Application of 70-55-3In 2019 ,《Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide》 appeared in Journal of Organic Chemistry. The author of the article were Mahato, Sachinta; Santra, Sougata; Zyryanov, Grigory V.; Majee, Adinath. The article conveys some information:
A novel and efficient approach has been developed to synthesize α-sulfonylamino ketones, e.g., PhCOCH2NHTs, through the reaction between terminal alkynes and sulfonamides under ambient air using diacetoxy iodobenzene. A library of α-sulfonylamino ketone derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room temperature reaction conditions under ambient air and is operationally simple. A gram-scale synthesis demonstrates the potential applications of the present method. In addition, we have also synthesized α-acetoxy ketones, e.g., PhCOCH2OAc, in the absence of sulfonamide. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Application of 70-55-3)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 70-55-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics