Quality Control of 4-MethylbenzenesulfonamideIn 2020 ,《Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Huang, Binbin; Yang, Chao; Zhou, Jia; Xia, Wujiong. The article contains the following contents:
A straightforward protocol for approaching N-sulfonylamidines (E/Z)-RS(O)2N=CHN(R1)(R2) (R = Me, 2-fluorophenyl, thiophen-2-yl, etc.; R1 = Me; R2 = Et, cyclohexyl, benzyl, etc.; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-) and I via an electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulfonamides RS(O)2NH2 and tertiary amines CH3N(R1)(R2), which features exclusive N-CH3 selectivity for the amine partners was reported. Mechanistic studies indicate that an in situ generated N-iodoaminium species serves as the key intermediate. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics