Month: October 2022

Del Castillo-Santaella, Teresa; Hernandez-Morante, Juan Jose; Suarez-Olmos, Jesus; Maldonado-Valderrama, Julia; Pena-Garcia, Jorge; Martinez-Cortes, Carlos; Perez-Sanchez, Horacio published the artcile< Identification of the thistle milk component Silibinin(A) and Glutathione-disulphide as potential inhibitors of the pancreatic lipase: Potential implications on weight loss>, HPLC of Formula: 96829-58-2, the main research area is silibinin glutathione disulfide antiobesity agent obesity.

Peripheral targets like pancreatic-lipase appear to be the most suitable pharmacol. alternative for obesity, as with orlistat, although its adverse effects limit its use. Therefore, the aim of this work was to identify new natural compounds able to inhibit pancreatic-lipase in an in vitro model. The DrugBank database was used to perform docking calculations The best fitting-score compounds were further evaluated in vitro. Our data revealed that glutathione-disulfide (GSSG) and silibinin(A) inhibit pancreatic-lipase. This was confirmed by measuring hydrolysis in an emulsion model, obtaining that the suppression of lipid digestion by silibinin(A) was higher than that of GSSG and close to the effect of orlistat. Combined anal. established the existence of different inhibition mechanisms for each compound In summary, silibinin(A) and GSSG inhibited pancreatic-lipase and, therefore, may be served as promise natural compounds to face with obesity. Further studies comprise the next step to fully validate the suitability of these compounds

Journal of Functional Foods published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cheung, Fung Kei; Clarke, Adam J.; Clarkson, Guy J.; Fox, David J.; Graham, Mark A.; Lin, Changxue; Criville, Adriana Lorente; Wills, Martin published the artcile< Kinetic and structural studies on tethered' Ru(ii) arene ketone reduction catalysts>, Synthetic Route of 1192620-83-9, the main research area is kinetic structure tethered ruthenium arene ketone reduction catalyst.

A series of kinetic and structural investigations on ruthenium-based catalysts for asym. transfer hydrogenation (ATH) of ketones are reported. A method is reported for monitoring the formation of ruthenium hydride species in real time using 1H NMR spectroscopy.

Dalton Transactions published new progress about Crystal structure. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Synthetic Route of 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Natour, Abdul Kader; Rteil, Ali; Shepard, Alexander; Weaver, Mitchell; Nypaver, Timothy; Nemeh, Hassan; Tanaka, Daizo; Kabbani, Loay published the artcile< Outcomes of patients with acute type A aortic dissection and concomitant lower extremity malperfusion.>, HPLC of Formula: 96829-58-2, the main research area is ATAD; Acute limb ischemia; Acute type A aortic dissection; Malperfusion syndromes.

OBJECTIVE: The occurrence of acute lower limb ischemia (ALLI) is a serious risk within the context of aortic dissection repair. The aim of the present study was to examine the outcomes of patients with acute type A aortic dissection (ATAD) and concomitant lower extremity malperfusion. METHODS: We performed a retrospective medical record review at our tertiary referral center of patients who underwent ATAD repair from January 2002 to June 2018. We used univariate and multivariate analyses to compare the outcomes of patients with and without lower extremity malperfusion. The primary outcomes were 30-day and 1-year mortality. RESULTS: A total of 378 patients underwent ATAD repair during the study period. Their mean age was 57 years, 68% were men, and 51% were White. A total of 62 patients (16%) presented with concomitant ALLI, including 35 (9%) who presented with isolated ALLI and 27 (7%) who presented with ALLI and concomitant malperfusion of at least one other organ. Of the 62 patients with ALLI, 46 underwent only proximal aortic repair. Of the 378 patients, 6 died within the first 24 hours, and their limb perfusion was not assessed. Among the 40 patients who underwent isolated proximal repair and survived >24 hours, 34 (85%) had resolution of their ALLI. Of the 16 patients who underwent concomitant lower extremity peripheral vascular procedures, 10 had bypass procedures and 1 died within 24 hours due to refractory coagulopathy and hypotension. All six patients with adequate follow-up imaging studies had asymptomatic occlusion of the bypass graft with recanalization of the occluded native arteries. Patients who presented with any organ malperfusion had increased 30-day (odds ratio, 1.8; P = .04) and 1-year (odds ratio, 1.8; P = .04) mortality and decreased overall survival (P < .01). For the patients with isolated ALLI, no significant differences were found in 30-day or 1-year mortality or overall survival (P = .57). CONCLUSIONS: Proximal repair of ATAD resolves most cases of associated ALLI, and isolated ALLI does not affect short- or long-term survival. All patients with follow-up in our study who underwent extra-anatomic bypass developed asymptomatic graft occlusion, which could be attributed to competitive flow from the remodeled native arterial system. We believe that rapid and aggressive restoration of flow to the lower extremity is the best method to treat ALLI malperfusion syndrome. Close monitoring for the development of compartment syndrome is recommended. Journal of vascular surgery published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wei, Kajia; Cao, Xiaoxin; Gu, Wancong; Liang, Peng; Huang, Xia; Zhang, Xiaoyuan published the artcile< Ni-Induced C-Al2O3-Framework (NiCAF) Supported Core-Multishell Catalysts for Efficient Catalytic Ozonation: A Structure-to-Performance Study>, Reference of 6961-82-6, the main research area is nickel carbon aluminum framework catalytic ozonation wastewater treatment.

During catalytic ozonation, Al2O3-supported catalysts usually have stable structures but relatively low surface activity, while carbon-supported catalysts are opposite. To encourage their synergisms, we designed a Ni-induced C-Al2O2-framework (NiCAF) and reinforced it with a Cu-Co bimetal to create an efficient catalyst (CuCo/NiCAF) with a core-multishell structure. The partial graphitization of carbon adjacent to Ni crystals formed a strong out-shell on the catalyst surface. The rate constant for total organic carbon removal of CuCo/NiCAF (0.172 ± 0.018 min-1) was 67% and 310% higher than that of Al2O3-supported catalysts and Al2O3 alone, resp. The metals on CuCo/NiCAF contributed to surface-mediated reactions during catalytic ozonation, while the embedded carbon enhanced reactions within the solid-liquid boundary layer and in the bulk solution Moreover, carbon embedment provided a 76% increase in ·OH-production efficiency and an 86% increase in organic-adsorption capacity compared to Al2O3-supported catalysts. During the long-term treatment of coal-gasification wastewater (∼5 m3 day-1), the pilot-scale demonstration of CuCo/NiCAF-catalyzed ozonation revealed a 120% increase in ozone-utilization efficiency (ΔCOD/ΔO3 = 2.12) compared to that of pure ozonation (0.96). These findings highlight catalysts supported on NiCAF as a facile and efficient approach to achieve both high catalytic activity and excellent structural stability, demonstrating that they are highly viable for practical applications.

Environmental Science & Technology published new progress about Acids Role: PEP (Physical, Engineering or Chemical Process), POL (Pollutant), REM (Removal or Disposal), PROC (Process), OCCU (Occurrence). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Reference of 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Basson, Ashley J.; McLaughlin, Mark G. published the artcile< Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions>, Computed Properties of 1524-40-9, the main research area is calcium catalyst acyliminium ion hydroxyisoindolinone nucleophilic addition; isoindolinone preparation.

Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.

Journal of Organic Chemistry published new progress about Nucleophilic addition reaction. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Computed Properties of 1524-40-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Fengjuan; Song, Runjiang; Li, Shen; Shao, Xusheng published the artcile< In-Water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides>, Name: 2-Amino-4,5-dimethoxybenzamide, the main research area is quinazolinone preparation; dichloronitroethene cyclization anthranilamide water solvent.

An efficient synthetic methodol. was developed for direct formation of quinazolinones with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides. This strategy provides an alternative for quinazolinones construction with merits of proceeding in water, easy purification, and no addition of catalysts.

Synlett published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent) (2-amino). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Name: 2-Amino-4,5-dimethoxybenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stanetty, Peter; Krumpak, Barbara; Emerschitz, Thomas; Mereiter, Kurt published the artcile< Synthesis of benzo[d]-1,2-thiazole-1,1-dioxide derivatives via directed lithiation of 2,2-dimethyl-N-(phenylsulfonyl)-propanamides>, COA of Formula: C6H6FNO2S, the main research area is benzothiazole dioxide preparation; dimethylphenylsulfonylpropanamide lithiation cyclization electrophilic addition.

A novel synthesis of 7-substituted benz[d]-1,2-thiazole-1,1-dioxides I (R = H, CHO, CONHCMe3, CO2H, Me, OH, X = H, F, Cl) is presented including directed lithiation of 2,2-dimethyl-N-(phenylsulfonyl)-propanamides 3-XC6H4SO2NHCOCMe3, aryne-mediated cyclization and subsequent quenching of aryllithium intermediates with various electrophiles. A proposed mechanism is rationalized by some control experiments

Tetrahedron published new progress about 1524-40-9. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, COA of Formula: C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Appel, Rolf; Montenarh, Mathias published the artcile< Preparation of silylated amidosulfuric acid derivatives and their reaction with sulfur(IV) halides>, Synthetic Route of 25999-04-6, the main research area is aminosulfamide silylation; sulfamide silylation; sulfur halide sulfamide; diimide sulfur disulfamoyl; sulfinylamine thiobis.

The silylation of aminosulfamides, R2NSO2NH2 with HN(SiMe3)2 gave R2NSO2NHSiMe3 (R = Me, Et; R2N = piperidino, morpholino). Me2NSO2NHSiMe3 was lithiated and silylated with Me3SiCl to give Me3NSO2N(SiMe3)2 (I), also prepared from Me2NSO2NH2 and Me3SiCl. ROSO2NH2 [R = H (II), Me) was silylated with Me3SiCl to give ROSO2NR1SiMe3 (R = Me3Si, R1 = H; R = Me, R1 = Me3Si). II and Me3SiCl also gave Me3SiOSO2N(SiMe3)2 (III), also prepared from (Me3Si)3N and SO3. I and II with SOCl2 gave RSO2NSO [R = Me2N (IV), Me3SiO]. S(NSO)2 was prepared from [(Me3Si)2N]2SO2 and SOCl2, from Me3SiNSO and SO2Cl2, and from Me3SiN:S:NSiMe3 and SOCl2. IV was heated to give Me2NSO2N:S:NSO2NMe2, also prepared from I and SF4. I and SF4 also gave Me2NSO2N:SF2 (V), also prepared from IV and SF4. V and N(SiMe3)3 gave Me2NSO2N:S:NSiMe3.

Chemische Berichte published new progress about 25999-04-6. 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Synthetic Route of 25999-04-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guillory, Paulette; Kapoor, Ramesh N.; Pannell, Keith H.; Schulte, Louis; McKee, Steven D.; Zhang, Zhi-Yi; Bartsch, Richard C. published the artcile< High yield, one-pot syntheses of symmetrical diaryl-N,N-dialkyl carbamoylmethylphosphine oxide (CMPO) ligands>, Electric Literature of 5326-82-9, the main research area is carbamoylmethylphosphine diaryl preparation; Grignard reagent coupling reaction phosphite chloroacetamide.

A simple 1-pot high yield (∼70%) process is reported for the synthesis, in ∼100 g amounts, of sym. diaryl-N,N-di-i-butylcarbamoylphosphine oxide (CMPO) actinide extractants, aryl = 4-t-butylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl and 2,4,6-tri-i-propylphenyl.

Synthetic Communications published new progress about Coupling reaction. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Electric Literature of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Narasimhamurthy, Kereyagalahally H.; Chandrappa, Siddappa; Sharath Kumar, Kothanahally S.; Harsha, Kachigere B.; Ananda, Hanumappa; Rangappa, Kanchugarakoppal S. published the artcile< Easy access for the synthesis of 2-aryl 2,3-dihydroquinazolin-4(1H)-ones using gem-dibromomethylarenes as synthetic aldehyde equivalent>, Computed Properties of 112253-70-0, the main research area is quinazolinone dihydro aryl preparation.

One step synthesis of 2,3-dihydroquinazolin-4(1H)-ones I (R = H, Cl, OCH3; R1 = H, Br, Cl, OCH3; Ar = 3-ClC6H4, 4-pyridyl, 4-CF3C6H4, etc.) from gem-dibromomethylarenes ArCH(Br)2 using 2-aminobenzamide is described. Gem-dibromomethylarenes are used as aldehyde equivalent for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones, this synthesis takes shorter reaction time with quick isolation and excellent product yield.

RSC Advances published new progress about Amino amides Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Computed Properties of 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics