《Developmental toxicity of disinfection by-product monohaloacetamides in embryo-larval stage of zebrafish》 was published in Ecotoxicology and Environmental Safety in 2020. These research results belong to Ding, Xinliang; Zhu, Jingying; Zhang, Jie; Dong, Tianyu; Xia, Yankai; Jiao, Jiandong; Wang, Xinru; Zhou, Weijie. Quality Control of 2-Bromoacetamide The article mentions the following:
Developmental toxicity of disinfection byproduct monohaloacetamides in embryo-larval stage of zebrafish. Results showed that 80 mg/L CAcAm and 40 mg/L BAcAm significantly decreased the hatching rate, IAcAm decreased the hatching rate and delayed the hatching process in a concentration-dependent manner with an EC50 of 16.37 mg/L at 72 hpf. The frequency and severity order of morphol. abnormalities increased with the raised exposure concentrations and prolonged exposure time, and the corresponding EC50 at 96 hpf were 21.10, 9.77 and 16.60 mg/L for CAcAm, BAcAm and IAcAm, resp. MonoHAcAms exposure resulted in a time- and dose-dependent response in mortality and the calculated LC50 at 72 hpf were 38.44, 17.74 and 28.82 mg/L for CAcAm, BAcAm and IAcAm, resp. Based on EC50 for morphol. abnormalities and LC50, a toxicity rank order of BAcAm > IAcAm > CAcAm was observed Different degrees of hyperactivity and hypoactivity were observed from locomotor behavior anal. in larvae from ≤10.0 mg/L monoHAcAms exposure groups. The light-dark periodic change was disappeared in larvae of 10.0 mg/L BAcAm exposure group. In summary, our study showed that monoHAcAms were developmentally toxic to zebrafish even at very low concentrations and BAcAm exerted higher toxicity than IAcAm and CAcAm. These results will further our understanding of the toxicity of HAcAms and its potential toxicol. impact on human and ecol. environment. The results came from multiple reactions, including the reaction of 2-Bromoacetamide(cas: 683-57-8Quality Control of 2-Bromoacetamide)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Quality Control of 2-Bromoacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics