Hu, Yanhua; Zhang, Zhenfeng; Liu, Yangang; Zhang, Wanbin published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Cobalt-Catalyzed Chemo- and Enantioselective Hydrogenation of Conjugated Enynes》.SDS of cas: 78191-00-1 The article contains the following contents:
Asym. hydrogenation is one of the most powerful methods for the preparation of single enantiomer compounds However, the chemo- and enantioselective hydrogenation of the relatively inert unsaturated group in substrates possessing multiple unsaturated bonds remains a challenge. We herein report a protocol for the highly chemo- and enantioselective hydrogenation of conjugated enynes while keeping the alkynyl bond intact. Mechanism studies indicate that the accompanying Zn2+ generated from zinc reduction of the CoII complex plays a critical role to initiate a plausible CoI/CoIII catalytic cycle. This approach allows for the highly efficient generation of chiral propargylamines (up to 99.9% ee and 2000 S/C) and further useful chem. transformations. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 78191-00-1
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