Month: October 2022

《Treating water containing elevated bromide and iodide levels with granular activated carbon and free chlorine: impacts on disinfection byproduct formation and calculated toxicity》 was published in Environmental Science: Water Research & Technology in 2020. These research results belong to Zhang, Chuhui; Maness, J. Clark; Cuthbertson, Amy A.; Kimura, Susana Y.; Liberatore, Hannah K.; Richardson, Susan D.; Stanford, Benjamin D.; Sun, Mei; Knappe, Detlef R. U.. SDS of cas: 683-57-8 The article mentions the following:

We evaluated the efficacy of granular activated carbon (GAC) adsorption for mitigating formation of chlorine disinfection byproducts (DBPs) in water with a wide range of bromide (20-1000μg L-1) and iodide (<5-100μg L-1) concentrations GAC effectiveness was assessed by determining speciated total organic halogen (TOX), 70 DBPs, and calculated cyto- and genotoxicity. Overall, GAC treatment effectively lowered formation of TOX and the majority of targeted DBPs over the evaluated service time (>30 000 bed volumes). In the GAC influent, total organic bromine increased from 10 to 84% of TOX as bromide levels increased from 20 to 1000μg L-1. Dissolved organic carbon (DOC) removal by GAC increased the bromide-to-DOC (Br/DOC) concentration ratio in GAC effluent relative to influent. As a result, bromine incorporation into DBPs increased after GAC treatment, especially at early GAC service times and low bromide levels. Total organic iodine was <3.5% of TOX, and iodo-DBP formation was low because elevated iodide was only evaluated in the presence of high bromide and free chlorine, a scenario that favors iodate formation. Although trihalomethanes (THMs) and haloacetic acids (HAAs) consistently formed at the highest molar concentrations, they were not major contributors to calculated cyto- and genotoxicity. Principal contributors to calculated cytotoxicity included haloacetaldehydes (HALs), haloacetamides (HAMs), and haloacetonitriles (HANs), while the main drivers of genotoxicity were HALs, HAMs, HANs, and halonitromethanes (HNMs) despite lower concentrations Because bromine incorporation into DBPs increased nonlinearly with increasing Br/DOC concentration ratios, GAC more effectively controlled calculated toxicity at elevated bromide levels. Calculated cyto- and genotoxicity did not vary strongly with GAC service life, suggesting that GAC treatment can effectively lower calculated toxicity over long periods of operation. The majority of TOX remained unknown (>50%) in all samples despite the quantification of 70 DBPs targeted in this study, highlighting the need to assess toxicity associated with unknown DBPs. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8SDS of cas: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.SDS of cas: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Copper-catalyzed tandem cis-carbometalation/cyclization of imine-ynamides with arylboronic acids》 was written by Wang, Hao-Ran; Huang, En-He; Luo, Chen; Luo, Wen-Feng; Xu, Yin; Qian, Peng-Cheng; Zhou, Jin-Mei; Ye, Long-Wu. Related Products of 70-55-3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Indoles I (Ar1, Ar2 = Ph, substituted Ph; X = H, OMe, Me, Br) were prepared by copper(I) acetate-catalyzed tandem carboboration-cyclization of imino-ynamides 2-tBuN:CHC6H4N(PG)CCAr1 (PG = arenesulfonyl) with areneboronic acids Ar2B(OH)2. An efficient copper-catalyzed tandem regioselective cis-carbometalation/cyclization of imine-ynamides with arylboronic acids has been developed. This method leads to a facile and practical synthesis of valuable 2,3-disubstituted indolines in moderate to excellent yields and features a broad substrate scope and wide functional group tolerance. Other significant features of this protocol include the use of readily available starting materials, high flexibility, simple procedure and mild reaction conditions. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 4-MethylbenzenesulfonamideIn 2020 ,《Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Huang, Binbin; Yang, Chao; Zhou, Jia; Xia, Wujiong. The article contains the following contents:

A straightforward protocol for approaching N-sulfonylamidines (E/Z)-RS(O)2N=CHN(R1)(R2) (R = Me, 2-fluorophenyl, thiophen-2-yl, etc.; R1 = Me; R2 = Et, cyclohexyl, benzyl, etc.; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-) and I via an electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulfonamides RS(O)2NH2 and tertiary amines CH3N(R1)(R2), which features exclusive N-CH3 selectivity for the amine partners was reported. Mechanistic studies indicate that an in situ generated N-iodoaminium species serves as the key intermediate. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Akalezi, Chris O.; Oguzie, Emeka E. published 《Evaluation of anticorrosion properties of Chrysophyllum albidum leaves extract for mild steel protection in acidic media》.International Journal of Industrial Chemistry published the findings.Related Products of 78191-00-1 The information in the text is summarized as follows:

Background The inhibition efficiency of Chrysophyllum albidum extract in controlling corrosion of mild steel in 1 M HCl has been evaluated by weight loss, potentiodynamic polarization and electrochem. impedance techniques at 303 K. The effect of immersion time and temperature on inhibition efficiency of the extract was also studied. Results Inhibition was found to increase with increasing concentration of the extract but decrease with increasing time and temperature Data from electrochem. measurements suggest that the extract functioned by adsorption of the organic matter on the metal/corrodent interface, inhibiting both the anodic and cathodic half reactions of the corrosion process. The increase in concentration of the inhibitor causes an increase in the activation energy and a decrease in the exponential factor k. Conclusion The plant extracts follow Langmuir adsorption isotherm. Moreover, the process of adsorption is spontaneous, stable and considered to be phys. adsorption. The thermodn. properties recorded suggest that the process of film formation is higher than the destruction of the metal surface and that the adsorption process is exothermic.N-Methoxy-N-methylacetamide(cas: 78191-00-1Related Products of 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Trabbic, Christopher J.; George, Sage M.; Alexander, Evan M.; Du, Shengnan; Offenbacher, Jennifer M.; Crissman, Emily J.; Overmeyer, Jean H.; Maltese, William A.; Erhardt, Paul W. published 《Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: effects on potency and mode of activity》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 78191-00-1 The information in the text is summarized as follows:

A series of [(pyridinylcarbonyl)vinyl]indoles I [R1 = 4-MeO, 6-MeO, 7-MeO, 5,6-(MeO)2, R2 = H, R3 = Me; R1 = 6-MeO, R2 = H, R3 = CF3; R1 = 5-MeO, R2 = R3 = Me; R4 = 4-pyridinyl] as well as their aroylvinyl analogs I [R1 = 5-MeO; R2 = H; R3 = Me; R4 = 2,4,6-(MeO)3C6H2, 3,4,5-(MeO)3C6H2] with methoxy groups on the indole ring have been synthesized and evaluated for anticancer activity. The location of the methoxy group was shown to alter both the potency and mechanism of cell death. Remarkably, changing the methoxy from the 5-position to the 6-position switched the biol. activity from induction of methuosis to disruption of microtubules. The latter may represent a prototype for a new class of mitotic inhibitors with potential therapeutic utility. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 78191-00-1In 2021 ,《Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles》 appeared in Angewandte Chemie, International Edition. The author of the article were Desaintjean, Alexandre; Haupt, Tobias; Bole, Leonie J.; Judge, Neil R.; Hevia, Eva; Knochel, Paul. The article conveys some information:

Using the bimetallic combination sBu2Mg·2 LiOR (R = 2-ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo-arenes and -heteroarenes under mild reaction conditions and provides bromo-substituted magnesium reagents. Assessing the role of Lewis donor additives in these reactions revealed that N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDTA) finely tunes the regioselectivity of the Br/Mg exchange on dibromo-pyridines and quinolines. Combining spectroscopic with X-ray crystallog. studies, light has been shed on the mixed Li/Mg constitution of the organometallic intermediates accomplishing these transformations. These systems reacted effectively with a broad range of electrophiles, including allyl bromides, ketones, aldehydes, and Weinreb amides in good yields. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2019 ,《Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4》 was published in Angewandte Chemie, International Edition. The article was written by Gomez-Palomino, Alejandro; Cornella, Josep. The article contains the following contents:

Reported here is a simple and practical functionalization of primary sulfonamides, by a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention was focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1995,Journal of Chemical Research, Synopses included an article by Casadei, Maria Antonietta; Cesa, Stefania; Inesi, Achille; Moracci, Franco Micheletti. Application of 4746-61-6. The article was titled 《Electrochemical studies on haloamides. Part 11. Electrocarboxylation of carboxamides》. The information in the text is summarized as follows:

The electroreduction of C2-unsubstituted and C2-mono- and -di-substituted haloacetamides XCR1R2CONHR3 (X = Br, Cl, R1, R2 = H, Me, R3 = PhCH2, Ph), carried out in dipolar aprotic solvents and in the presence of CO2, yields synthetically used malonamates R4O2CCR1R2CONHR3 (R4 = Me, Bu) following in situ alkylation. In the experiment, the researchers used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application of 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Naccarato, Attilio; Tassone, Antonella; Martino, Maria; Elliani, Rosangela; Sprovieri, Francesca; Pirrone, Nicola; Tagarelli, Antonio published their research in Environmental Pollution (Oxford, United Kingdom) in 2021. The article was titled 《An innovative green protocol for the quantification of benzothiazoles, benzotriazoles and benzosulfonamides in PM10 using microwave-assisted extraction coupled with solid-phase microextraction gas chromatography tandem-mass spectrometry》.Computed Properties of C7H9NO2S The article contains the following contents:

Benzothiazoles (BTHs), benzotriazoles (BTRs), and benzenesulfonamides (BSAs) are chems. used in several industrial and household applications. Despite these compounds are emerging pollutants, there is still a lack of information about their presence in outdoor air samples. In this paper, we developed a new method for the quantification of BTHs, BTRs, and BSAs in airborne particulate matter (PM10). The extraction of fourteen analytes from PM10 was accomplished by microwave-assisted extraction (MAE) using an environmentally friendly mixture of water and ethanol. SPME was used to analyze the target compounds from the MAE extract by gas chromatog.-tandem mass spectrometry (SPME-GC-MS/MS), eliminating addnl. sample clean-up steps. The best working conditions for MAE and SPME were examined multivariately by exptl. design techniques. The target compounds were quantified in selected reaction monitoring acquisition mode. The proposed method was carefully validated, and the achieved results were satisfactory in terms of linearity, lower limit of quantification (picograms per cubic meter), intra- and inter-day accuracy (81-118% and 82-114%, resp.), and precision (repeatability and reproducibility in the range 2.3-17% and 7.4-19%, resp.). The application in a real monitoring campaign showed that the developed protocol is a valuable and eco-friendly alternative to the methods proposed so far. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2-BromoacetamideIn 2019 ,《Solid-phase synthesis of a novel phalloidin analog with on-bead and off-bead actin-binding activity》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Blanc, Antoine; Todorovic, Mihajlo; Perrin, David M.. The article contains the following contents:

Specific effectors of actin polymerization have found use as dynamic probes of cellular morphol. that may be used to gauge cellular response to stimuli and drugs. Of various natural products that target actin, phalloidin is one of the most potent and selective inhibitors of actin depolymerization Phalloidin and related members of the phallotoxin family are macrocyclic heptapeptides bearing a characteristic and rigidifying transannular tryptathionine bridge. Here we describe a solid-phase synthesis of a new phalloidin analog as a prototype for library development with the potential for on- and off-bead screening. To validate our method, we labeled the phalloidin derivative with a fluorescent dye which stained actin in CHO cells. Furthermore, a bioassay was developed allowing actin polymerization on beads carrying a phalloidin derivative In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics