On January 14, 2010, De Vries, Maria Andreas Hendrikus; Domin, Doris; Helms, Matthias; Imboden, Chistoph; Koberstein, Ralph; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Maria Gerardus Karel; Stichler, Juergen published a patent.Formula: C9H11NO2 The title of the patent was Process and intermediates for preparation of almorexant hydrochloride.. And the patent contained the following:
(S)-6,7-Dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydroisoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), taniaphos, and I2 in a solvent at 1-200 bar H2. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Formula: C9H11NO2
The Article related to almorexant hydrochloride preparation, methoxytrifluoromethylphenylethyldihydroisoquinoline acetate chiral preparation, hydroisoquinoline asym hydrogenation taniaphos cyclopentadiene iridium chloride and other aspects.Formula: C9H11NO2
Referemce:
Amide – Wikipedia,
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