《A three component protocol for the synthesis of aziridines using BF3·(OEt)2》 was written by Basha, Shaik Firoj; Anwar, Shaik. Safety of 4-Methylbenzenesulfonamide And the article was included in Asian Journal of Chemistry in 2020. The article conveys some information:
Synthesis of syn and anti isomers of sulfonamides derivatives I [R = H, 4-F, 4-Cl, etc.; R1 = H, 4-Cl] was carried out by a three component reaction using phenacyl bromide, p-toluenesulfonamide and benzaldehydes in presence of mild Lewis acid such as BF3·(OEt)2 in dichloromethane. The synthetic utility of this protocol was carried out with syn-isomer to yield corresponding cis-aziridines. This protocol was operationally simple for a wide variety of substituted benzaldehydes and substituted phenacyl bromides. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Safety of 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics