commonly used to prepare desserts, but it is also sold as pulp or flour. Then, huge amounts of its seeds are produced as agro-industrial waste, frequently eliminated. This study aims at analyzing the presence of all metabolites in Pouteria lucuma seed oil (LSO) by GC-MS and GC-FID. Several compounds were tentatively identified, such as fatty acids, fatty alcs., carotenes, phytosterols and tocopherols from LSO. A representative result was the high amount of β-sitosterol with 851.49 ± 1.29 mg/100 g of LSO, followed by stigmasterol with 75.42 ± 1.02 mg/100 g. Fatty acids with the highest content were oleic acid (13.57 ± 1.50 g/100 g of LSO), 9E-octadecenoic acid (6.85 ± 1.15 g/100 g of LSO), palmitic acid (5.44 ± 1.18 g/100 g of LSO) and stearic acid (2.12 ± 1.03 g/100 g of LSO). Therefore, metabolites tentatively identified in Pouteria lucuma seed oil have been linked to healthy properties based on a high amount of β-sitosterol present. This evidence could determine this agro-industrial waste with having beneficial properties, thus providing great added value. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Reference of cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 89-73-6《Synthesis and crystal structure of a heterobimetallic nickel-manganese 12-metallacrown-4 methanol disolvate monohydrate compound》 was published in 2020. The authors were Hall, Abigail J.;Zeller, Matthias;Zaleski, Curtis M., and the article was included in《Acta Crystallographica, Section E: Crystallographic Communications》. The author mentioned the following in the article:

The synthesis and crystal structure of the title compound [systematic name: di-μ-acetato-tetrakis(μ₄-N,2-dioxidobenzene-1-carboximidato)hexamethanoltetramanganese(III)nickel(II) methanol disolvate monohydrate], [Mn₄Ni(C₇H₄NO₃)₄(C₂H₃O₂)₂(CH₄O)₆]·₂CH₄O·H₂O or Ni(OAc)₂[12-MC_{Mn(III)N(shi)}-4](CH₃OH)₆·2CH₃OH·H₂O, where MC is metallacrown,^–OAc is acetate, and shi^3-is salicylhydroximate, are reported. The macrocyclic metallacrown is positioned on an inversion center located on the Ni^II ion that resides in the central MC cavity. The macrocycle consists of an Mn^III-N-O repeat unit that recurs four times to generate an overall square-shaped mol. Both the NiII and Mn^III ions are six-coordinate with an octahedral geometry. In addition, the Mn^III ions possess an elongated Jahn-Teller distortion along the z-axis of the coordination environment. The interstitial water mol. is slightly offset from and disordered about an inversion center. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Related Products of 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ren, Fang;Yang, Xiao;Hu, Zhong-Wen;Wong, Vincent Kam Wai;Xu, Hong-Yan;Ren, Ji-Hua;Zhong, Shan;Jia, Xiao-Jiong;Jiang, Hui;Hu, Jie-Li;Cai, Xue-Fei;Zhang, Wen-Lu;Yao, Fang-Long;Yu, Hai-Bo;Cheng, Sheng-Tao;Zhou, Hong-Zhong;Huang, Ai-Long;Law, Betty Yuen Kwan;Chen, Juan published 《Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production.》. The research results were published in《EBioMedicine》 in 2019.SDS of cas: 329-89-5 The article conveys some information:

BACKGROUND: Hepatitis B surface antigen (HBsAg) is one of the important clinical indexes for hepatitis B virus (HBV) infection diagnosis and sustained seroconversion of HBsAg is an indicator for functional cure. However, the level of HBsAg could not be reduced by interferons and nucleoside analogs effectively. Therefore, identification of a new drug targeting HBsAg is urgently needed. METHODS: In this study, 6-AN was screened out from 1500 compounds due to its low cytotoxicity and high antiviral activity. The effect of 6-AN on HBV was examined in HepAD38, HepG2-NTCP and PHHs cells. In addition, the antivirus effect of 6-AN was also identified in mouse model. FINDINGS: 6-AN treatment resulted in a significant decrease of HBsAg and other viral markers both in vitro and in vivo. Furthermore, we found that 6-AN inhibited the activities of HBV SpI, SpII and core promoter by decreasing transcription factor PPARα, subsequently reduced HBV RNAs transcription and HBsAg production. INTERPRETATION: We have identified a novel small molecule to inhibit HBV core DNA, HBV RNAs, HBsAg production, as well as cccDNA to a minor degree both in vitro and in vivo. This study may shed light on the development of a novel class of anti-HBV agent. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)SDS of cas: 329-89-5 is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Rongrong;Wang, Shuang;Zhang, Jiawei;Miao, Jing;Chen, Gangliang;Dong, Jing;Wu, Linying;Yue, Haitao;Yang, Jie published 《Untargeted metabolomics allows to discriminate raw camel milk, heated camel milk, and camel milk powder》. The research results were published in《International Dairy Journal》 in 2022.Name: cis-13-Docosenamide The article conveys some information:

The metabolomic profiles of raw camel milk (RCM), heated camel milk (HCM) and camel milk powder (CMP) were analyzed by ultra-high-performance liquid chromatog. coupled with quadrupole time of flight mass spectrometer (UHPLC-Q-TOF/MS). One hundred and nineteen significantly changed metabolites with variable importance for the projection (VIP) > 1 (t-test p < 0.05) from the pos. mode were selected and identified in RCM, HCM and CMP. These metabolites included saccharides, glycosylamines, adenosines, and phospholipid. Among the saccharides, the content of D-lactose was the highest and slightly increased after thermal treatment. Dipeptides, including His-Pro and Lys-Trp, were significantly increased in HCM and CMP. As for glycosylamines, the content of N-acetylneuraminic acid was the highest. The amounts of larixinic acid increased dramatically in HCM and CMP (p < 0.001), which may improve the flavor of camel milk. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Name: cis-13-Docosenamide It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Mingyang;Lian, De;Zhao, Fugang;Tong, Xiong;Wu, Chaoyang;Gao, Xiangpeng published 《Structure-activity of chelating depressants for chalcopyrite/pyrite separation: DFT study and flotation experiment》. The research results were published in《Physicochemical Problems of Mineral Processing》 in 2021.Category: amides-buliding-blocks The article conveys some information:

Three types of chelating depressants were studied for chalcopyrite/pyrite separation, including S-S, S-O, and O-O types, via d. functional theory calculations and microflotation. The calculation results indicate that the depressant’s chelating atoms have large coefficient and great activity according to the mol. frontier orbital (HOMO and LUMO) and the orbital coefficients For S-S type of depressant, S atom in both keto or enol forms won’t affect their HOMO and LUMO patterns and the orbital contributions. For S-O type, the presence of N atom in the ring structure of a mol. will increase the reactivity of O-Cu while weak S-Cu. For O-O type, the electron supply capacity of benzene ring is higher than strain chain, and atom N in strain chain increased their electron supply capacity. The microflotation results basically confirmed the prediction based on the calculation The simulation results demonstrate that the interaction of a depressant with metals and minerals are affected obviously by the spatial structure and electronic structure of an atom in its mol.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics