Month: October 2022

On July 31, 2021, Yadav, Mangal S.; Singh, Sumt K.; Agrahari, Anand K.; Singh, Anoop S.; Tiwari, Vinod K. published an article.Reference of 1,3-Diphenylurea The title of the article was N -Acylbenzotriazoles as Proficient Substrates for an Easy Access to Ureas, Acylureas, Carbamates, and Thiocarbamates via Curtius Rearrangement Using Diphenylphosphoryl Azide (DPPA) as Azide Donor. And the article contained the following:

A diverse range of ureas RNHC(O)NHC(O)R1 [R = Ph, 2-IC6H4, 3-BrC6H4, etc.; R1 = Ph, 2-IC6H4], N-acylureas R1NHC(O)NHR2 [R1 = Ph, 3-BrC6H4, 2-MeOC6H4, etc; R2 = Ph, 2-BrC6H4, 2-IC6H4], carbamates and thiocarbamates R1NHC(O)R2 [R1 = Ph, 3,5-di-MeC6H3, 3-MeC6H4; R2 = OPh, SPh, S(2-MeC6H4), etc.] was synthesized in good to excellent yields by reacting N-acylbenzotriazoles individually with amines/amides/phenols/thiols in the presence of diphenylphosphoryl azide (DPPA) as a suitable azide donor in anhydrous toluene at 110°C for 3-4 h. In this route, DPPA was found to be a good alternative to trimethylsilyl azide and sodium azide for the azide donor in Curtius degradation The high reaction yields, one-pot and metal-free conditions, straightforward nature, easy handling, use of readily available reagents and in many cases avoidance of column chromatog. were the notable features of the devised protocol. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea

The Article related to urea or acylurea preparation, acylbenzotriazole amine or amide curtius rearrangement dppa, carbamate or thiocarbamate preparation, phenol or thiol acylbenzotriazole curtius rearrangement dppa and other aspects.Reference of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2013, Mange, Yatin J.; Isloor, Arun M.; Malladi, Shridhar; Isloor, Shrikrishna; Fun, Hoong-Kun published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives. And the article contained the following:

In the present investigation, a series of new Schiff bases were synthesized by the condensation of N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides with various substituted aromatic aldehydes in ethanol-dioxane mixture using catalytic amount of sulfuric acid. The starting materials N-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-4-H/Me-benzamides were in turn synthesized by the fusion of (4-H/Me-benzoyl)-glycines with thiocarbohydrazide. Newly synthesized compounds were characterized by IR, NMR, mass spectra and elemental analyses. All the compounds were evaluated for their antibacterial and antifungal activity using the Min. Inhibition Concentration (MIC) method by serial dilution technique. Few of the compounds were found to be biol. active. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to thiocarbohydrazide aroylglycine cyclocondensation, aminomercaptotriazole arylamidomethyl preparation condensation aryl aldehyde, schiff base triazolethiol preparation antibacterial antifungal and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gogoi, Bhaskarjyoti; Gogoi, Dhrubajyoti; Gogoi, Neelutpal; Mahanta, Saurov; Buragohain, Alak K. published an article in 2022, the title of the article was Network pharmacology based high throughput screening for identification of multi targeted anti-diabetic compound from traditionally used plants.Category: amides-buliding-blocks And the article contains the following content:

The incurable Type 2 diabetes mellitus (T2DM) has now been considered a pandemic with only supportive care in existence. Due to the adverse effects of available anti-diabetic drugs, there arises a great urgency to develop new drug mols. One of the alternatives that can be considered for the treatment of T2DM are natural compounds from traditionally used herbal medicine. The present study undertakes, an integrated multidisciplinary concept of Network Pharmacol. to evaluate the efficacy of potent anti-diabetic compound from traditionally used anti-diabetic plants of north east India and followed by DFT anal. In the course of the study, 22 plant species were selected on the basis of their use in traditional medicine for the treatment of T2DM by various ethnic groups of the north eastern region of India. Initially, a library of 1053 compounds derived from these plants was generated. This was followed by network preparation between compounds and targets based on the docking result. The compounds having the best network property were considered for DFT anal. We have identified that auraptene, a monoterpene coumarin for its activity in the management of Type 2 diabetes mellitus and deciphered its unexplored probable mechanisms. Mol. dynamics simulation of the ligand-protein complexes also reveals the stable binding of auraptene with the target proteins namely, Protein Kinase C θ, Glucocorticoid receptor, 11-β hydroxysteroid dehydrogenase 1 and Aldose Reductase, all of which form uniform interactions throughout the MD simulation trajectory. Therefore, this finding could provide new insights for the development of a new anti-diabetic drug. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to traditional plant antidiabetic compound high throughput screening network pharmacol, type 2 diabetes mellitus, insulin resistance, natural products, network pharmacology, traditional knowledge and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 1, 2022, Han, Yu; Hu, Li-Xin; Liu, Ting; Liu, Jing; Wang, Yu-Qing; Zhao, Jia-Hui; Liu, You-Sheng; Zhao, Jian-Liang; Ying, Guang-Guo published an article.Application of 144-80-9 The title of the article was Non-target, suspect and target screening of chemicals of emerging concern in landfill leachates and groundwater in Guangzhou, South China. And the article contained the following:

Landfill sites have been regarded as a significant source of chems. of emerging concern (CECs) in groundwater. However, our understanding about the compositions of CECs in landfill leachate and adjacent groundwater is still very limited. Here we investigated the CECs in landfill leachates and groundwater of Guangzhou in South China by target, suspect and non-target anal. using high-resolution mass spectrometry (HRMS). A variety of CECs (n = 242), including pharmaceuticals (n = 64), pharmaceutical intermediates (n = 18), personal care products (n = 9), food additives (n = 18), industrial chems. (n = 82, e.g., flame retardants, plasticizers, antioxidants and catalysts), pesticides (n = 26), transformation products (n = 8) and other organic compounds (n = 17) were (tentatively) identified by non-target and suspect screening. 142 CECs were quantitated with target anal., and among them 37, 24 and 27 CECs were detected resp. in the raw leachate (272-1780μg/L), treated leachate (0.25-0.81μg/L) and groundwater (0.10-53.7μg/L). The CECs in the raw leachates were efficiently removed with the removal efficiencies greater than 88.7%. Acesulfame, bisphenol F and ketoprofen were the most abundant compounds in both treated leachate and groundwater. The CECs in groundwater was found most likely to be originated from the landfill sites. Our results highlight the importance of non-target screening in identifying CECs, and reveal the contamination risk of groundwater by landfill leachate. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to chem target screening landfill leachates groundwater guangzhou south china, chemicals of emerging concern, groundwater, high-resolution mass spectrometry, landfill leachate, non-target analysis and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Li; Schug, Kevin A. published an article in 2014, the title of the article was Continuous-flow extractive desorption electrospray ionization coupled to normal phase separations and for direct lipid analysis from cell extracts.Computed Properties of 5455-98-1 And the article contains the following content:

Normal phase liquid chromatog. is a common mode for chiral separations Many chiral amines are used as drugs or are important intermediates for drug synthesis. Electrospray ionization mass spectrometry is well known for its high sensitivity. However, when using normal phase liquid chromatog., electrospray ionization is hampered by the poor ionization efficiency of analytes from organic eluents. Continuous-flow extractive desorption electrospray ionization, which introduces the eluents through a hypodermic needle into the electrospray plume is demonstrated here for its success to interface normal phase liquid chromatog. to mass spectrometry detection. Such an approach was shown to be as or more sensitive than UV detection for a selected set of aromatic amine-functionalized enantiomers. Also demonstrated is the direct infusion of cell extracts to monitor phospholipids from three different bacterial cells. Despite their presence in non-electrospray-ionization-friendly extraction solvents, continuous-flow extractive desorption electrospray ionization enabled the sensitive detection of phospholipids and the ability to tune ion forms through incorporation of different spray modifiers. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to extractive desorption electrospray mass spectrometry lipid cell, liquid chromatog bacteria phospholipid, ambient ionization, chiral separation, direct analysis, mass spectrometry, phospholipids and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 13, 2016, Ferguson, Fleur M.; Ni, Jing; Zhang, Tinghu; Tesar, Bethany; Sim, Taebo; Kim, Nam Doo; Deng, Xianming; Brown, Jennifer R.; Zhao, Jean J.; Gray, Nathanael S. published an article.COA of Formula: C9H10N2O The title of the article was Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors. And the article contained the following:

Dual inhibition of PI3K-δ and PI3K-γ is an established therapeutic strategy for treatment of hematol. malignancies. Reported mols. targeting PI3K-δ/γ selectively are chem. similar and based upon isoquinolin-1(2H)-one or quinazolin-4(3H)-one scaffolds. Here we report a chem. distinct series of potent, selective PI3K-δ/γ inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold with comparable biochem. potency and cellular effects on PI3K signaling. We envisage these mols. will provide useful leads for development of next-generation PI3K-δ/γ targeting therapeutics. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).COA of Formula: C9H10N2O

The Article related to pi3k delta gamma inhibitor benzopyrimidodiazepinone preparation structure activity kinome, pi3k-γ, pi3k-δ, kinase inhibitor, p110-γ, p110-δ, phosphatidylinositol-4,5-bisphosphate 3-kinase-delta and other aspects.COA of Formula: C9H10N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 20, 2021, Zhang, Lili; Zhang, Cheng; Lian, Keting; Ke, Dongfang; Xie, Ting; Liu, Chongxuan published an article.Synthetic Route of 144-80-9 The title of the article was River restoration changes distributions of antibiotics, antibiotic resistance genes, and microbial community. And the article contained the following:

Although river restoration has been increasingly implemented to restore water quality in ecosystems, its effect on the removal of emerging pollutant antibiotics, and their resultant influence on microbial community structure and functions in river water is still unclear. This study investigated the changes of antibiotics, antibiotic resistant genes (ARGs), microbial communities, and their spatial distributions in a megacity river before and after river restoration. Results indicated that although the restoration activities including riverbed dredging, riverbank hardening, sewage and storm water separation and re-pipelining improved water quality such as by decreasing total phosphorus (TP) content from 4.60 mg/L in 2018 to 0.98 mg/L in 2020, the antibiotic concentrations in river water increased. Total antibiotic concentrations in the water samples were higher in 2020 (506.89-6952.50 ng/L) than those in 2018 (137.93-1751.51 ng/L), likely caused by increased usage of antibiotics in 2020 for COVID-19 treatment. The spatial distributions of antibiotics were less varied likely as a result of less retardation and fast mixing during antibiotic transport. The result also found that the abundance of Actinobacteria and Proteobacteria, and their correlations with ARGs increased. The spatial distributions of ARGs and microbial communities became less varied in the river water, consistent with the antibiotic variations before and after river restoration. Physicochem. changes such as decreased TP and dissolved organic carbon content may also be a factor. The results indicated that the current river restoration efforts were not effective in removing antibiotics, and implied that further studies are needed to investigate their subsequent transformation and transport, and to assess their risks to the health of ecosystems. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to antibiotic resistance gene microorganism maozhou river restoration, antibiotic resistance genes, antibiotics, maozhou river, river contamination, river restoration, riverine microbial community and other aspects.Synthetic Route of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mut, Ludmila; Grobosch, Thomas; Binscheck-Domass, Torsten; Frenzel, Wolfgang published an article in 2016, the title of the article was Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of acidic and neutral drugs.Category: amides-buliding-blocks And the article contains the following content:

A multi-analyte screening method for the quantification of 50 acidic/neutral drugs in human plasma based on online solid-phase extraction (SPE)-HPLC with photodiode array detection (DAD) was developed, validated and applied for clin. investigation. Acetone and methanol for protein precipitation, three different SPE materials (two electro-neutral, one strong anion-exchange, one weak cation-exchange) for online extraction, five HPLC-columns [one C18 (GeminiNX), two phenyl-hexyl (Gemini C6-Ph, Kinetex Phenyl-Hexyl) and two pentafluorophenyl (LunaPFP(2), KinetexPFP)] for anal. separation were tested. For sample pre-treatment, acetone in the ratio 1:2 (plasma:acetone) showed a better baseline and fewer matrix peaks in the chromatogram than methanol. Only the strong anion-exchanger SPE cartridge (StrataX-A, pH 6) allowed the extraction of salicylic acid. Anal. separation was carried out on a Gemini C6-Ph column (150 × 4.6 mm, 3 μm) using gradient elution with acetonitrile-water 90:10 (volume/volume) and phosphate buffer (pH 2.3). Linear calibration curves with correlation coefficients r ≥ 0.9950/0.9910 were obtained for 46/four analytes. Addnl., this method allows the quantification of 23 analytes for therapeutic drug monitoring. Limits of quantitation ranged from 0.1 (amobarbital) to 23 mg/L (salicylic acid). Inter-/intra-day precisions of quality control samples (low/high) were better than 13% and accuracy (bias) ranged from -14 to 10%. A computer-assisted database was created for automated detection of 223 analytes of toxicol. interests. Four cases of multi-drug intoxications are presented. Copyright © 2015 John Wiley & Sons, Ltd. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks

The Article related to drug toxicol screening human plasma spe hplc dad, acidic and neutral drugs, multi-analyte screening, on-line solid-phase extraction, plasma samples, systematic toxicological analysis, validation and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 10, 2022, Xu, Xiaolei; Gujarati, Priyansh D.; Okwor, Neechi; Sivey, John D.; Reber, Keith P.; Xu, Wenqing published an article.Reference of 2-Chloroacetamide The title of the article was Reactivity of chloroacetamides toward sulfide + black carbon: Insights from structural analogues and dynamic NMR spectroscopy. And the article contained the following:

Chloroacetamides are commonly used in herbicide formulations, and their occurrence has been reported in soils and groundwater. However, how their chem. structures affect transformation kinetics and pathways in the presence of environmental reagents such as hydrogen sulfide species and black carbon has not been investigated. In this work, we assessed the impact of increasing Cl substituents on reaction kinetics and pathways of six chloroacetamides. The contribution of individual pathways (reductive dechlorination vs. nucleophilic substitution) to the overall decay of selected chloroacetamides was differentiated using various exptl. setups; both the transformation rates and product distributions were characterized. Our results suggest that the number of Cl substituents affected reaction pathways and kinetics: trichloroacetamides predominantly underwent reductive dechlorination whereas mono- and dichloroacetamides transformed via nucleophilic substitution. Furthermore, we synthesized eight dichloroacetamide analogs (Cl2CHC(=O)NRR′) with differing R groups and characterized their transformation kinetics. Dynamic NMR spectroscopy was employed to quantify the rotational energy barriers of dichloroacetamides. Our results suggest that adsorption of dichloroacetamides on black carbon constrained R groups from approaching the dichloromethyl carbon and subsequently favored nucleophilic attack. This study provides new insights to better predict the fate of chloroacetamides in subsurface environments by linking their structural characteristics to transformation kinetics and pathways. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to black carbon chloroacetamide transformation kinetics structural analog dynamic nmr, dechlorination, dynamic nmr spectroscopy, halogenated agrochemical fate, polysulfides, subsurface environments and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2022, Han, Lingxi; Liu, Tong; Fang, Kuan; Li, Xianxu; You, Xiangwei; Li, Yiqiang; Wang, Xiuguo; Wang, Jun published an article.Electric Literature of 79-07-2 The title of the article was Indigenous functional microbial communities for the preferential degradation of chloroacetamide herbicide S-enantiomers in soil. And the article contained the following:

This study investigated indigenous functional microbial communities associated with the degradation of chloroacetamide herbicides acetochlor (ACE), S-metolachlor (S-MET) and their enantiomers in repeatedly treated soils. The results showed that biodegradation was the main process for the degradation of ACE, S-MET and their enantiomers. Eight dominant bacterial genera associated with the degradation were found: Amycolatopsis, Saccharomonospora, Mycoplasma, Myroides, Mycobacterium, Burkholderia, Afipia, and Kribbella. The S-enantiomers of ACE and S-MET were preferentially degraded, which mainly relied on Amycolatopsis, Saccharomonospora and Kribbella for the ACE S-enantiomer and Amycolatopsis and Saccharomonospora for the S-MET S-enantiomer. Importantly, the relative abundances of Amycolatopsis and Saccharomonospora increased by 146.3%-4467.2% in the S-enantiomer treatments of ACE and S-MET compared with the control, which were significantly higher than that in the corresponding R-enantiomer treatments (25.3%-4168.2%). Both metagenomic and qPCR analyses demonstrated that four genes, ppah, alkb, benA, and P 450, were the dominant biodegradation genes (BDGs) potentially involved in the preferential degradation of the S-enantiomers of ACE and S-MET. Furthermore, network anal. suggested that Amycolatopsis, Saccharomonospora, Mycoplasma, Myroides, and Mycobacterium were the potential hosts of these four BDGs. Our findings indicated that Amycolatopsis and Saccharomonospora might play pivotal roles in the preferential degradation of the S-enantiomers of ACE and S-MET. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Electric Literature of 79-07-2

The Article related to chloroacetamide enantiomer microbial community biodegradation wastewater treatment china, chloroacetamide herbicides, degradation, enantiomers, functional microbial communities, network analysis and other aspects.Electric Literature of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics