Hu, Xiao-Qiang; Hou, Ye-Xing; Liu, Zi-Kui; Gao, Yang published an article in 2021. The article was titled 《Ruthenium-catalyzed C-H/C-N bond activation: facile access to isoindolinones》, and you may find the article in Organic Chemistry Frontiers.Name: 4-Methylbenzenesulfonamide The information in the text is summarized as follows:
A facile ruthenium-catalyzed C-H/C-N bond activation and the subsequent annulation of readily available benzoic acids with in situ generated formaldimines was reported. The choice of solvent and base was critical for this reaction. This protocol allowed the efficient synthesis of a wide range of biol. important isoindolinones I [R = Ts, 4-ClC6H4SO2, 4-t-BuC6H4SO2, 4-F3COC6H4SO2; R1 = H, Me, Ph, etc.; R2 = H, Br, OPh, etc.; R3 = H, n-Bu, Cl, etc.; R4 = H, Cl, Br; R1R2 = (CH2)4; R2R3 = CH=CH-CH=CH] in useful to excellent yields without the use of any external oxidants. The late-stage modification of bioactive acids such as adapalene, bexarotene and flufenamic acid demonstrated the synthetic utility of this methodol. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics