Month: October 2022

Vracko, M.; Stanojevic, M.; Sollner Dolenc, M. published an article in 2022, the title of the article was Comparison of predictions of developmental toxicity for compounds of solvent data set.Safety of N,N-Diethylacetamide And the article contains the following content:

We have considered a series of 235 compounds tech. classified as solvents. Chem., they belong to different classes. Their potential developmental toxicity was evaluated using two models available on platform VEGA HUB; model CAESAR and the Developmental/ Reproductive Toxicity library (PG) model. Models provide beside the prediction of developmental toxicity addnl. information on similar compounds from models training sets. In the report, first, we compare the predictions. Second, the sets of similar compounds have been used to implement the clustering scheme. The Kohonen artificial neural network method has been applied as a clustering method. The clusters obtained have been discussed for both models. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to developmental toxicity solvents data set artificial neural network, developmental toxicity, kohonen artificial neural network, vega hub caesar model, vega hub pg model, solvents and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VII. Structure-activity relations of sulfonamide carbonic anhydrase inhibitors. 2.Application of 97-09-6 And the article contains the following content:

Diuretic, natriuretic activities, and duration of the diuretic action in rats were studied with 22 sulfonamide derivatives To clarify the active form of the sulfonamides, the effect of pH of the rat body fluid on the diuretic activity was studied. The diuretic and natriuretic activities of the sulfonamides increased with an increase in their carbonic anhydrase inhibitory activity except for o-substituted benzenesulfonamides, disubstituted benzenesulfonamides, and 2-amino-1,3,4-thiadiazole-5-sulfonamide. A close relation between diuretic and natriuretic activities with the electronic characteristics of the sulfamoyl group, such as Hammett’s σ constant, pKa, NMR chem. shift of the sulfamoyl protons, and S:O valence-force constant was observed for the derivatives with some exceptions. A compound having a large partition coefficient and strong albumin binding ability showed long duration of the diuretic action. The diuretic and natriuretic activities of sulfonamides were enhanced by an increase in their dissociation constants The diuretic activity was enhanced under alkaline conditions. It was concluded that the active form of the sulfonamide carbonic anhydrase inhibitors was the ionized form. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to sulfonamides diuresis natriuresis, diuresis natriuresis sulfonamides, natriuresis sulfonamides diuresis, carbonic amhydrase drug, amhydrase carbonic drug, drug carbonic anhydrase and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2020, Rodriguez, Frederic; Saffon, Nathalie; Sammartino, Jose Camilla; Degiacomi, Giulia; Pasca, Maria Rosalia; Lherbet, Christian published an article.Safety of N-(3-Aminophenyl)acrylamide The title of the article was First triclosan-based macrocyclic inhibitors of InhA enzyme. And the article contained the following:

Two macrocyclic derivatives based on the triclosan frame were designed and synthesized as inhibitors of Mycobacterium tuberculosis InhA enzyme. One of the two mols. M02 displayed promising inhibitory activity against InhA enzyme with an IC50 of 4.7μM. Mol. docking studies of these two compounds were performed and confirmed that M02 was more efficient as inhibitor of InhA activity. These mols. are the first macrocyclic direct inhibitors of InhA enzyme able to bind into the substrate pocket. Furthermore, these biaryl ether compounds exhibited antitubercular activities comparable to that of triclosan against M. tuberculosis H37Rv strain. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Safety of N-(3-Aminophenyl)acrylamide

The Article related to preparation triclosan derivative macrocyclic inhibitor inha enzyme tuberculosis, enoyl-acp-reductase, inha, macrocycle, marchantin analogue, mycobacterium tuberculosis, triclosan and other aspects.Safety of N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2021, Liu, Yanhua; Chen, Yu; Feng, Mengjuan; Chen, Jianqiu; Shen, Weitao; Zhang, Shenghu published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Occurrence of antibiotics and antibiotic resistance genes and their correlations in river-type drinking water source, China. And the article contained the following:

The occurrence and distribution of antibiotics and antibiotic resistance genes (ARGs) in natural water has attracted worldwide attention. Antibiotic and ARG pollution in the surface water of drinking water sources might directly/indirectly affect human health. In this study, the distribution of 38 antibiotics, 10 ARGs, 2 integrons, and 16S r DNA in river-type water sources in a large city of China were monitored in winter, which was a period with high level of antibiotic pollution. The results showed that 20 antibiotics were detected with different detection frequencies. The antibiotic pollution in Dec. 2019 was relatively high, with the total concentrations of antibiotics ranging from 281.95 to 472.42 ng/L, followed by that in Jan. 2020 (191.70-337.29 ng/L) and Nov. 2019 (161.25-309.72 ng/L). Sulfacetamide was dominant in Nov. 2019 (23.52-219.00 ng/L) and in Jan. 2020 (113.18-209 ng/L), while norfloxacin in Dec. 2019 (146.72-290.20 ng/L). All the target antibiotics posed low or medium risk for aquatic organisms, and posed low health risk for mankind. Sul1 and erm36 were the predominant ARGs, and intI1 was the predominant integron in drinking water sources. Only tetA showed pos. correlations with its corresponding antibiotic (tetracycline). The rest of ARGs showed no correlations with antibiotics or pos. / neg. correlations with their non-corresponding antibiotics. Overall, the antibiotics and ARG pollution in these water sources was relatively low. These findings provided some reference data for the distribution of antibiotics and ARGs in river-type drinking water sources of large cities in China. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotics antibiotic resistance gene drinking water pollution china, antibiotic residues, antibiotic resistance genes, risk assessment, river-type drinking water, yangtze river and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wan, Yameng; Wu, Hao; Ma, Nana; Zhao, Jie; Zhang, Zhiguo; Gao, Wenjing; Zhang, Guisheng published an article in 2021, the title of the article was De novo design and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions.Related Products of 102-07-8 And the article contains the following content:

De novo design and synthesis of a series of 6H-dipyrido[1,2-e:2′,1′-i]purin-6-ones (DPs), e.g., I as a new class of visible-light photoredox catalysts (PCs) was described. The synthesized DPs showed their λAbs(max) values in 433-477 nm, excited state redox potentials E*1/2 red and E*1/2 ox in 1.15-0.69 eV and -1.41 to -1.77 eV (vs. SCE), resp. As a representative, DP I enabled productive guanylation of amines, including 1°, 2°, and 3°-alkyl primary amines, secondary amines, aryl and heteroaryl amines, amino-nitrile, amino acids and peptides as well as propynylamines and α-amino esters giving diversities in biol. important guanidines and cyclic guanidines. The photocatalytic efficacy of DP I in guanylation overmatched commonly used Ir and Ru polypyridyl complexes, and some organic PCs. Other salient merits of this method included broad substrate scope and functional group tolerance, gram-scale synthesis, and versatile late-stage derivatizations that led to a derivative 81 exhibiting 60-fold better anticancer activity against Ramos cells with IC50 of 0.086μM than that of clin. drug ibrutinib (5.1μM). The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to dipyridopurinone photocatalyst preparation dft, guanidine photochem preparation antiproliferative, amine thiourea guanylation dipyridopurinone photocatalyst visible light induced and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 2022, Chatterjee, Nabanita; Oliver, Clive L. published an article.Product Details of 685-91-6 The title of the article was Ligated Solvent Influence on Interpenetration and Carbon Dioxide and Water Sorption Hysteresis in a System of 2D Isoreticular MOFs. And the article contained the following:

Four two-dimensional (2D), fluorinated metal-organic frameworks (MOFs), [Cu(hfipbb)(DMF)]n·0.5(DMF)n (1), [Cu(hfipbb)(DEF)]n (2), [Cu3(hfipbb)3(DMA)3]n·6(DMA)n·2(H2O)n (3), and [Cu2(hfipbb)2(DEA)2]n·2(DEA)n·2(H2O)n (4), were synthesized where hfipbb = 4,4′-(hexafluoroisopropylidene)bis(benzoate), DMF = N,N’-DMF, DEF = N,N’-diethylformamide, DMA = N,N’-dimethylacetamide, and DEA = N,N’-diethylacetamide. The choice of a formamide or acetamide solvent ligand leads to 2-dimensional, doubly interpenetrated (1,2) or noninterpenetrated (3,4) MOF structures. Despite their lower potential void spaces, the doubly interpenetrated structures have superior CO2 and hydrogen sorption properties. Their 195 K CO2 sorption isotherms display inflection points, followed by 3̃-fold increases in sorption capacities and very large hysteretic behavior. Small changes in the identity of the ligated solvent ligand can affect whether the resulting MOF is interpenetrated or noninterpenetrated and so drastically affect the sorption properties. The activated phase of a 5th MOF, synthesized through DMF ligand exchange with H2O in 1 (1W), does not display an inflection point and subsequent increased CO2 sorption at 195 K, despite having the same degree of interpenetration, showing that even more subtle differences in the desolvated phases can lead to marked differences in their sorption behavior. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to copper fluoroisopropylidenebenzoate mof preparation sorption hysteresis gas adsorption, crystal structure copper fluoroisopropylidenebenzoate formamide acetamide isoreticular mof and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 29, 2021, Xiao, Shouchun; Lv, Shengchen; Cheng, Zheng; Hu, Caiwei; Li, Pengxi; Nan, Fang; Liu, Xueke; Liu, Donghui; Zhou, Zhiqiang; Wang, Peng published an article.COA of Formula: C13H12N2O The title of the article was A Simple Method for the Determination of Pharmaceutical and Personal Care Products in Fish Tissue Based on Matrix Solid-Phase Dispersion. And the article contained the following:

A simple and effective pretreatment method based on matrix solid-phase dispersion was developed for the determination of pharmaceutical and personal care products (PPCPs) and their metabolites in fish by high-performance liquid chromatog. tandem mass spectrometry. The type and amount of dispersant, adsorbent, and eluting solvent were optimized by a single-factor experiment and Box-Behnken design. Under the optimal conditions with 2.5 g of Florisil as a dispersant, 500 mg of C18 as an adsorbent, and 5 mL of acetonitrile as an eluting solvent, the recoveries ranged from 70.4 to 99.9% with relative standard deviations less than 10.5%, and the limits of quantitation ranged from 0.13 to 1.01μg/kg. The developed method was successfully applied to detect PPCPs in marketed fish, and five PPCPs, including triclocarban, sulfadiazine, sulfadimidine, sulfamethoxazole, and carbamazepine, were detected at trace levels. The proposed method, which has the advantages of short anal. time, less solvent consumption, and high sensitivity, can be used for the determination of trace PPCPs in fish. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to fish contamination pharmaceutical personal care product matrix solid dispersion, box−behnken design, fish, matrix solid-phase dispersion, pharmaceutical and personal care products and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boyle, Elizabeth Barksdale; Viet, Susan M.; Wright, David J.; Merrill, Lori S.; Alwis, K. Udeni; Blount, Benjamin C.; Mortensen, Mary E.; Moye, John Jr.; Dellarco, Michael published an article in 2016, the title of the article was Assessment of exposure to VOCs among pregnant women in the National Children’s study.Computed Properties of 27115-50-0 And the article contains the following content:

Epidemiol. studies can measure exposure to volatile organic compounds (VOCs) using environmental samples, biomarkers, questionnaires, or observations. These different exposure assessment approaches each have advantages and disadvantages; thus, evaluating relationships is an important consideration. In the National Children’s Vanguard Study from 2009 to 2010, participants completed questionnaires and data collectors observed VOC exposure sources and collected urine samples from 488 third trimester pregnant women at in-person study visits. From urine, we simultaneously quantified 28 VOC metabolites of exposure to acrolein, acrylamide, acrylonitrile, benzene, 1-bromopropane, 1,3-butadiene, carbon disulfide, crotonaldehyde, cyanide, N,N-dimethylformamide, ethylbenzene, ethylene oxide, propylene oxide, styrene, tetrachloroethylene, toluene, trichloroethylene, vinyl chloride, and xylene exposures using ultra high performance liquid chromatog. coupled with an electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS) method. Urinary thiocyanate was measured using an ion chromatog. coupled with an electrospray ionization tandem mass spectrometry method (IC-ESI/MSMS). We modeled the relationship between urinary VOC metabolite concentrations and sources of VOC exposure. Sources of exposure were assessed by participant report via questionnaire (use of air fresheners, aerosols, paint or varnish, organic solvents, and passive/active smoking) and by observations by a trained data collector (presence of scented products in homes). We found several significant (p < 0.01) relationships between the urinary metabolites of VOCs and sources of VOC exposure. Smoking was pos. associated with metabolites of the tobacco constituents acrolein, acrylamide, acrylonitrile, 1,3-butadiene, crotonaldehyde, cyanide, ethylene oxide, N,N-dimethylformamide, propylene oxide, styrene, and xylene. Study location was neg. associated with the toluene metabolite N-acetyl-S-(benzyl)-L-cysteine (BMA), and paint use was pos. associated with the xylene metabolites 2-methylhippuric acid (2MHA) and 3-Methylhippuric acid & 4-methylhippuric acid (3MHA + 4MHA). A near-significant (p = 0.06) relationship was observed between acrylamide metabolites and observation of incense. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Computed Properties of 27115-50-0

The Article related to environmental exposure volatile organic compound pregnancy, national children’s study, birth cohort study, pregnant women, tobacco, urinary metabolites, volatile organic compounds and other aspects.Computed Properties of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 1, 2021, Guo, Ruonan; Li, Yunhe; Chen, Ying; Liu, Yu; Niu, Bihui; Gou, Jianfeng; Cheng, Xiuwen published an article.Recommanded Product: 144-80-9 The title of the article was Efficient degradation of sulfamethoxazole by CoCu LDH composite membrane activating peroxymonosulfate with decreased metal ion leaching. And the article contained the following:

In this study, we prepared two types of composite membranes decorated with CoCu layered double hydroxide (LDH) nanoparticles, i.e. LDH@Calotropis gigantean fiber (LDH@CGF) and LDH@polyvinylidene fluoride (LDH@PVDF) for the first time. Besides, the application potential of different types of composite functional membranes based on LDH in PMS activation system was compared. Both of the LDH-based composite membranes exhibited excellent activity in peroxymonosulfate (PMS) activation process. More importantly, the composite membrane could be separated from the treated water to meet the need of practical application. The superior composite membrane was identified as LDH@PVDF, which was with excellent PMS activation capability and pretty lower metal ions leaching concentration (cobalt 0.044 mg L-1, copper 0.026 mg L-1). And then, LDH@PVDF was employed to investigate the PMS activation performance in various pharmaceutical pollutants removal processes. Besides, the activity of LDH@PVDF for SMX degradation in real aquatic environment (tap water and wastewater) was detected, proving the wide practical applicability of LDH@PVDF membrane. Finally, the possible SMX degradation pathway and PMS activation mechanism occurring in LDH-based composite membrane/PMS system were proposed. Hence, this study for LDH-based membranes construction may provide new insights into the environmentally-friendly catalytic membranes preparation and practical application in wastewater treatment. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Recommanded Product: 144-80-9

The Article related to sulfamethoxazole degradation cobalt copper layered double hydroxide composite membrane, composite membrane peroxymonosulfate metal ion leaching pharmaceutical wastewater treatment and other aspects.Recommanded Product: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2020, Konkle, Stacey L.; Zierold, Kristina M.; Taylor, Kira C.; Riggs, Daniel W.; Bhatnagar, Aruni published an article.Reference of 2-(4-Methylbenzamido)acetic acid The title of the article was National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. And the article contained the following:

Exposure to air pollution is a leading cause of global mortality. Volatile organic compounds (VOCs) are constituents of ambient air that could exert adverse health effects. To examine the relationship between VOC levels in ambient air and individual-level exposure to VOCs, as assessed by urinary VOC metabolites. Secular trends in 11 ambient air VOCs (2005-2013) and individual-level metabolites of 14 VOCs (2005-2014) were assessed using National Monitoring Programs (NMP) and National Health and Nutrition Examination Survey (NHANES) data, resp. To isolate environmental exposure, individuals reporting exposure to tobacco smoke were excluded. Quantile regression models were used to assess secular trends in VOC exposure, and survey-weighted regression models were built to identify factors associated with VOC exposure. All annual levels of ambient VOCs decreased from 2005 to 2013 (Range: 12.5%-77.2%). However, 11 of the corresponding VOC metabolites increased during the same time (Range: 0.3%-53.6%). There was a proportional change in patterns of VOC exposure across NHANES waves, with the middle quantiles of exposure showing the largest increase. VOC exposures were significantly associated with age, sex, race, education, and phys. inactivity, but not with secular VOC trends. In the United States, individual-level exposure to several VOCs increased between 2005 and 2014 despite a decline in ambient air VOC levels. This inverse relationship suggests that ambient VOCs are not the primary source of VOC exposure, therefore, decreasing ambient VOCs alone may not be sufficient to protect against the adverse health effects associated with VOC exposure. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Reference of 2-(4-Methylbenzamido)acetic acid

The Article related to ambient air volatile organic compound biomarker united states, air pollution, biomarkers of exposure, environmental health, nhanes, secular trends, vocs, volatile organic compounds and other aspects.Reference of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics