Month: October 2022

On January 15, 2015, Xu, Xiao; Wang, Xiaobo; Mao, Long; Zhao, Li; Xi, Biao published a patent.Related Products of 16230-24-3 The title of the patent was Preparation of pyrimidine compounds as Btk and Jak kinase inhibitors. And the patent contained the following:

The present invention relates to heterocyclic compounds [I; R1 = H, NRcRd, or 3-7 member cyclic ring substituted with C1-5 alkyl optionally substituted with halo; Rc = H, C1-4 alkyl or 3-7 member cyclic ring; Rd = H or C1-4 alkyl optionally substituted with OZ; Z = H or C1-4 alkyl; R2 = H, halo, C1-4 alkyl, or C1-4 alkoxy; R3 = H, halo, C1-4 alkyl, or C1-4 alkoxy; R5 = H, halo, C1-4 alkyl, or C1-4 alkoxy; R6 = H, halo, C1-4 alkyl, or C1-4 alkoxy; or R1 and R5 are part of 3-7 member cyclic ring, optionally substituted with C1-4 alkyl substituted with OZ; or R1 and R2 are part of 3-7 member cyclic ring, optionally substituted with C1-4 alkyl substituted with OZ; or R2 and R6 are part of 3-7 member cyclic ring, optionally substituted with C1-4 alkyl substituted with OZ; R4 = C2 alkenyl optionally substituted with C1-4 alkyl, CH2OMe, or -CH2NMe2; X = O, C1-4 alkyl optionally substituted with halo, or NRb; Rb = H, or C1-5 alkyl optionally substituted with halo; Y = CH optionally substituted with halo, or N, wherein at least one of R2, R3, R5 and R6 is not H] or pharmaceutically acceptable salts thereof. It also relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, cancer, tumor, inflammatory disease, autoimmune disease, psoriasis, dry eye or immunol. related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the resp. pathways. Thus, etherification of 2,4-dichloro-5-methoxypyrimidine with 3-nitrophenol in the presence of K2CO3 in DMF at 30 ° for 24 h gave 2-chloro-5-methoxy-4-(3-nitrophenoxy)pyrimidine which was coupled with 4-(4-methylpiperazin-1-yl)aniline in the presence of X-Phos and Pd2(dba)3, and K2CO3 in tert-Bu alc. at refluxing for 4 h to give 5-methoxy-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-(3-nitrophenoxy)pyrimidin-2-amine (II; R = NO2). Hydrogenation of II (R = NO2) in the presence of 10% Pd-C in THF under hydrogen pressure of 15 MPa gave II (R = NH2) which was acylated by acryloyl chloride in the presence of diisopropylethylamine in a mixture of MeOH and THF at 0° with stirring for 1 h to give II (R = acryloylamino), namely N-[3-[[5-methoxy-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]oxy]phenyl]acrylamide. II (R = acryloylamino) showed IC50 of ≤200 nM against Jak3 phosphorylation in NK-92 cells and that of ≤10 nM against Btk Tyr223 phosphorylation in Ramos cells. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Related Products of 16230-24-3

The Article related to piperazinylphenylaminopyrimidine preparation btk jak kinase inhibitor, pyrimidine preparation btk jak kinase inhibitor, piperazinylphenylaminopyrimidinyloxyphenylacrylamide preparation btk jak kinase inhibitor, proliferative disorder cancer tumor treatment pyrimidine preparation and other aspects.Related Products of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2020, Ebrahimi, Amirhossein; Rezazadeh, Mostafa; Khosravi, Hormoz; Rostami, Ali; Al-Harrasi, Ahmed published an article.Application of 5455-98-1 The title of the article was An Aminopyridinium Ionic Liquid: A Simple and Effective Bifunctional Organocatalyst for Carbonate Synthesis from Carbon Dioxide and Epoxides. And the article contained the following:

An aminopyridinium ionic liquid was presented as a green, tunable, and active metal-free one-component catalytic system for the atom-efficient transformation of oxiranes and CO2 to cyclic carbonates. Inclusion of a pos. charged moiety into aminopyridines, through a simple single-step synthesis, provided a one-component ionic liquid catalytic system with superior activity; effective in ring opening of epoxide, CO2 inclusion, and stabilization of oxoanionic intermediates. An efficiency assessment of a variety of pos. charged aminopyridines was pursued, and the impact of temperature, catalyst loading, and the kind of nucleophile on the catalytic performance was also investigated. Under solvent-free conditions, this bifunctional organocatalytic system was used for the preparation of 18 examples of cyclic carbonates from a broad range of alkyl- and aryl-substituted oxiranes and CO2, where up to 98% yield and high selectivity were achieved. DFT calculations validated a mechanism in which nucleophilic ring-opening and CO2 inclusion occur simultaneously towards cyclic carbonate formation. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to aminopyridinium ionic liquid organocatalyst preparation green chem, oxirane carbon dioxide aminopyridinium iodide organocatalyst cycloaddition reaction mechanism, dioxolanone preparation, carbon dioxide, hydrogen-bond donors, ionic liquids, organocatalysis, ring-opening reactions and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 25, 2022, Qaroush, Abdussalam K.; Alsayyed, Ahed W.; Eftaiha, Ala’a F.; Al-Qaisi, Feda’a M.; Salameh, Bader A. published an article.Recommanded Product: 102-07-8 The title of the article was Green Microwave-Assisted Synthesis of Cyclic/Acyclic Ureas from Propylene Carbonate. And the article contained the following:

Herein, an organocatalyzed synthetic pathway for the preparation of acyclic ureas RHNC(O)NHR (R = Bu, sec-Bu, Ph, cyclohexyl, cyclohexylmethyl, benzyl)/cyclic ureas I (n = 1, 2) from their parent primary aliphatic or aromatic monoamines NH2(CH2)nCH2NH2/diamines RNH2 with propylene carbonate as a carbonylating agent obtaining reasonable to very good yields with high selectivity has been described. This method is considered green as nine out of twelve green chem. principles (GCPs) are fulfilled. Most importantly, the absence of solvent and, energy-efficient pathway, in addition to the ease of synthesis and separation, under fast reaction times down to a few minutes together with the straightforward workup with min. use of organic solvents are described. This method was successful in preparing 1,3-diphenylurea from aniline giving 8% yield in 10 min, which was not previously reported using aromatic amines with carbonate esters. The method is applicable for primary rather than secondary amines, which implies high chemoselectivity of the former for the synthesis of urea compounds The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 102-07-8

The Article related to acyclic urea preparation green chem microwave chemoselective, primary amine propylene carbonate carbonylation diazabicycloundecene catalyst, cyclic urea preparation green chem microwave chemoselective, diamine primary propylene carbonate carbonylation diazabicycloundecene catalyst and other aspects.Recommanded Product: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 1, 2021, Pereira, Kelly L.; Ward, Martyn W.; Wilkinson, John L.; Sallach, Jonathan Brett; Bryant, Daniel J.; Dixon, William J.; Hamilton, Jacqueline F.; Lewis, Alastair C. published an article.Application In Synthesis of 1,3-Diphenylurea The title of the article was An automated methodology for non-targeted compositional analysis of small molecules in high complexity environmental matrices using coupled ultra performance liquid chromatography orbitrap mass spectrometry. And the article contained the following:

The life-critical matrixes of air and water are among the most complex chem. mixtures that are ever encountered. Ultrahigh-resolution mass spectrometers, such as the Orbitrap, provide unprecedented anal. capabilities to probe the mol. composition of such matrixes, but the extraction of non-targeted chem. information is impractical to perform via manual data processing. Automated non-targeted tools rapidly extract the chem. information of all detected compounds within a sample dataset. However, these methods have not been exploited in the environmental sciences. Here, we provide an automated and (for the first time) rigorously tested methodol. for the non-targeted compositional anal. of environmental matrixes using coupled liquid chromatog.-mass spectrometric data. First, the robustness and reproducibility was tested using authentic standards, evaluating performance as a function of concentration, ionization potential, and sample complexity. The method was then used for the compositional anal. of particulate matter and surface waters collected from worldwide locations. The method detected >9600 compounds in the individual environmental samples, arising from critical pollutant sources, including carcinogenic industrial chems., pesticides, and pharmaceuticals among others. This methodol. offers considerable advances in the environmental sciences, providing a more complete assessment of sample compositions while significantly increasing throughput. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to automated methodol nontargeted compositional analysis small mol environmental matrixes, coupled ultra performance liquid chromatog orbitrap mass spectrometry, compound discoverer, liquid chromatography−mass spectrometry, non-targeted analysis, ultrahigh-resolution mass spectrometry and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2019, Hu, Cong; Yang, Zhen; Yan, Fuhua; Sun, Biancheng published an article.Formula: C10H11NO3 The title of the article was Extraction of the toluene exposure biomarkers hippuric acid and methylhippuric acid using a magnetic molecularly imprinted polymer, and their quantitation by LC-MS/MS. And the article contained the following:

A magnetic polymer was molecularly imprinted with hippuric acid (HA) to obtain a nanomaterial with an architecture of type Fe3O4@SiO2@MIP. It was used as a sorbent for magnetic solid phase extraction of HA and methylhippuric acids (2-MHA, 3-MHA, 4-MHA) from urine samples. The resp. imprinting factor are 4.6, 2.7, 2.0 and 1.8, resp., and the selectivity coefficients are 1.7, 2.3 and 2.6. The effects of adsorbent amount, extraction time, pH value, ionic strength, desorption solvent and desorption time on the extraction of HA and MHA were investigated. Following elution with 1 mM NaOH solution, the 4 HAs were quantified by ultra-performance liquid chromatog. with mass spectrometric detection. Under the optimal exptl. conditions, the limits of detection (at S/N = 3) range between 89 ng·L-1 (for HA) and 170 ng·L-1 (for 4-MHA), the limits of quantification (at S/N = 10) range between 300 ng·L-1 (for HA) and 570 ng·L-1 (for 4-MHA), the linear range extends from 500 ng·L-1 to 10 mg·L-1, the relative standard deviations of intra-day range between 6.4 and 9.6% (for n = 6 at 10μg·L-1) and inter-day range between 9.2 and 11.5% (for n = 6 at 10μg·L-1). The method was successfully applied to the anal. of HA and MHA in (spiked) urine, and good recoveries were obtained. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Formula: C10H11NO3

The Article related to lc ms toluene biomarker hippuric methylhippuric acid polymer china, fourier transform infrared spectrometry, magnetic solid phase extraction, transmission electron microscopy, ultrasonic liquid desorption, urine analysis, vortex-assisted extraction, x-ray photoelectron spectroscopy and other aspects.Formula: C10H11NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parzuchowski, Pawel G.; Swiderska, Aleksandra; Roguszewska, Marlena; Rolinska, Karolina; Wolosz, Dominik; Maminski, Mariusz published an article in 2020, the title of the article was Hyperbranched poly(ether-siloxane)s containing ammonium groups: Synthesis, characterization and catalytic activity.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

In this article we report an easy synthetic route towards hyperbranched polyglycerols (Amm-HBPGs) containing trimethylammonium groups and siloxane or hydroxyl end-groups. Siloxane derivatives of Amm-HBPGs were synthesized in an efficient five-step procedure including an anionic ring opening copolymerization of the phthalimide-epoxy monomer with glycidol, followed by reactions with allyl bromide, hydrosilylation with hydrogenheptamethyltrisiloxane, hydrazinolysis of phthalimide groups and quaternization of resulting amine groups with Me iodide. Hydroxyl derivatives were obtained by quaternization of previously reported aminated HBPG’s with Me iodide. Polymeric products were characterized using various NMR techniques, FTIR, and elemental anal. Both Amm-HBPGs were shown to be effective in catalysis of addition of CO2 to oxirane. The hydrophilic catalysts showed higher efficiency but synthesis of ethylene carbonate was accompanied by formation of small amounts of ethylene glycol. The siloxane-containing catalyst was easily separable from reaction mixture showing high potential in the process of converting carbon dioxide into valuable chem. raw materials. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to trimethylammonium polyether siloxane hyperbranched polymer anionic ring opening copolymerization, carbon dioxide oxirane ethylene carbonate cycloaddition catalyst, carbon dioxide, catalysis, cycloaddition, ethylene carbonate, hyperbranched polymer, oxirane, polyglycidol, polysiloxane and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Knippen, Katharina; Bredenkoetter, Bjoern; Kanschat, Lisa; Kraft, Maryana; Vermeyen, Tom; Herrebout, Wouter; Sugimoto, Kunihisa; Bultinck, Patrick; Volkmer, Dirk published an article in 2020, the title of the article was CFA-18: a homochiral metal-organic framework (MOF) constructed from rigid enantiopure bistriazolate linker molecules.COA of Formula: C2H4ClNO And the article contains the following content:

In this work, authors introduce the first enantiopure bistriazolate-based metal-organic framework, CFA-18 (Coordination Framework Augsburg-18), built from the R-enantiomer of 7,7,7′,7′-tetramethyl-6,6′,7,7′-tetrahydro-3H,3’H-5,5′-spirobi[indeno[5,6-d]-[1,2,3]triazole] (H2-spirta). The enantiopurity and absolute configuration of the new linker were confirmed by several chiroselective methods. Reacting H2-spirta in hot N,N-dimethylformamide (DMF) with manganese(II) chloride gave CFA-18 as colorless crystals. The crystal structure with the composition [Mn2Cl2(spirta)(DMF)2] was solved using synchrotron single-crystal x-ray diffraction. CFA-18 shows a framework topol. that is closely related to previously reported metal-azolate framework (MAF) structures in which the octahedrally coordinated manganese(II) ions are triazolate moieties, and the chloride anions form crosslinked one-dimensional helical chains, giving rise to hexagonal channels. In contrast to MAFs crystallizing in the centrosym. space group R3, the handedness of the helixes found in CFA-18 is strictly uniform, leading to a homochiral framework that crystallizes in the trigonal crystal system within the chiral space group P3121 (number 152). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to tetramethyltetrahydrospiro biindenediol homochiral metal organic framework preparation crystal structure, mof rigid enantiopure bistriazolate linker mol preparation crystal structure, manganese tetramethyltetrahydrospiro biindenediol homochiral metal organic framework preparation structure and other aspects.COA of Formula: C2H4ClNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 8, 2021, Kumar, Vishal; Dhawan, Sanjeev; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application of 685-91-6 The title of the article was An Environmentally Benign, Catalyst-Free N-C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides. And the article contained the following:

An operationally simple, cheap and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol was environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy was implied in the chemoselective synthesis of a pharmaceutical mol., paracetamol, on a gram-scale with excellent yield. Anticipated that this was universally applicable strategy will be of great interest in drug discovery, biochem., and organic synthesis. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application of 685-91-6

The Article related to formamide amine hydrochloride n formylation transamidation green chem, arylformamide preparation, acetamide amine hydrochloride n acylation transamidation green chem, arylacetamide preparation, benzamide amine hydrochloride n benzoylation transamidation green chem, arylbenzamide preparation and other aspects.Application of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2015, Wan, Yichao; Wu, Shaolei; Xiao, Guizhi; Liu, Tingting; Hou, Xuben; Chen, Chen; Guan, Peng; Yang, Xinying; Fang, Hao published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. And the article contained the following:

The B-cell lymphoma-2 (Bcl-2) protein is a promising target for cancer therapy. In the present study, a series of 2-thioxo-4-thiazolidinone derivatives were designed and synthesized as Bcl-2 inhibitors. Most of them possessed decent inhibitory activity for anti-apoptotic Bcl-2 proteins. Among them, compound I has similar growth inhibition towards K562 compared to (R)-Gossypol. In addition, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Ki value of 74 nM. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to thioxothiazolidinone derivative preparation preliminary bioactivity bcl2 inhibitor, oxothiazolidinethione derivative preparation preliminary bioactivity bcl2 inhibitor, cancer therapy growth inhibition thioxothiazolidinone derivative, 2-thioxo-4-thiazolidinone, anti-tumor, bcl-2, inhibitors and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2016, Toda, Yasunori; Komiyama, Yutaka; Kikuchi, Ayaka; Suga, Hiroyuki published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Tetraarylphosphonium Salt-Catalyzed Carbon Dioxide Fixation at Atmospheric Pressure for the Synthesis of Cyclic Carbonates. And the article contained the following:

Phosphonium salts exhibit great utility in organic synthesis. However, tetraarylphosphonium salts (TAPS) have found limited use as catalysts. We demonstrate the TAPS-catalyzed carbon dioxide fixation at atm. pressure for the coupling reaction with epoxides. Five-membered cyclic carbonates were obtained, including enantio-enriched carbonates. Mechanistic studies revealed the origin of the behavior of TAPS to be the in situ formation of an active species by TAPS addition to epoxides via halohydrin intermediates. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to cyclic carbonate preparation carbon dioxide fixation epoxide atm pressure, tetraarylphosphonium salt preparation catalyst carbon fixation, crystal mol structure hydroxy methylphenyl triphenylphosphonium bromide, carbon dioxide fixation tetraarylphosphonium salt catalyzed epoxide atm pressure and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics