《Self-assembled Ln(III) cyclen-based micelles and AuNPs conjugates as candidates for luminescent and magnetic resonance imaging (MRI) agents》 was written by Molloy, Jennifer K.; Nonat, Aline M.; O’Brien, John E.; Brougham, Dermot F.; Gunnlaugsson, Thorfinnur. Formula: C2H4BrNO And the article was included in Supramolecular Chemistry in 2020. The article conveys some information:
The tetra-substituted heptadentate cyclen (1,4,7,10-tetraazacyclododecane) based Eu(III)/Tb(III)/Gd(III)-complexes 1.Ln and 2.Ln were developed. An 1.Eu/Tb and 2.Eu/Tb and were employed in the formation of luminescent self-assembling ternary structures, and we demonstrate that only in the presence of appropriate sensitizing antennae, was the lanthanide-emission of 1.Eu/Tb and 2.Eu/Tb ‘switched on’. An 1.Gd/2.Gd were developed as potential MIR contrast agents, and employed in NMRD-measurements, where their relaxivity was investigated, and their (relatively high) r1 values determined The formation of a self-assembled micelle-type structure was clearly observed for 2.Gd. The functionalised gold nanoparticles 1.Ln-AuNP were also synthesized from 1.Ln. As for the free complexes, the Ln-emission was ‘switched on’ for 1.Eu/Tb-AuNP in the presence of the antennae. NMRD measurements indicated that the relaxivity for the 1.Gd-AuNP systems was very high, with a value of 445 s-1mM-1 (at 400 MHz), demonstrating the cumulative effect of the relatively high number of 1.Gd complexes on the surface of the AuNP. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Formula: C2H4BrNO)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Formula: C2H4BrNO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics