Kubasov, Alexey S.; Turyshev, Evgeniy S.; Novikov, Ivan V.; Gurova, Olga M.; Starodubets, Polina A.; Golubev, Aleksei V.; Zhizhin, Konstantin Yu.; Kuznetsov, Nikolay T. published their research in Polyhedron in 2021. The article was titled 《Theoretical and experimental comparison of the reactivity of the sulfanyl-closo-decaborate and sulfanyl-closo-dodecaborate anions and their mono-S-substituted derivatives》.Application In Synthesis of 2-Bromoacetamide The article contains the following contents:
In this work, we have extended the method proposed by Gabel for the preparation of mono- and di-S,S-substituted derivatives of sulfanyl-closo-dodecaborate anion [B12H11SH]2- to derivatives of the closo-decaborate anion. The method is based on the β-elimination of the propionitrile group of sulfonium derivatives [BnHn-1S(R)CH2CH2CN]- in the presence of bases with the formation of the corresponding mono-S-substituted derivatives and acrylonitrile. We also calculated the Fukui functions for the nucleophilic attack of the S-atom in the [B10H9SH]2- and [B12H11SH]2- anions and their mono-S-substituted derivatives using the Hirshfeld approach. As a result, the calculated value of nucleophilicity in the [B10H9SH]2- anion was found to be 5-10 times lower than in other compounds, which completely agrees with the exptl. data. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide) was used in this study.
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics