Schierle, Simone; Flauaus, Cathrin; Heitel, Pascal; Willems, Sabine; Schmidt, Jurema; Kaiser, Astrid; Weizel, Lilia; Goebel, Tamara; Kahnt, Astrid S.; Geisslinger, Gerd; Steinhilber, Dieter; Wurglics, Mario; Rovati, G. Enrico; Schmidtko, Achim; Proschak, Ewgenij; Merk, Daniel published the artcile< Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology>, SDS of cas: 1524-40-9, the main research area is zafirlukast urea synthesis antiinflammatory pharmacokinetics PPAR cysteinyl leukotriene receptor.
Multitarget design offers access to bioactive small mols. with potentially superior efficacy and safety. Particularly multifactorial chronic inflammatory diseases demand multiple pharmacol. interventions for stable treatment. By minor structural changes, we have developed a close analog of the cysteinyl-leukotriene receptor antagonist zafirlukast that simultaneously inhibits soluble epoxide hydrolase and activates peroxisome proliferator-activated receptor γ. The triple modulator exhibits robust anti-inflammatory activity in vivo and highlights the therapeutic potential of designed multitarget agents.
Journal of Medicinal Chemistry published new progress about Cysteinyl leukotriene receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (antagonists). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, SDS of cas: 1524-40-9.
Referemce:
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