Morgan, Timaeus E. F.; Riley, Leanne M.; Tavares, Adriana A. S.; Sutherland, Andrew published an article in 2021. The article was titled 《Automated radiosynthesis of cis- and trans-4-[18F]fluoro-L-proline using [18F]Fluoride》, and you may find the article in Journal of Organic Chemistry.COA of Formula: C11H24N2O The information in the text is summarized as follows:
The positron emission tomog. imaging agents cis- and trans-4-[18F]fluoro-L-proline are used for the detection of numerous diseases such as pulmonary fibrosis and various carcinomas. These imaging agents are typically prepared by nucleophilic fluorination of 4-hydroxy-L-proline derivatives, with [18F]fluoride, followed by deprotection. Although effective radiofluorination reactions have been developed, the overall radiosynthesis process is suboptimal due to deprotection methods that are performed manually, require multiple steps, or involve harsh conditions. Here we describe the development of two synthetic routes that allow access to precursors, which undergo highly selective radiofluorination reactions and rapid deprotection, under mild acidic conditions. These methods were found to be compatible with automation, avoiding manual handling of radioactive intermediates. After reading the article, we found that the author used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8COA of Formula: C11H24N2O)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.COA of Formula: C11H24N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics