《A practical and total synthesis of pasireotide: Synthesis of cyclic hexapeptide via a three-component condensation》 was published in Molecules in 2019. These research results belong to Ma, Chunying; Chen, Miao; Chu, Weiming; Tao, Jiayi; Kong, Delong; Zhang, Mengmeng; Feng, Wenhua. Application In Synthesis of H-Lys(Boc)-OH The article mentions the following:
Pasireotide is a multi-receptor ligand somatostatin analog approved for medical treatment of Cushing’s disease and acromegaly. The liquid-phase total synthesis of pasireotide-a 18-membered cyclic hexapeptide-was achieved by the 3 + 2 + 1 strategy, and the Pro1 -Phe6 peptide bond was selected as the final cyclization position. Two key fragments were simply synthesized using N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester (BSA/NHS) as coupling agents, and processes of the two key fragments were simple without any chromatog. purification The current synthesis method is easily scalable and produces the target peptide with an overall yield of 15%. In the experiment, the researchers used many compounds, for example, H-Lys(Boc)-OH(cas: 2418-95-3Application In Synthesis of H-Lys(Boc)-OH)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Application In Synthesis of H-Lys(Boc)-OH
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics