Month: October 2022

On June 1, 2022, Sai Kumar, Gobbilla; Bhattacharjee, Jayeeta; Kumari, Kusum; Moorthy, Shruti; Bandyopadhyay, Ayan; Kumar Singh, Saurabh; Panda, Tarun K. published an article.Category: amides-buliding-blocks The title of the article was Hydroboration of nitriles, esters, and amides catalyzed by simple neosilyllithium. And the article contained the following:

We present here an efficient method for the hydroboration of organic nitriles, carboxylic esters, and carboxamides with pinacolborane (HBpin) using an alkali metal catalyst, neosilyllithium (LiCH2SiMe3), in neat reaction conditions. The reactions were accomplished with efficient catalytic reactivity and demonstrated by neosilyllithium at room temperature, in solvent-free condition, to afford a high yield of the corresponding N-boryl amines, boryl ethers, and amine hydrochlorides. The protocol for the catalytic reaction presented in this paper is simple and efficient, with diverse substrate scope for nitriles, carboxylic esters, and carboxamides showing excellent functional group tolerance. DLPNO-CCSD(T) calculations were also performed, showing that the hydroboration of nitriles catalyzed by neosilyllithium occurs through the pre-coordination of the nitrile at Lewis acid lithium followed by hydride migration from the B-H entity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks

The Article related to hydroboration nitrile ester amide preparation aralkyl amine alc, lithium organometallic catalyst hydroboration reduction nitrile ester amide, crystal mol optimized structure picolyl diborylamine and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2021, Zhao, Wentao; Jiang, Rui; Guo, Wenping; Guo, Chao; Li, Shilei; Wang, Juanqiang; Wang, Shouwei; Li, Yingying published an article.Product Details of 144-80-9 The title of the article was Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS. And the article contained the following:

A rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-lipophile balance) solid-phase extraction cartridge. Data were collected using ultra-high-performance liquid chromatog. coupled to Quadrupole-Exactive Orbitrap mass spectrometry. The limits of detection of 155 veterinary drugs ranged from 0.1μg/kg to 10μg/kg. The recovery rates were between 79.2 and 118.5% in all matrixes studied, with relative standard deviation values less than 15% (n = 6). The evaluated method allows the reliable screening, quantification, and identification of 155 veterinary drug residues in animal source food and has been successfully applied in authentic samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to veterinary drug residue animal source food uplcqexactive orbitrap ms, animal source foods, qualitative screening, quantitative determination, uplc-q-exactive orbitrap/ms, veterinary drug residues and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 1, 2021, Chiu, Chun-Hui; Chen, Chi-Tsung; Cheng, Ming-Huei; Pao, Li-Heng; Wang, Chi; Wan, Gwo-Hwa published an article.Electric Literature of 27115-50-0 The title of the article was Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel. And the article contained the following:

Toluene and xylene are common components of surgical smoke, whereas hippuric acid (HA) and methylhippuric acid (MHA) are the products of toluene and xylene metabolism in humans, resp. HA and MHA can be used as indicators to evaluate the exposure hazards of toluene and xylene. In this study, we used liquid chromatog. tandem mass spectrometry (LC-MS/MS) to simultaneously analyze the HA, o-/m-/p-MHA, and creatinine contents in the urine of healthcare personnel. Concentrations of HA and o-/m-/p-MHAs were normalized to those of creatinine and used to analyze urine samples of 160 operating room (OR) healthcare personnel, including administrative staff, surgical nurses, nurse anesthetists, and surgeons. The results showed that the five analytes could be accurately separated and exhibited good linearity (r > 0.9992). The rate of recovery was between 86% and 106%, and the relative standard deviation was less than 5%. Urine from administrative staff presented the highest median concentration of hippuric acid (0.25 g/g creatinine); this was significantly higher than that found in the urine of surgeons (0.15 g/g). The concentrations of urinary o-/m-/p-MHAs in surgical nurses were higher than those in administrative staff, nurse anesthetists, and surgeons. Furthermore, the type, sex, and age of healthcare personnel were associated with changes in urine HA and o-/m-/p-MHA concentrations Healthcare personnel should be aware of the risk of exposure to surgical smoke. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to methyl hippuric acid surgical smoke occupational health hazard, high-performance liquid chromatography tandem mass spectrometry, hippuric acid, methylhippuric acid, operating room, surgical smoke and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 28, 2017, Liu, He; Qu, Menghua; Xu, Lina; Han, Xu; Wang, Changyuan; Shu, Xiaohong; Yao, Jihong; Liu, Kexin; Peng, Jinyong; Li, Yanxia; Ma, Xiaodong published an article.Product Details of 16230-24-3 The title of the article was Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton’s tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia. And the article contained the following:

A new series of diphenylpyrimidine derivatives (SFA-DPPYs) were synthesized by introducing a functional sulfonamide into the C-2 aniline moiety of pyrimidine template, and then were biol. evaluated as potent Bruton’s tyrosine kinase (BTK) inhibitors. Among these mols., inhibitors 10c, 10i, 10j and 10k (I – IV, resp.) displayed high potency against the BTK enzyme, with IC50 values of 1.18 nM, 0.92 nM, 0.42 nM and 1.05 nM, resp. In particular, compound 10c could remarkably inhibit the proliferation of the B lymphoma cell lines at concentrations of 6.49 μM (Ramos cells) and 13.2 μM (Raji cells), and was stronger than the novel agent spebrutinib. In addition, the inhibitory potency toward the normal PBMC cells showed that inhibitor 10c possesses low cell cytotoxicity. All these explorations indicated that mol. 10c could serve as a valuable inhibitor for B-cell lymphoblastic leukemia treatment. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Product Details of 16230-24-3

The Article related to sulfonamide phenylpyrimidine bruton tyrosine kinase inhibitor lymphoblastic leukemia, b cell lymphoblastic leukemia sulfonamide phenylpyrimidine, btk, inhibitor, leukemia, pyrimidine, sulfonamide and other aspects.Product Details of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 1, 2021, Lu, Xiaogang; Zhang, Zixuan; Liu, Haibo; Tang, Hui; Gao, Runli; Pei, Chengxin; Wang, Hongmei; Xiao, Junhua published an article.Product Details of 685-91-6 The title of the article was Forensic signatures of a chemical weapon precursor DMPADC for determination of a synthetic route. And the article contained the following:

Chem. forensics has been widely recognized as an important tool to investigate alleged use of chem. weapons and/or to identify the illicit production of chem. warfare agents. This paper describes the use of gas chromatog. and mass spectrometry (GC-MS) to determine chem. attribution signatures (CAS) N,N-dimethylphosphoramidic dichloride (DMPADC), a key precursor of tabun, for tracking the production of tabun. Synthetic samples were identified and classified by using GC-MS and chemometrics. Anal. samples (n = 27) were collected from three synthetic DMPADC routes; 20 potential CAS were identified, and the structures of five CAS were assigned. Principal component anal. (PCA) was performed to summarize the distribution trend of the samples and to check for the presence of outliers. A Partial least squares discriminant anal. (PLSDA) model was established to discriminate and classify the synthetic samples. The proposed model in this paper has high predictive ability, and the test set samples can be correctly categorized. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to dimethylphosphoramidic dichloride forensic analysis gas chromatog mass spectrometry, chemical attribution signatures, chemical forensics, chemometrics, n,n-dimethylphosphoramidic dichloride, tabun and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

De Jesus, Victor R.; Bhandari, Deepak; Zhang, Luyu; Reese, Christopher; Capella, Kimberly; Tevis, Denise; Zhu, Wanzhe; Del Valle-Pinero, Arseima Y.; Lagaud, Guy; Chang, Joanne T.; van Bemmel, Dana; Kimmel, Heather L.; Sharma, Eva; Goniewicz, Maciej L.; Hyland, Andrew; Blount, Benjamin C. published an article in 2020, the title of the article was Urinary biomarkers of exposure to volatile organic compounds from the population assessment of tobacco and health study wave 1 (2013-2014).Related Products of 27115-50-0 And the article contains the following content:

Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013-2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to volatile oragnic compound metabolite biomarker tobacco smoke adult population, path study, e-cigarette users, smokeless tobacco users, tobacco smoke exposure, volatile organic compound metabolites and other aspects.Related Products of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 30, 2021, Tevis, Denise S.; Flores, Sharon R.; Kenwood, Brandon M.; Bhandari, Deepak; Jacob, Peyton 3rd; Liu, Jia; Lorkiewicz, Pawel K.; Conklin, Daniel J.; Hecht, Stephen S.; Goniewicz, Maciej L.; Blount, Benjamin C.; De Jesus, Victor R. published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system. And the article contained the following:

Increased interest in volatile organic compound (VOC) exposure has led to an increased need for consistent, systematic, and informative naming of VOC metabolites. As anal. methods have expanded to include many metabolites in a single assay, the number of acronyms in use for a single metabolite has expanded in an unplanned and inconsistent manner due to a lack of guidance or group consensus. Even though the measurement of VOC metabolites is a well-established means to investigate exposure to VOCs, a formal attempt to harmonize acronyms amongst investigators has not been published. The aim of this work is to establish a system of acronym naming that provides consistency in current acronym usage and a foundation for creating acronyms for future VOC metabolites. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to volatile organic compound metabolite acronym standardized naming system, acronyms, biomonitoring, mercapturic acids, naming systems, volatile organic compound metabolites, volatile organic compounds and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 14, 2010, De Vries, Maria Andreas Hendrikus; Domin, Doris; Helms, Matthias; Imboden, Chistoph; Koberstein, Ralph; Nazir, Zarghun; Skranc, Wolfgang; Stanek, Michael; Tschebull, Wilhelm; Verzijl, Maria Gerardus Karel; Stichler, Juergen published a patent.Formula: C9H11NO2 The title of the patent was Process and intermediates for preparation of almorexant hydrochloride.. And the patent contained the following:

(S)-6,7-Dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydro-1H-isoquinoline acetate was prepared via asym. hydrogenation of 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3,4-dihydroisoquinoline in the presence of bis(chloro-1,5-cyclooctadieneiridium), taniaphos, and I2 in a solvent at 1-200 bar H2. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Formula: C9H11NO2

The Article related to almorexant hydrochloride preparation, methoxytrifluoromethylphenylethyldihydroisoquinoline acetate chiral preparation, hydroisoquinoline asym hydrogenation taniaphos cyclopentadiene iridium chloride and other aspects.Formula: C9H11NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2022, Wang, Pu; Lou, Xiaoyi; Chen, Qianqian; Liu, Yujing; Sun, Xiaohu; Guo, Yaoguang; Zhang, Xiaojiao; Wang, Ruixue; Wang, Zhaohui; Chen, Shuai; Zhang, Li; Zhang, Rui-Qin; Guan, Jie published an article.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Spent LiFePO4: An old but vigorous peroxymonosulfate activator for degradation of organic pollutants in water. And the article contained the following:

Iron-based catalysts have been demonstrated to activate peroxymonosulfate (PMS) to generate reactive radicals, which is however limited by their complex preparation process, high costs and inefficiency for practical applications. Herein we obtain spent LiFePO4 (SLFP), with powerful catalytic capacity by a simple one-step treatment of the retired LiFePO4 cathode material, for PMS activation to decontaminate organic pollutants. Lithium defects and oxygen vacancies in SLFP play critical roles for PMS utilization, further confirmed by d. functional theory (DFT) calculations SLFP materials rapidly adsorb PMS, and the surface PMS is activated by Fe(II) to generate radicals, with ·OH playing a major role for the degradation of organics after multi-step reactions. The SLFP/PMS process is finally validated for ability to remove organic contaminants and potential environmental application. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to iron lithium phosphate catalyst peroxymonosulfate activator organic pollutant degradation, advanced oxidation processes, catalysis, hydroxyl radical, peroxymonosulfate, quantum chemical calculations and other aspects.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2022, Zhou, Hao-long; Su, Guan-hua; Zhang, Ru-yi; Di, Dong-sheng; Wang, Qi published an article.COA of Formula: C10H11NO3 The title of the article was Association of volatile organic compounds co-exposure with bone health indicators and potential mediators. And the article contained the following:

Limited evidence was found in the associations of volatile organic compound (VOC) exposure with bone health indicators. This study aimed to explore the associations of individual and combined metabolites of VOCs (mVOCs) in urine, a representative of the internal exposure level of VOCs, with bone mineral d. (BMD), osteoporosis (OP) and fracture, and potential mediators. Data of the National Health Examination and Nutrition Survey 2005-2006 and 2013-2014 was used. Multiple linear and logistic regression modeling were performed to analyze the associations of individual mVOC with bone health indicators. The least absolute shrinkage and selection operator (LASSO) regression was adopted to select mVOCs that were more relevant to bone health indicators for further weight quantile sum (WQS) anal. used for analyzing the associations between multiple VOC co-exposure and bone health indicators. Mediation anal. was used to identify potential mediators. Seventeen mVOC members with detection rate of >50% in urine of all 3478 participants aged ≥20 years (1829 females) were involved. Levels of most mVOCs were higher in women than men. Eight mVOCs were neg. associated with BMDs, and two and four mVOCs were pos. associated with OP and fracture risks, resp. WQS regression revealed decreased femoral neck BMD ( β= -0.010 g/cm2, 95% CI: -0.020, -0.0001) and total spine BMD (β = -0.015 g/cm2, 95% CI: -0.028, -0.002) in response to increasing mVOC mixture levels. And alk. phosphatase (ALP), body mass index (BMI), fasting insulin (FI) and high-d. lipoprotein (HDL), were mediators in the associations with proportions of mediating effect ranging from 4.6% to 10.2%. Individual and combined VOC (co-)exposure were associated with reduced BMDs in American adults. ALP, BMI, FI and HDL were demonstrated to be mediators in the association of multiple VOC co-exposure with BMD. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).COA of Formula: C10H11NO3

The Article related to volatile organic compound bone health indicator body mass index, bone mineral density, co-exposure, mediation, metabolite of volatile organic compound, osteoporosis, weighted quantile sum regression and other aspects.COA of Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics