On July 9, 2009, De Vries, Andreas Hendrikus Maria; Domin, Doris; Helms, Matthias; Imboden, Christoph; Koberstein, Ralf; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Gerardus Karel Maria published a patent.Synthetic Route of 65645-88-7 The title of the patent was Process for preparation of (S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydro-1H-isoquinoline acetate via asymmetric hydrogenation. And the patent contained the following:
(S)-6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-1,2,3,4-tetrahydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), (S)-1-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]ferrocene, iodine, and a solvent under 1-200 bar H2. The above reaction was carried out at 5 bar H2 and 30° in CH2Cl2 with a I2/Ir ratio of 2:1 to give the title product in 95% enantiomeric excess with 100% conversion. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Synthetic Route of 65645-88-7
The Article related to phenethyldihydroisoquinoline asym hydrogenation iridium phosphinoferrocene catalyst, methoxytrifluoromethylphenylethyltetrahydroisoquinoline acetate chiral preparation, almorexant hydrochloride preparation and other aspects.Synthetic Route of 65645-88-7
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