On March 31, 2021, Gouda, Moustafa A.; Barnawi, Ibrahim O. published an article.Related Products of 144-80-9 The title of the article was Synthesis and cytotoxic activity of some new pyrazolo[1,5-a]pyrimidine derivatives. And the article contained the following:
A series of arylazopyrazolones II [R = amino, hydroxy, acetamido, etc] was synthesized through treatment of the 3-aminopyrazolin-5-one with the appropriate diazonium salts, followed by cyclization of the resulted arylazopyrazolones II [R = hydroxy, (4,6-dimethylpyrimidin-2-yl)amino] and I [R = (4,6-dimethylpyrimidin-2-yl)amino] with acetylacetone in boiling acetic acid. Using doxorubicin as the reference drug, the in-vitro cytotoxic activity of the synthetic arylazopyrazoles II [R = amino, hydroxy, acetamido, etc] and I [R = amino, thiazol-2-ylamino, (4,6-dimethylpyrimidin-2-yl)amino] was evaluated on four human cell lines. The results revealed that compounds II [R = amino, hydroxy, acetamido, etc] revealed good cytotoxic activity toward HepG2, HCT-116, MCF-7, and PC3 cell lines, within IC50 5.89±0.4-19.23±1.6; 7.15±0.6-23.15±1.8; 4.93±0.4-24.35±1.9; and 9.14±0.8-32.09±2.0μg/mL. The derivatives II [R = amino, acetamido, guanidino] displayed accurate anticancer activity toward all most cancers cell lines, even as compounds I [R = thiazol-2-ylamino] exhibited moderate activities, while the pyrazolopyrimidine I [R = amino] has lower anticancer activity. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9
The Article related to aryl diazonium chloride aminopyraxolone coupling reaction, oxo aminopyrzolyl sulfonylphenyl hydrazine preparation acetyl acetone heterocyclization, dimethyl oxo dihydropyrazolopyrimidinyl diazenylbenzenesulfonamide preparation antitumor sar and other aspects.Related Products of 144-80-9
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics