Lescop, Cyrille; Herzner, Holger; Siendt, Herve; Bolliger, Reto; Henneboehle, Marco; Weyermann, Philipp; Briguet, Alexandre; Courdier-Fruh, Isabelle; Erb, Michael; Foster, Mark; Meier, Thomas; Magyar, Josef P.; Von Sprecher, Andreas published their research in Bioorganic & Medicinal Chemistry Letters on December 1 ,2005. The article was titled 《Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy》.Electric Literature of C13H26N2O4 The article contains the following contents:
Dipeptide-derived α-keto-amide compounds, e.g., I, with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC50 values down to 25 nM and exhibit greatly improved activity in muscle cells compared to the reference compound MDL28170. Several novel calpain inhibitors have shown pos. effects on histol. parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease. In the part of experimental materials, we found many familiar compounds, such as (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Electric Literature of C13H26N2O4)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Electric Literature of C13H26N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics