Month: October 2022

On November 30, 2020, Zhang, Nan; Hu, Xiaoling; Guan, Ping; Xu, Yarong; Liu, Zhuangjian; Cheng, Yuan published an article.Application of 79-07-2 The title of the article was Effect of surface functionality of molecularly imprinted composite nanospheres on specific recognition of proteins. And the article contained the following:

The surface functionality of biomaterial plays a primary role in determining its application in biorecognition and drug delivery. In our work, three types of synthetic tailoring polymer nanospheres with hierarchical architecture were constructed to obtain functional polymer layer with disparate chem. motifs for protein adsorption via surface imprinting and grafting copolymerization In this polymerization system, the structure stability of template protein bovine serum albumin (BSA) is well maintained within a certain range, which facilitated the accurate imprinting and precise identification. A comprehensive protocol for screening different functional layer is proposed through comparing the adsorption behavior, selectivity, identification and responsiveness to medium pH of three functional layers. Our study demonstrates that surface functionality greatly influences the adsorption capacity and selectivity of adsorption material. The functional layer with ionic liquid structure that could only provide multiple non-covalent binding sites is beneficial to the proteins aggregation and extraction, while the anti-nonspecific binding functional layer of biomaterial with zwitterionic structure for specific protein capture is promising to serve as a preferable antigen-antibody communication network, which shows great potential for protein recognition and separation In summary, our proposed strategy provides a systematic selection criterion of biomaterials for effective application in biosensors. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to molecularly imprinted polymer nanocomposite nanosphere surface functionalization, composite nanospheres, molecularly imprinted nanospheres, specific recognition and separation, surface functionality and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohammed, Magdy M. D.; Ibrahim, Nabaweya A.; El-Sakhawy, Fatma S.; Mohamed, Khaled M.; Deabes, Doaa A.-H. published an article in 2016, the title of the article was Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Two new cytotoxic furoquinoline alkaloids were isolated from the leaves of Aegle marmelos (Linn.) Correa; one from the total alkaloidal fraction (acid/base shake-out method) of the CHCl3 extract and identified as 7,8-dihydroxy-4-hydrofuroquinoline and named trivially as Aegelbine-A. The other new alkaloid isolated from the pet. ether extract and identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline and named trivially as Aegelbine-B, together with a known alkaloid; aegeline and a known phenolic acid; ρ-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and HR-ESI/MS. The cytotoxic activity of the isolated compounds was evaluated in vitro against HepG-2, PC3, A549 and MCF-7 cell lines. The obtained results revealed promising activity with structure-based relationship which is discussed briefly. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to mol structure cytotoxic furoquinoline alkaloid aegle aegelbine human antitumor, aegle marmelos (linn.) correa, cytotoxicity, furoquinoline alkaloids, rutaceae, structure–activity relationship studies and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hu, Yawen; Chen, Jianzhong; Li, Bowen; Zhang, Zhenfeng; Gridnev, Ilya D.; Zhang, Wanbin published an article in 2020, the title of the article was Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates.SDS of cas: 27115-50-0 And the article contains the following content:

Earth-abundant nickel, coordinated with a suitable chiral bisphosphine ligand was found to be an efficient catalyst for the asym. hydrogenation of 2-amidoacrylates affording the chiral α-amino acid esters in quant. yields and excellent enantioselectivity (up to 96% ee). The active catalyst component was studied by NMR and HRMS, which helped us to realized high catalytic efficiency on a gram scale with a low catalyst loading (S/C=2000). The hydrogenated products could be simply converted into chiral α-amino acids, β-amino alcs. and their bioactive derivatives Furthermore, the catalytic mechanism was investigated using deuterium-labeling experiments and computational calculations The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to amidoacrylate preparation nickel catalyst enantioselective hydrogenation, amido carboxylate preparation, 2-amidoacrylates, asymmetric hydrogenation, chiral α-amino acids, homogeneous catalysis, nickel and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 20, 2020, Vinogradova, Ekaterina V.; Zhang, Xiaoyu; Remillard, David; Lazar, Daniel C.; Suciu, Radu M.; Wang, Yujia; Bianco, Giulia; Yamashita, Yu; Crowley, Vincent M.; Schafroth, Michael A.; Yokoyama, Minoru; Konrad, David B.; Lum, Kenneth M.; Simon, Gabriel M.; Kemper, Esther K.; Lazear, Michael R.; Yin, Sifei; Blewett, Megan M.; Dix, Melissa M.; Nguyen, Nhan; Shokhirev, Maxim N.; Chin, Emily N.; Lairson, Luke L.; Melillo, Bruno; Schreiber, Stuart L.; Forli, Stefano; Teijaro, John R.; Cravatt, Benjamin F. published an article.Application of 79-07-2 The title of the article was An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. And the article contained the following:

Electrophilic compounds originating from nature or chem. synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understanding of electrophile-sensitive cysteines in the human immune proteome remains limited. Here, we present a global map of cysteines in primary human T cells that are susceptible to covalent modification by electrophilic small mols. More than 3,000 covalently liganded cysteines were found on functionally and structurally diverse proteins, including many that play fundamental roles in immunol. We further show that electrophilic compounds can impair T cell activation by distinct mechanisms involving the direct functional perturbation and/or degradation of proteins. Our findings reveal a rich content of ligandable cysteines in human T cells and point to electrophilic small mols. as a fertile source for chem. probes and ultimately therapeutics that modulate immunol. processes and their associated disorders. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to electrophile cysteine interaction primary human t cell immunol, birc3, itk, t cells, activity-based protein profiling, chemical proteomics, covalent, cysteine, electrophiles, human, protein degradation and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 1, 2020, Verdugo, Edgard M.; Gifford, Mac; Glover, Caitlin; Cuthbertson, Amy A.; Trenholm, Rebecca A.; Kimura, Susana Y.; Liberatore, Hannah K.; Richardson, Susan D.; Stanford, Benjamin D.; Summers, R. Scott; Dickenson, Eric R. V. published an article.Application of 79-07-2 The title of the article was Controlling disinfection byproducts from treated wastewater using adsorption with granular activated carbon: Impact of pre-ozonation and pre-chlorination. And the article contained the following:

This study measured chlorine- and chloramine-reactive precursors using formation potential (FP) tests of nine U. S. Environmental Protection Agency (EPA) regulated and 57 unregulated disinfection byproducts (DBPs) in tertiary-filtered wastewater before and after pilot-scale granular activated carbon (GAC) adsorption. Using breakthrough of precursor concentration and of concentration associated calculated cytotoxicity and genotoxicity (by correlating known lethal concentrations reported elsewhere), the performance of three parallel GAC treatment trains were compared against tertiary-filtered wastewater: ozone/GAC, chlorine/GAC, and GAC alone. Results show GAC alone was the primary process, vs. ozone or chlorine alone, to remove the largest fraction of total chlorine- and chloramine-reactive DBP precursors and calculated cytotoxicity and genotoxicity potencies. GAC with pre-ozonation removed the most chlorine- and chloramine-reactive DBP precursors followed by GAC with pre-chlorination and lastly GAC without pre-treatment. GAC with pre-ozonation produced an effluent with cytotoxicity and genotoxicity of DBPs from FP that generally matched that of GAC without pre-oxidation; meanwhile removal of toxicity was greater by GAC with pre-chlorination. The cytotoxicity and genotoxicity of DBPs from FP tests did not scale with DBP concentration; for example, more than 90% of the calculated cytotoxicity resulted from 20% of the DBPs, principally from haloacetaldehydes, haloacetamides, and haloacetonitriles. The calculated cytotoxicity and genotoxicity from DBPs associated with FP-chloramination were at times higher than with FP-chlorination though the concentration of DBPs was five times higher with FP-chlorination. The removal of DBP precursors using GAC based treatment was at least as effective as removal of DOC (except for halonitromethanes for GAC without pre-oxidation and with pre-chlorination), indicating DOC can be used as an indicator for DBP precursor adsorption efficacy. However, the DOC was not a good surrogate for total cytotoxicity and genotoxicity breakthrough behavior, therefore, unregulated DBPs could have neg. health implications that are disconnected from general water quality parameters, such as DOC, and regulated classes of DBPs. Instead, cytotoxicity and genotoxicity correlate with the concentration of specific classes of unregulated DBPs. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to carbon pre ozonation chlorination cytotoxicity adsorption, chlorine and chloramine disinfection byproducts, cytotoxicity, genotoxicity, granular activated carbon adsorption, potable reuse, preoxidation and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2017, Kumar, Prashant; Takayesu, Allen; Abbasi, Usama; Kalathottukaren, Manu Thomas; Abbina, Srinivas; Kizhakkedathu, Jayachandran N.; Straus, Suzana K. published an article.Category: amides-buliding-blocks The title of the article was Antimicrobial peptide-polymer conjugates with high activity: Influence of polymer molecular weight and peptide sequence on antimicrobial activity, proteolysis, and biocompatibility. And the article contained the following:

We report the synthesis, characterization, activity, and biocompatibility of a novel series of antimicrobial peptide-polymer conjugates. Using parent peptide aurein 2.2, we designed a peptide array (∼100 peptides) with single and multiple W and R mutations and identified antimicrobial peptides (AMPs) with potent activity against Staphylococcus aureus (S. aureus). These novel AMPs were conjugated to hyperbranched polyglycerols (HPGs) of different mol. weights and number of peptides to improve their antimicrobial activity and toxicity. The cell and blood compatibility studies of these conjugates demonstrated better properties than those of the AMP alone. However, conjugates showed lower antimicrobial activity in comparison to that of peptides, as determined from minimal inhibition concentrations (MICs) against S. aureus, but considerably better than that of the available polymer-AMP conjugates in the literature. In addition to measuring MICs and characterizing the biocompatibility, CD spectroscopy was used to investigate the interaction of the novel conjugates with model bacterial biomembranes. Moreover, the novel conjugates were exposed to trypsin to evaluate their stability. It was found that the conjugates resist proteolysis in comparison with unprotected peptides. The peptide conjugates were active in serum and whole blood. Overall, the results show that combining a highly active AMP and low-mol.-weight HPG yields bioconjugates with excellent biocompatibility, MICs below 100 μg/mL, and proteolytic stability, which could potentially improve its utility for in vivo applications. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Category: amides-buliding-blocks

The Article related to antimicrobial peptide polymer conjugate proteolysis biocompatibility, hyperbranched polyglycerol, antimicrobial peptide−polymer conjugates, aurein peptides, biocompatibility, bioconjugation, proteolysis and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Shibo; Takamatsu, Kazutaka; Hirano, Koji; Miura, Masahiro published an article in 2018, the title of the article was Nickel-Catalyzed Stereospecific C-H Coupling of Benzamides with Epoxides.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

A Ni(OAc)2-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with epoxides has been developed. The reaction proceeds with concomitant removal of the 8-aminoquinoline auxiliary to form the corresponding 3,4-dihydroisocoumarins directly. Addnl., the nickel catalysis is stereospecific, and the cis- and trans-epoxides are converted into the corresponding cis- and trans-dihydroisocoumarins with retention of configuration, which is complementary to previously reported palladium catalysis. Moreover, while still preliminary, the Csp3-H functionalization is also achieved in the presence of modified NiCl2 catalysts. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to aminoquinoline benzamide epoxide nickel stereospecific coupling catalyst microwave irradiation, dihydroisocoumarin stereoselective preparation, c−h coupling, epoxides, lactones, nickel, stereospecificity and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 4, 2002, Taran, Frederic; Gauchet, Cecile; Mohar, Barbara; Meunier, Stephane; Valleix, Alain; Renard, Pierre Yves; Creminon, Christophe; Grassi, Jacques; Wagner, Alain; Mioskowski, Charles published an article.Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide The title of the article was Communications: High-throughput screening of enantioselective catalysts by immunoassay. And the article contained the following:

Immunoassay techniques are demonstrated for anal. of catalytic activity of a combinatorial library of enantioselective reduction catalysts. By using an antibody that binds indiscriminately to the two enantiomers of the reduction product, the yield of the reaction can be calculated, and subsequently employing an enantiospecific antibody the enantiomeric excess can be determined This method was demonstrated on a combinatorial library of reduction catalyst prepared by combining a set of 22 chiral diamine-based ligands, e.g., I, with four different metal species. As a model reaction, the enantioselective reduction of benzoyl formic acid to (S)-mandelic acid was studied identifying the optimal catalyst as a combination of [RuCl2(p-cym)]2 with the chiral diamine ligand I. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

The Article related to combinatorial library enantioselective reduction catalyst, high throughput immunoassay screening catalyst library, benzoyl formic acid enantioselective reduction, mandelic acid stereoselective preparation and other aspects.Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 25, 2007, Kansal, Kinod Kumar; Ahmad, Suhail; Mariappan, Shanmugavel; Tyagi, Bhupendra; Perlman, Nurit; Le Paih, Jacques; Zanotti-Gerosa, Antonio published a patent.Recommanded Product: N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide The title of the patent was Processes for the synthesis of azetidinone. And the patent contained the following:

Provided were intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided were processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe (I). The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Recommanded Product: N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

The Article related to azetidinone ezetimibe analog preparation drug delivery system, cholesterol absorption inhibitor azetidinone ezetimibe analog preparation, stereoselective reduction ruthenium catalyst ezetimibe preparation and other aspects.Recommanded Product: N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Nanda, Tanmayee; Biswal, Pragati; Pati, Bedadyuti Vedvyas; Banjare, Shyam Kumar; Ravikumar, Ponneri Chandrababu published an article.Formula: C13H12N2O The title of the article was Palladium-Catalyzed C-C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides. And the article contained the following:

Strain-driven palladium/N-heterocyclic carbene-catalyzed C-C bond activation of diphenylcyclopropenone (DPC) was explored for one-step access to trisubstituted α,β-unsaturated esters and amides. The designed transformation worked under mild conditions providing exclusively a single stereoisomer. Mechanistic studies support the oxidative addition of the C-C bond of cyclopropenone to in-situ-generated Pd(0) intermediate. Vinylic hydrogen in the product was proved that it is coming from phenol/aniline through deuterium-labeling studies. Late-stage functionalization of bioactive mols. such as procaine, estrone, and hymecromone demonstrated the robustness of this protocol. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Formula: C13H12N2O

The Article related to trisubstituted unsaturated ester preparation, phenol cyclopropenone bond activation palladium catalyst, amide trisubstituted unsaturated preparation, amine cyclopropenone bond activation palladium catalyst and other aspects.Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics