《Alkyne Versus Ynamide Reactivity: Regioselective Radical Cyclization of Yne-Ynamides》 was written by Dutta, Shubham; Mallick, Rajendra K.; Prasad, Rangu; Gandon, Vincent; Sahoo, Akhila K.. COA of Formula: C7H9NO2SThis research focused onyne tethered ynamide thiophenol regioselective radical cyclization; thioaryl pyrrole preparation; 4-thioaryl-pyrroles; 5-exo-dig cyclization; alkynes; radical cyclization; ynamides. The article conveys some information:
Ynamides are typically more reactive than simple alkynes and olefins. However, a serendipitous observation revealed a rare case where the reactivity of simple alkynes exceeds that of ynamides. This led to the development of a unique sulfur-radical-triggered cyclization of yne-tethered ynamides, which involves attack of the alkyne by a thiyl radical followed by cyclization with the ynamide. A wide range of novel 4-thioaryl pyrroles that could tolerate common functional moieties and N-protecting groups were expediently constructed by this strategy. The current method contrasts with the typical cyclization of yne-ynamides, which involves the attack of the alkyne moiety by the ynamide core. Control experiments and DFT calculations supported the participation of the sulfur radical in the reaction and the regioselective cyclization. The synthetic potential of the substituted pyrroles is also discussed. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C7H9NO2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics