Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn September 30, 1990 ,《Synthesis of 3-amino-4-phenylpyridines: a novel strategy for the preparation of CD ring models of streptonigrin》 was published in Journal of the Chemical Society. The article was written by Marsais, Francis; Rovera, Jean Claude; Turck, Alain; Godard, Alain; Queguiner, Guy. The article contains the following contents:
3-Amino-4-phenylpyridine derivatives were prepared 3-Pivaloylaminopyridines were lithiated by BuLi before reaction with iodine as electrophile to afford 4-iodo-3-pivaloylaminopyridines. Cross-coupling of the latter with suitable phenylboronic acids gives CD ring models e.g. I, of streptonigrin. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics