On May 31, 2021, Jokioja, Johanna; Percival, Jasmine; Philo, Mark; Yang, Baoru; Kroon, Paul A.; Linderborg, Kaisa M. published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was Phenolic Metabolites in the Urine and Plasma of Healthy Men After Acute Intake of Purple Potato Extract Rich in Methoxysubstituted Monoacylated Anthocyanins. And the article contained the following:
Structurally stable acylated anthocyanins have potential in various food applications but the effects of acylation and methoxysubstitution on anthocyanin metabolism are poorly understood. This is the first study thoroughly investigating phenolic metabolites, their time-wise changes, and pharmacokinetics following an acute intake of methoxysubstituted monoacylated anthocyanins. Healthy male volunteers (n = 17) consumed a yellow potato meal with and without purple potato extract rich in acylated anthocyanins (152 mg) and hydroxycinnamic acid conjugates (140 mg). Ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) is used for identification and quantification of metabolites from serially collected urine and plasma. While the parent anthocyanins are not detected, 28 phenolic metabolites from urine and 14 from plasma are quantified, including hydroxybenzoic and hydroxycinnamic acids and protocatechuic acid sulfates and glucuronides; three (catechol, gallic acid-4-O-glucuronide, and 2-methoxybenzoic acid) are detected for the first time after anthocyanin-rich food. Urinary hippuric acid is the most abundant with an increase of 139 μM mM-1 creatinine after the treatment. A large addnl. set of tentatively identified phenolic metabolites are detected. Late urinary peak time values suggest colonic degradation Acylated anthocyanins are more bioavailable than earlier reported after extensive degradation in human and/or colonial metabolism to phenolic metabolites, which may be further conjugated and demethylated. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid
The Article related to phenolic metabolite urine plasma purple potato extract anthocyanin, solanum tuberosum l., acylated anthocyanins, mass spectrometry, postprandial metabolites, purple-fleshed potatoes and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid
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