Month: September 2022

Kaiser, Mathias;Chalapala, Sudharani;Gorzelanny, Christian;Perali, Ramu Sridhar;Goycoolea, Francisco Martin published 《The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells》 in 2016. The article was appeared in 《Journal of Pharmaceutical Sciences》. They have made some progress in their research.Formula: C17H27NO3 The article mentions the following:

Capsaicin is known to interfere with tight junctions (TJs) of epithelial cells and therefore to enhance paracellular permeability of poorly absorbable drugs. However, due to its low water solubility, pungency, and cytotoxicity, its pharmacol. use is limited. In this study, the authors investigated the effect of capsaicin derivatives of synthetic (e.g., 10-hydroxy-N-(4-hydroxy-3-methoxybenzyl)decanamide, etc.) and natural (olvanil and dihydrocapsaicin) origin on Madin-Darby Canine Kidney-C7 cells. Impedance spectroscopy was used to determine the transepithelial elec. resistance and the capacitance. Permeability assays with fluorescein isothiocyanate-dextran were carried out to evaluate the impact on cell permeability. The results show that lipophilicity could play an important role for the interference with TJ and that the mechanism is independent from the ion channel TRPV-1 and hence on the flux of calcium into the cells. In summary, the authors synthesized 4 derivatives of capsaicin of lower lipophilicity and compared their properties with other well-known vanilloids. The authors show that these compounds are able to enhance the permeability of a hydrophilic macromol., by opening the TJ for a shorter time than capsaicin. This behavior is dependent on the lipophilicity of the mol. Understanding of these phenomena may lead to better control of administration of therapeutic mols. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Formula: C17H27NO3 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Chuan;Ma, Dianping;Cao, Wenming;Shi, Haiming;Jiang, Yuanrong published 《Fast simultaneous determination of capsaicin, dihydrocapsaicin and nonivamide for detecting adulteration in edible and crude vegetable oils by UPLC-MS/MS》 in 2018. The article was appeared in 《Food Additives & Contaminants, Part A》. They have made some progress in their research.Safety of N-Vanillylnonanamide The article mentions the following:

Capsaicinoids are pungent components in hot peppers, which have been detected in waste cooking oil. However, trace anal. of capsaicinoids in edible and crude vegetable oils is a challenging task due to the complex matrix. In this study, a simple liquid-liquid extraction and solid phase extraction (SPE) coupled with RP-UPLC-ESI-MS/MS method was developed for the quantification of capsaicinoids in edible and crude vegetable oils to screen the adulteration with waste cooking oil. This method was used to simultaneously determine 3 capsaicinoids (capsaicin, dihydrocapsaicin, and nordihydrocapsaicin) with capsaicin-d₃, and dihydrocapsaicin-d₃ as internal standards This method allows the complete anal. of a sample in only an hour, even including sample preparation and chromatog. separation The linear range of 3 capsaicinoids ranged between 0.5 and 40 μg/kg. The limit of detection (LOD) and limit of quantification (LOQ) for capsaicinoids were calculated as 0.15 and 0.5 μg/kg, resp. Quant. recoveries ranging from 92.9% to 105% were obtained by the anal. of spiked oil. The relative standard deviations were less than 5% (n = 6). The established method can potentially overcome the interference of triacylglycerols and fatty acids in edible and crude vegetable oils, and have been successfully applied to analyze real oil samples. This method provided a rapid and reliable method for the detection of adulteration of vegetable oils with waste cooking oils.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Safety of N-Vanillylnonanamide It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 6-Aminonicotinamide《SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells》 was published in 2021. The authors were Mason, Joshua A.;Cockfield, Jordan A.;Pape, Daniel J.;Meissner, Hannah;Sokolowski, Michael T.;White, Taylor C.;Valentin Lopez, Jose C.;Liu, Juan;Liu, Xiaojing;Martinez-Reyes, Inmaculada;Chandel, Navdeep S.;Locasale, Jason W.;Schafer, Zachary T., and the article was included in《Cell Reports》. The author mentioned the following in the article:

Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that affect cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM detachment. In addition, loss of ECM attachment causes profound alterations in cellular metabolism, which can lead to anoikis-independent cell death. Here, we describe a surprising role for serum and glucocorticoid kinase-1 (SGK1) in the promotion of energy production when cells are detached. Our data demonstrate that SGK1 activation is necessary and sufficient for ATP generation during ECM detachment and anchorage-independent growth. More specifically, SGK1 promotes a substantial elevation in glucose uptake because of elevated GLUT1 transcription. In addition, carbon flux into the pentose phosphate pathway (PPP) is necessary to accommodate elevated glucose uptake and PPP-mediated glyceraldehyde-3-phosphate (G3P) is necessary for ATP production Thus, our data show SGK1 as master regulator of glucose metabolism and cell survival during ECM-detached conditions. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Quality Control of 6-Aminonicotinamide is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of C17H27NO3In 2019, Sarpras, M.;Ahmad, Ilyas;Rawoof, Abdul;Ramchiary, Nirala published 《Comparative analysis of developmental changes of fruit metabolites, antioxidant activities and mineral elements content in Bhut jolokia and other Capsicum species》. 《LWT–Food Science and Technology》published the findings. The article contains the following contents:

Humans are directly or indirectly dependent on plant foods for their nutritional health. Hence it is important to characterize the macro and micro nutrients and mineral-elements of commonly consumed dietary vegetables like Capsicum (Chilli). In the present study global metabolites, total ascorbic acid, phenols, flavonoids, capsaicinoids, mineral-elements and antioxidant activities were determined on different developmental stages of Capsicum fruits (immature, breaker and mature) belonging to three Capsicum species namely Capsicum chinense, C. frutescens, and C. annuum. The results obtained from the present study showed the maturity dependent increase in the sugar and fatty acid metabolites, capsaicinoids, ascorbic acid and phenol content, and antioxidant activities. Similarly, essential mineral-elements also increased during the fruit maturation in C. chinense, however, contrasting results was observed in C. annuum. In addition to that some health beneficial compounds such as antibacterial and antifungal metabolites exclusively observed in matured C. chinense. These interesting observations have opened the possibility to understand and manipulate biosynthesis of macro/micronutrients and mineral elements in order to improve nutritional quality of Capsicum (Chilli) species.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Electric Literature of C17H27NO3 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palo-Nieto, Carlos;Afewerki, Samson;Anderson, Mattias;Tai, Cheuk-Wai;Berglund, Per;Cordova, Armando published 《Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis》. The research results were published in《ACS Catalysis》 in 2016.Recommanded Product: 2444-46-4 The article conveys some information:

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymic multiple relay catalysis for eco-friendly and asym. synthesis of valuable mols. (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biol. and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcs., resp.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Recommanded Product: 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Sujing;Zhou, Jun;Ma, Xuanxuan;Liu, Ying;Ma, Xing;Xia, Chuanhai published 《Ecotoxicity and preliminary risk assessment of nonivamide as a promising marine antifoulant》. The research results were published in《Journal of Chemistry》 in 2016.Category: amides-buliding-blocks The article conveys some information:

The unclear environmental performance of nonivamide limits its application as a marine antifoulant. In this study, the natural degradation of nonivamide was studied in seawater and tap water. The half-life was 5.8 d, 8.8 d, 12.2 d, and 14.7 d in seawater and tap water in photolysis and biolysis, resp. Furthermore, the ecotoxicity of nonivamide was assessed using marine microalgae, Chlorella vulgaris and Platymonas sp.; EC50,6 d values on the growth of Chlorella vulgaris and Platymonas sp. were 16.9 mg L^-1 and 19.21 mg L^-1, resp. The toxicity and environmental risk of nonivamide on microalgae were significantly decreased due to the natural degradation in seawater. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Category: amides-buliding-blocks Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Seo, Eunseok;Lee, Ji Woong;Lee, Dohoon;Seong, Myeong Ryun;Kim, Gwang Hoon;Hwang, Dong Soo;Lee, Sang Joon published 《Eco-friendly erucamide-polydimethylsiloxane coatings for marine anti-biofouling》. The research results were published in《Colloids and Surfaces, B: Biointerfaces》 in 2021.SDS of cas: 112-84-5 The article conveys some information:

Marine biofouling of ship hulls and ocean structures causes enormous economic losses due to increased frictional drag. Thus, efforts have been exerted worldwide to eliminate biofouling. In addition, a strong demand exists for the development of a cost-effective and eco-friendly anti-biofouling coating technol. Thus, erucamide-polydimethylsiloxane (EP) coating is proposed in this study. EP exhibits a hydrophobic surface as the erucamide content and drag reduction effect increase. In this study, the drag reduction effect of the EP 2.5 is better than that of glass and polydimethylsiloxane (PDMS) surfaces. Moreover, the proposed EP coatings are observed to prevent the biofouling induced by bacteria (E. coli) and brown algae (Cladosiphon sp.). In addition, through a marine field test, the anti-biofouling effect of the EP surface is found to be better than the previously studied oleamide-PDMS (OP) surface. In the marine field test, the EP 2.5 demonstrates superior anti-biofouling performance for 5.5 mo under real marine environment. The proposed eco-friendly EP coating method could be applicable to marine vehicles that require effective drag reduction and anti-biofouling properties.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.SDS of cas: 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 2444-46-4In 2021, Fadladdin, Yousef Abdal Jalil published 《Antischistosomal activity of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa plant extracts on hamster infected with Schistosoma haematobium》. 《BioMed Research International》published the findings. The article contains the following contents:

World Health Organization (WHO) has approved only one treatment for schistosomiasis, praziquantel (PZQ), but some poor efficacy was noticed in patients during the early stage of infection. Therefore, researchers have intensified their efforts to research new alternative medicines to treat schistosomiasis. In the present study, in vitro as well as in vivo studies have been accomplished to evaluate the effect of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa extracts in a different concentration 500, 250, 125, 62.5, and 31.25 μg/mL on golden hamster infected by Egyptian strains of schistosome (Schistosoma haematobium). In vitro, the adult worms and schistosomula of S. haematobium were investigated in RPMI-1640 medium for 48 h. The results showed that the concentration 500, 250, and 125 μg/mL of Origanum majorana, and Ziziphus spina-christi caused dead of 100% of Egyptian Schistosoma strains of adult worm and schistosomula of S. haematobium within 6 to 12 h of incubation. On the other hand, the extract of Salvia fruticosa at concentrations 500, 250, and 125 μg/mL showed death 100% parasites after 12 to 24 h of incubation. Inclusion, Origanum majorana, and Ziziphus spina-christi showed effectiveness against Egyptian Schistosoma strains (S. haematobium), a slight decrease in Salvia fruticosa was observed Therefore, these medical plant extracts may be used as a safe and effective treatment for schistosomiasis. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xie, Dandan;Yang, Zaiping;Hu, Xin;Wen, Yin published 《Synthesis, antibacterial and insecticidal activities of novel capsaicin derivatives containing a sulfonic acid esters moiety》 in 2022. The article was appeared in 《Frontiers in Chemistry (Lausanne, Switzerland)》. They have made some progress in their research.Product Details of 2444-46-4 The article mentions the following:

In order to develop an efficient and broad-spectrum bactericide, a series of novel capsaicin derivatives containing a sulfonic acid esters moiety was synthesized. The structure of these compounds were confirmed by NMR spectroscopy (NMR) and high-resolution mass spectrum (HRMS). The results of the bioactivities revealed that some target compounds exhibited remarkable antibacterial activity. Compound 3b exhibited the highest activities against Pseudomonas syringae pv. actinidiae (Psa), Xanthomonas oryzae pv. oryzae (Xoo), and Xanthomonas axonopodis pv. citri (Xac), and the values were 86, 54, and 92% at 50 μg/mL, resp., which were higher than were for thiodiazole copper (87, 34, and 77%) and bismerthiazol (87, 37 and 75%). Although some compounds also showed certain activity against Spodoptera frugiperda, it was weaker than the pos. controls monosultap and mulfoxaflor. Thus, the bioassay results recommend that these newly designed and synthesized scaffolds should be used as a bactericide lead compound rather than an insecticide lead compound And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chiang, Chengyao;Zhang, Min;Wang, Dian;Xiao, Tian;Zhu, Lizhi;Chen, Kai;Huang, Junrong;Huang, Jingying;Zhu, Jiang;Li, Li;Chen, Cheng;Chen, Yangchao;Hu, Hongyi;Jiang, Wenqi;Zou, Yongdong;Wang, Ting;Zheng, Duo published 《Therapeutic potential of targeting MKK3-p38 axis with capsaicin for nasopharyngeal carcinoma》. The research results were published in《Theranostics》 in 2020.Recommanded Product: 2444-46-4 The article conveys some information:

Background: Capsaicin is an active compound found in plants of the Capsicum genus; it has a range of therapeutic benefits, including anti-tumor effects. Here we aimed to delineate the inhibitory effects of capsaicin on nasopharyngeal carcinoma (NPC). Methods: The anti-cancer effects of capsaicin were confirmed in NPC cell lines and xenograft mouse models, using CCK-8, clonogenic, wound-healing, transwell migration and invasion assays. Co-immunoprecipitation, western blotting and pull-down assays were used to determine the effects of capsaicin on the MKK3-p38 axis. Cell proliferation and EMT marker expression were monitored in MKK3 knockdown (KD) or over-expression NPC cell lines treated with or without capsaicin. Finally, immunohistochem. was performed on NPC specimens from NPC patients (n = 132) and the clin. relevance was analyzed. Results: Capsaicin inhibited cell proliferation, mobility and promoted apoptosis in NPC cells. Then we found that capsaicin directly targets p38 for dephosphorylation. As such, MKK3-induced p38 activation was inhibited by capsaicin. Furthermore, we found that capsaicin-induced inhibition of cell motility was mediated by fucokinase. Xenograft models demonstrated the inhibitory effects of capsaicin treatment on NPC tumor growth in vivo, and anal. of clin. NPC samples confirmed that MKK3 phosphorylation was associated with NPC tumor growth and lymphoid node metastasis. Conclusions: The MKK3-p38 axis represents a potential therapeutic target for capsaicin. MKK3 phosphorylation might serve as a biomarker to identify NPC patients most likely to benefit from adjunctive capsaicin treatment. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Recommanded Product: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics