In 2017,Ganiek, Maximilian A.; Becker, Matthias R.; Berionni, Guillaume; Zipse, Hendrik; Knochel, Paul published 《Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation》.Chemistry – A European Journal published the findings.Application of 78191-00-1 The information in the text is summarized as follows:
An ambient temperature continuous flow method for nucleophilic amidation and thioamidation was described. Deprotonation of formamides e.g., N,N-diethylformamide by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophiles such as ketones e.g., cyclohexanone, allyl bromides, Weinreb amides e.g., N-methoxy-N-methylacetamide and morpholino amides RC(O)R1 [R = C6H5, 4-FC6H4, CH(OC2H5)2, etc.; R1 = morpholin-4-yl]. The nature of the reactive lithium intermediates and the thermodn. of the metalation were further investigated by ab initio calculations and kinetic experiments In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Application of 78191-00-1)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 78191-00-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics