Valderrey, Virginia’s team published research in Angewandte Chemie, International Edition in 2017 | CAS: 78191-00-1

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N-Methoxy-N-methylacetamide

In 2017,Valderrey, Virginia; Bonasera, Aurelio; Fredrich, Sebastian; Hecht, Stefan published 《Light-Activated Sensitive Probes for Amine Detection》.Angewandte Chemie, International Edition published the findings.Recommanded Product: N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

The authors’ new, simple, and accurate colorimetric method is based on diarylethenes (DAEs) for the rapid detection of a wide range of primary and secondary amines. The probes consist of aldehyde- or ketone-substituted diarylethenes, which undergo an amine-induced decoloration reaction, selectively to give the ring-closed isomer. Thus, these probes can be activated at the desired moment by light irradiation, with a sensitivity that allows the detection of amines at concentrations as low as 10-6 M in solution In addition, the practical immobilization of DAEs on paper makes it possible to detect biogenic amines, such as cadaverine, in the gas phase above a threshold of 12 ppbv within 30 s. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bosnidou, Alexandra E.’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 70-55-3

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C7H9NO2S

In 2019,Angewandte Chemie, International Edition included an article by Bosnidou, Alexandra E.; Muniz, Kilian. Computed Properties of C7H9NO2S. The article was titled 《Intermolecular Radical C(sp3)-H Amination under Iodine Catalysis》. The information in the text is summarized as follows:

Alkanes and aryl alkanes such as ethylbenzene underwent regioselective amination with sulfonamides such as trifluoromethanesulfonamide in the presence of I2 using iodobenzene bis(4-bromobenzoate) as the stoichiometric oxidant in anhydrous dichloromethane under blue LED irradiation to yield N-sulfonyl benzylic and alkyl amines such as PhCH(NHTf)Me. The method was used to prepare aminated amino acids and racemic arylglycinates and β-aryl-β-alaninates as well as memantine, rasagiline, and racemic sertraline. The method was also used to prepare trans-2,5-disubstituted pyrrolidines by iodine-catalyzed photochem. amination of phenylalkanes with methanesulfonamide followed by intramol. amination in the presence of I2 using phenyliodine bis(3-chlorobenzoate) as the stoichiometric oxidant; the method was also used to prepare the dibenzoazabicyclooctane anticonvulsant MK-801. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

de Jesus Cruz, Pedro’s team published research in Science (Washington, DC, United States) in 2022 | CAS: 78191-00-1

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C4H9NO2

In 2022,de Jesus Cruz, Pedro; Cassels, William R.; Chen, Chun-Hsing; Johnson, Jeffrey S. published an article in Science (Washington, DC, United States). The title of the article was 《Doubly stereoconvergent crystallization enabled by asymmetric catalysis》.Synthetic Route of C4H9NO2 The author mentioned the following in the article:

Herein, discovery and development of a catalyst-mediated asym. Michael addition/crystallization-induced diastereomer transformation of broad scope was reported. The sequence controlled three stereogenic centers, two of which were stereochem. labile. The configurational instability of 1,3-dicarbonyls and nitroalkanes, typically considered a liability in stereoselective synthesis, was productively leveraged by merging enantioselective Bronsted base organocatalysis and thermodn. stereocontrol using a single convergent crystallization The synthesis of useful γ-nitro β-keto amides containing three contiguous stereogenic centers was thus achieved from Michael acceptors containing two prochiral centers. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

McCutcheon, David C.’s team published research in Journal of the American Chemical Society in 2020 | CAS: 2418-95-3

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application In Synthesis of H-Lys(Boc)-OH

McCutcheon, David C.; Lee, Gihoon; Carlos, Anthony; Montgomery, Jeffrey E.; Moellering, Raymond E. published an article on January 8 ,2020. The article was titled 《Photoproximity Profiling of Protein-Protein Interactions in Cells》, and you may find the article in Journal of the American Chemical Society.Application In Synthesis of H-Lys(Boc)-OH The information in the text is summarized as follows:

We report a novel photoproximity protein interaction (PhotoPPI) profiling method to map protein-protein interactions in vitro and in live cells. This approach utilizes a bioorthogonal, multifunctional chem. probe that can be targeted to a genetically encoded protein of interest (POI) through a modular SNAP-Tag/benzylguanine covalent interaction. A first generation photoproximity probe, PP1, responds to 365 nm light to simultaneously cleave a central nitroveratryl linker and a peripheral diazirine group, resulting in diffusion of a highly reactive carbene nucleophile away from the POI. We demonstrate facile probe loading, and subsequent interaction- and light-dependent proximal labeling of a model protein-protein interaction (PPI) in vitro. Integration of the PhotoPPI workflow with quant. LC-MS/MS enabled unbiased interaction mapping for the redox regulated sensor protein, KEAP1, for the first time in live cells. We validated known and novel interactions between KEAP1 and the proteins PGAM5 and HK2, among others, under basal cellular conditions. By contrast, comparison of PhotoPPI profiles in cells experiencing metabolic or redox stress confirmed that KEAP1 sheds many basal interactions and becomes associated with known lysosomal trafficking and proteolytic proteins like SQSTM1, CTSD, and LGMN. Together, these data establish PhotoPPI as a method capable of tracking the dynamic subcellular and protein interaction “”social network”” of a redox-sensitive protein in cells with high temporal resolution The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Application In Synthesis of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application In Synthesis of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Xiaojie’s team published research in Journal of Drug Delivery Science and Technology in 2021 | CAS: 2418-95-3

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).HPLC of Formula: 2418-95-3

Song, Xiaojie; Lan, Kangli; Lv, Qi-Yan; Liu, Hongmin; Cui, Hui-Fang published an article on February 28 ,2021. The article was titled 《Genipin cross-linked blue Lys-FA nanoparticles for targeted visible glioma cell staining and drug delivery》, and you may find the article in Journal of Drug Delivery Science and Technology.HPLC of Formula: 2418-95-3 The information in the text is summarized as follows:

Design and fabrication of multifunctional nano-carrier is a promising tool in the field of nanomedicine for glioma theranostics. In this study, blue color nanoparticles with targeted tumor cell staining and drug delivery capabilities were simply fabricated by crosslinking lysine (Lys) and lysine-folic acid (Lys-FA) mixture with genipin as the crosslinking agent through a reversed microemulsion method. Doxorubicin (DOX) as the model drug was loaded through electrostatic interaction. The nanoparticles before (Lys-FA NPs) and after (Lys-FA/DOX NPs) loading of DOX were characterized by UV-visible (UV-Vis) spectroscopy, Fourier transform IR spectroscopy (FTIR), dynamic laser light scattering (DLS), transmission electron microscopy (TEM), and fluorescence spectroscopy. Ultimately, the glioma cell staining ability of Lys-FA NPs and cytotoxicity of Lys-FA/DOX NPs were tested in vitro. The results showed that the particle size of Lys-FA NPs can be tuned by adjusting the ratio of Lys to Lys-FA simply. The Lys-FA NPs exhibited dark blue and the blue color is stable under different pH values and temperatures The feature makes the staining glioma cell pellets visible to naked-eyes. The model drug DOX was loaded on Lys-FA NPs indicated by the increase of size and zeta potential, and change of optical properties. The DOX loaded on the Lys-FA NPs can be sustainedly released, other than burst release. Encouragingly, the Lys-FA NPs can deliver DOX into cells and dramatically reduce cell viability, as proved by U87 cell cytotoxicity anal. and confocal fluorescence imaging. In addition, the Lys-FA NPs (≤2.5 mg mL-1) are nontoxic to CHO cells. In a short, the blue color Lys-FA NPs can visibly stain glioma cell pellets and deliver DOX into glioma cells, which can potentially be applied as a multifunctional nanocarrier for tumor imaging and drug delivery. In the experiment, the researchers used many compounds, for example, H-Lys(Boc)-OH(cas: 2418-95-3HPLC of Formula: 2418-95-3)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).HPLC of Formula: 2418-95-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Yu’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 2418-95-3

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).COA of Formula: C11H22N2O4

The author of 《Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities》 were Zhang, Yu; Song, Wenliang; Li, Shuwei; Kim, Dae-Kyoung; Kim, Jae Ho; Kim, Jung Rae; Kim, Il. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2020. COA of Formula: C11H22N2O4 The author mentioned the following in the article:

A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. The topol. nanoengineered polypeptides show superior antimicrobial activity against Gram-pos. and Gram-neg. bacteria and low toxicity, allowing screening of architectural polypeptides as mimics of host defense peptides for antimicrobials. In the experiment, the researchers used many compounds, for example, H-Lys(Boc)-OH(cas: 2418-95-3COA of Formula: C11H22N2O4)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).COA of Formula: C11H22N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ziegler, Dorothee S.’s team published research in Angewandte Chemie, International Edition in 2018 | CAS: 78191-00-1

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C4H9NO2

In 2018,Angewandte Chemie, International Edition included an article by Ziegler, Dorothee S.; Karaghiosoff, Konstantin; Knochel, Paul. Synthetic Route of C4H9NO2. The article was titled 《Generation of Aryl and Heteroaryl Magnesium Reagents in Toluene by Br/Mg or Cl/Mg Exchange》. The information in the text is summarized as follows:

The alkylmagnesium alkoxide sBuMgOR·LiOR (R = 2-ethylhexyl), which was prepared as a 1.5M solution in toluene, undergoes very fast Br/Mg exchange with aryl and heteroaryl bromides, producing aryl and heteroaryl magnesium alkoxides (ArMgOR·LiOR) in toluene. These Grignard reagents react with a broad range of electrophiles, including aldehydes, ketones, allyl bromides, acyl chlorides, epoxides, and aziridines, in good yields. Remarkably, the related reagent sBu2Mg·2LiOR (R = 2-ethylhexyl) undergoes Cl/Mg exchange with various electron-rich aryl chlorides in toluene, producing diorganomagnesium species of type Ar2Mg·2LiOR, which react well with aldehydes and allyl bromides. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hayashi, Eri’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 70-55-3

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C7H9NO2S

《One-pot aerobic oxidative sulfonamidation of aromatic thiols with ammonia by a dual-functional β-MnO2 nanocatalyst》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Hayashi, Eri; Yamaguchi, Yui; Kita, Yusuke; Kamata, Keigo; Hara, Michikazu. Electric Literature of C7H9NO2S The article mentions the following:

High-surface-area β-MnO2nanoparticles could act as effective heterogeneous catalysts for the one-pot oxidative sulfonamidation of various aromatic and heteroaromatic thiols to give corresponding sulfonamides ArSO2NH2 [Ar = Ph, 2-thienyl, 4-BrC6H4, etc.] using mol. oxygen and ammonia as resp. oxygen and nitrogen sources, without the need for any additives. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Orooji, Yasin’s team published research in International Journal of Biological Macromolecules in 2021 | CAS: 70-55-3

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4-Methylbenzenesulfonamide

Orooji, Yasin; Pakzad, Khatereh; Nasrollahzadeh, Mahmoud; Tajbakhsh, Mahmood published an article in 2021. The article was titled 《Novel magnetic lignosulfonate-supported Pd complex as an efficient nanocatalyst for N-arylation of 4-methylbenzenesulfonamide》, and you may find the article in International Journal of Biological Macromolecules.Recommanded Product: 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

This study presented a novel and economical technique for synthesizing magnetic palladium complex conjugated to activated calcium lignosulfonate with triethylenetetramine (Fe3O4@lignosulfonate@triethylenetetramine@Pd complex (FLT-Pd complex)) as a practical and air-stable catalyst. FLT-Pd complex was used as a catalyst for the fabrication of 4-methyl-N-aryl-benzenesulfonamide derivatives I [Ar = Ph, 4-MeC6H4, 2-H2NC6H4, etc.] via N-arylation of 4-methylbenzenesulfonamide with aryl halides in good yields. Furthermore, because of the complex magnetic reparability and high stability, it could be removed easily from the reaction media using a magnet and reused 5 cycles without a remarkable loss of catalytic prowess. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ganesh Kumar, Mothukuri’s team published research in European Journal of Organic Chemistry in 2015 | CAS: 87694-50-6

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

《Synthesis of tetrasubstituted symmetrical pyrazines from β-keto γ-amino esters: A mild strategy for self-dimerization of peptides》 was written by Ganesh Kumar, Mothukuri; Thombare, Varsha J.; Bhaisare, Rupal D.; Adak, Anindita; Gopi, Hosahudya N.. Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide And the article was included in European Journal of Organic Chemistry in 2015. The article conveys some information:

A facile synthesis of highly sym. tetrasubstituted pyrazines through simple aerial oxidation of β-keto γ-amino esters is reported. The scope of the reaction was examined by use of various amino acid side-chain functional groups and peptides. The mild and efficient transformation of β-keto γ-amino esters into pyrazines may serve as an attractive strategy for self-dimerization of peptides. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Application In Synthesis of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics