On October 15, 2021, Wang, Zhiguo; Li, Shijiang; Li, Ronghao; Luo, Chunyan published a patent.Formula: C6H11NO The title of the patent was Preparation of indoline-5-methylamine dihydrochloride from indole. And the patent contained the following:
The present invention relates to the preparation of indoline-5-methylamine dihydrochloride from indole. In particular, the preparation method comprises of following steps: (1) using indole as a raw material, and reacting with an acid to obtain a formyl-protected indoline; (2) carrying out Friedel-Crafts reaction of the formyl protected indoline with an amination reagent to obtain 5-[(1,3-dioxoisoindolin-2-yl)methyl]indole-1-carbaldehyde; (3) the obtained intermediate compound is treated with hydrazine hydrate to obtain 5-(aminomethyl)indole-1-aminoaldehyde; and (4) carrying out the deprotection reaction of 5-(aminomethyl)indole-1-aminoaldehyde to obtain the target product indoline-5-methylamine dihydrochloride. The inventive method has a short process route, low cost, easy availability of raw materials and auxiliary materials, high reactivity, simple operation, easy control, and has high yield of the target product, which is convenient for industrial scale-up. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Formula: C6H11NO
The Article related to indole formic acid formylation reduction, formylindoline preparation hydroxymethyl phthalimide compound friedel crafts reaction, dioxyisoindolinyl methylindole formaldehyde preparation amination, aminomethyl dihydro indole carboxaldehyde preparation deprotection, indoline methylamine dihydrochloride preparation and other aspects.Formula: C6H11NO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics