Month: October 2022

On October 28, 2020, Wu, Qiumin; Chen, Jinzhu; Liu, Zhen; Xu, Yisheng published an article.Name: 1,3-Diphenylurea The title of the article was CO Activation Using Nitrogen-Doped Carbon Nanotubes for Reductive Carbonylation of Nitroaromatics to Benzimidazolinone and Phenyl Urea. And the article contained the following:

Carbonylation of nitroaroms. with CO is extensively investigated with efficient but precious group 8-10 metal-based catalysts for the productions of both industrially and academically important chems. such as isocyanates, formamides, carbamates, ureas and several types of heterocyclic compounds Herein, we report that rationally designed nitrogen-doped carbon nanotubes (N-CNTs) exhibit catalytic activity toward CO activation for carbonylation of nitroaroms. to benzimidazolinones and ureas. Under the optimal conditions, N-CNT-promoted intramol. carbonylation of 2-nitroaniline (1a) with CO leads to formation of 1,3-dihydro-2H-benzo[d]imidazol-2-one in 90% yield. Moreover, an intermol. carbonylation of nitrobenzene and aniline with CO in the presence of the N-CNT gives 70% yield of N,N’-diphenylurea. The N-CNT is also applicable to various benzimidazolinones and Ph ureas; moreover, it can be readily reused at least 9 times for the carbonylation. The theor. investigation based on d. functional theory calculations indicates that the graphitic N of the N-CNT plays a crucial step in the 1a reduction with CO. The correlation between the structural defect and catalytic performance of the N-CNT reveals an enhanced catalytic activity of the N-CNT with its increased structural defects. This research thus represents a major breakthrough in CO activation for nitroarom. carbonylation with environmental-friendly, low-cost, and carbon-based catalysts as a potential alternative to expensive and scarce noble-metal-based catalysts. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to nitrogen doped carbon nanotube catalyst reductive carbonylation nitroarom aniline, carbon monoxide activation nitrogen doped carbon nanotube, benzimidazolinone ph urea preparation green chem mol modeling, carbon catalysis, carbon monoxide, carbonylation, defect, nitrogen-doped carbon nanotubes and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Xiang; Nguyen, Edward T.; Hong, Anh N.; Feng, Pingyun; Bu, Xianhui published an article in 2018, the title of the article was Chiral Isocamphoric Acid: Founding a Large Family of Homochiral Porous Materials.Safety of N,N-Diethylacetamide And the article contains the following content:

Homochiral metal-organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low-cost, racemization-resistant, and versatile enantiopure building blocks. Among chiral building blocks, D-camphoric acid is highly prolific, yet, its trans-isomer, L-isocamphoric acid, has remained unknown in the entire field of solid-state materials. Its rich yet totally untapped synthetic and structural chem. has now been studied through the synthesis of a large family of homochiral metal isocamphorates. The 1st observation of diastereoisomerism in isostructural MOFs is presented. Isocamphorate has a powerful ability to create framework topologies unexpected from common inorganic building blocks, and isocamphoric acid should allow access to hundreds of new homochiral materials. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Safety of N,N-Diethylacetamide

The Article related to chiral isocamphorate preparation homochiral porous material, transition metal isocamphorate camphorate mof preparation, crystal structure magnesium cobalt copper isocamphorate camphorate mof, camphoric acid, chiral ligands, homochiral porous materials, isocamphoric acid, metal-organic frameworks and other aspects.Safety of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 27, 2017, Mancini, Alessandra; Chelini, Alessia; Di Capua, Angela; Castelli, Loretta; Brogi, Simone; Paolino, Marco; Giuliani, Germano; Cappelli, Andrea; Frosini, Maria; Ricci, Lorenzo; Leonelli, Erminia; Giorgi, Gianluca; Giordani, Antonio; Magistretti, Jacopo; Anzini, Maurizio published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents. And the article contained the following:

The synthesis of differently functionalized 4H-3,1-benzothiazine I and 2H-1,4-benzothiazine II [X = CH2, S; Y = CH2, S; R = H, OCF3; R1 = R2 = H, Me, Et, n-Pr] series as superior homologs of rizuline were reported. Biol. evaluation demonstrated that amidine 4H-3,1-benzothiazine derivatives I [R1 = R2 = H, Et, n-Pr] reduces glutamate and LDH release in the oxygen/glucose deprivation and reperfusion model (OGD/R) applied to brain slices with a higher potency than rizuline. Moreover the mentioned compounds significantly reduced glutamate- and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in neuroblastoma cells. In addition, the same compounds limit ROS formation in both neuronal preparations Finally, compound I [R1 = R2 = Et] proved effective in inhibiting neuronal voltage-dependent Na+ and Ca2+-channels, showed a profile comparable with that of rizuline. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to benzothiazinyl acetamidine preparation neuroprotective agent antioxidant sar, propylthiourea benzothiazinyl preparation neuroprotective agent antioxidant sar, benzothiazine derivatives, neurodegenerative diseases, neuronal voltage-dependent na(+) and ca(2+) currents, neuroprotective agents, sh-sy5y cells and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 15, 2021, Wang, Zhiguo; Li, Shijiang; Li, Ronghao; Luo, Chunyan published a patent.Formula: C6H11NO The title of the patent was Preparation of indoline-5-methylamine dihydrochloride from indole. And the patent contained the following:

The present invention relates to the preparation of indoline-5-methylamine dihydrochloride from indole. In particular, the preparation method comprises of following steps: (1) using indole as a raw material, and reacting with an acid to obtain a formyl-protected indoline; (2) carrying out Friedel-Crafts reaction of the formyl protected indoline with an amination reagent to obtain 5-[(1,3-dioxoisoindolin-2-yl)methyl]indole-1-carbaldehyde; (3) the obtained intermediate compound is treated with hydrazine hydrate to obtain 5-(aminomethyl)indole-1-aminoaldehyde; and (4) carrying out the deprotection reaction of 5-(aminomethyl)indole-1-aminoaldehyde to obtain the target product indoline-5-methylamine dihydrochloride. The inventive method has a short process route, low cost, easy availability of raw materials and auxiliary materials, high reactivity, simple operation, easy control, and has high yield of the target product, which is convenient for industrial scale-up. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Formula: C6H11NO

The Article related to indole formic acid formylation reduction, formylindoline preparation hydroxymethyl phthalimide compound friedel crafts reaction, dioxyisoindolinyl methylindole formaldehyde preparation amination, aminomethyl dihydro indole carboxaldehyde preparation deprotection, indoline methylamine dihydrochloride preparation and other aspects.Formula: C6H11NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2020, Tong, Dan; Chen, Jiangyao; Qin, Dandan; Ji, Yuemeng; Li, Guiying; An, Taicheng published an article.Related Products of 685-91-6 The title of the article was Mechanism of atmospheric organic amines reacted with ozone and implications for the formation of secondary organic aerosols. And the article contained the following:

Organic amines are a most important N-containing compounds in the atm.; their reactions with tropospheric O3 significantly contribute to secondary organic aerosols (SOA) formation. But the chem. pathways of their reaction with atm. O3 are poorly understood. This work examined the atm. ozonolysis mechanism for two typical organic amines (diethylamine, triethylamine) using exptl. and theor. methods. Intermediate gas chromatog./mass spectrometry and proton transfer reaction /time-of-flight mass spectrometry anal. results confirmed formation of 8 and 11 N- and O-containing products during diethylamine and triethylamine ozonolysis, resp. N-ethylethanimine (average 56.5%) or acetaldehyde (average 64.9%) was formed as the dominant product from ozonolysis of each organic amine. Ozonolysis pathway results indicated conversion to N-ethylethanimine was the dominant pathway for diethylamine ozonolysis. Simultaneously, triethylamine preferred an initial transformation to diethylamine with discharge of acetaldehyde then conversion to N-ethylethanimine. Higher SOA mass concentrations were obtained from triethylamine vs. diethylamine ozonolysis, probably because the former released a larger amount of intermediate products, particularly acetaldehyde. Results provided a deep insight into atm. processing of organic amines via ozonolysis and implications of this mechanism for SOA formation. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to atm ozonolysis organic amine secondary organic aerosol formation, diethylamine triethylamine atm ozonolysis secondary organic aerosol formation, reaction pathway transformation mechanism organic amine atm ozonolysis, ozonolysis intermediate byproduct organic amine reaction, atmospheric organic amine, carbonyl intermediate and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 2, 2022, Franchino, Allegra; Marti, Alex; Echavarren, Antonio M. published an article.Electric Literature of 102-07-8 The title of the article was H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis. And the article contained the following:

A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asym. induction. The successful implementation of this paradigm is demonstrated in 5-exo-dig and 6-endo-dig cyclizations of 1,6-enynes, combining an achiral phosphinourea Au(I) chloride complex with a BINOL-derived phosphoramidate Ag(I) salt and thus allowing the 1st general use of chiral anions in Au(I)-catalyzed reactions of challenging alkyne substrates. Experiments with modified complexes and anions, 1H NMR titrations, kinetic data, and studies of solvent and nonlinear effects substantiate the key H-bonding interaction at the heart of the catalytic system. This conceptually novel approach, which lies at the intersection of metal catalysis, H-bond organocatalysis, and asym. counterion-directed catalysis, provides a blueprint for the development of supramolecularly assembled chiral ligands for metal complexes. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to silver binaphtholphosphinate preparation catalyst enyne cyclization crystal structure, crystal structure silver binaphtholphosphinate gold phosphinothiourea complex, mol structure silver binaphtholphosphinate gold phosphinothiourea complex, gold phosphinothiourea complex preparation catalyst enyne cyclization crystal structure and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 24, 2016, Shia, Kak-Shan; Jan, Jiing-Jyh; Tsou, Lun Kelvin; Chen, Chiung-Tong; Chao, Yu-Sheng published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of quinazoline heterocyclic compounds and use thereof to mobilize hematopoietic stem cells and endothelial progenitor cells. And the patent contained the following:

Heterocyclic compounds I [wherein: M = (CH2)m; each of R1 and R2, independently, is H, halogen, NO2, CN, NH2, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; or, R1 and R2, together with the two carbon atoms to which they are bonded, are C5-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl, each of alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [Each of R3 and R4, independently, is NRbRc, Z1 or Z2; in which: each of Rb and Rc, independently, is H or C1-6-alkyl;R5 is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, arylalkyl, heteroaryl alkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, aryl, and heteroaryl being optionally substituted;]. [R6 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl;L1 is heteroaryl, C1-10-heterocycloalkyl, NH, or NRd; in which Rd is C(:O)(CH2)2CHNH2CO2Re; Re being H, C1-6-alkyl, C3-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl;R7 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, alkoxyl, cycloalkyl,heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [M is 1 – 6; n is 1 – 6; each of R8 and R9, independently, is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted; L2 is C1-6-alkyl; or L2, together with R8 8or R9 and the nitrogen atom to which they are bonded, is C4-10-heterocycloalkyl or heteroaryl; and,]. [R10 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, ester, amide thioamide, or acyl; each of alkyl, alkoxyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl alkyl, and heteroaryl alkyl being optionally substituted] are shown herein. Thus, quinazoline II was prepared from 2,4-dichloroquinazoline via amination with tert-Bu 4-aminopiperidine-1-carboxylate; amination with aminotriazle III; and debutoxycarbonylation. The synthesis of II is also desribed. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to heterocyclic compound preparation pharmaceutical composition mobilizer hematopoietic stem cells, tissue injury treatment quinazoline pyrimidine compound, cancer treatment quinazoline pyrimidine compound, inflammatory disease treatment quinazoline pyrimidine compound, autoimmune disease treatment quinazoline pyrimidine compound and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 26, 1998, Potrzebowski, Marek J.; Michalska, Maria; Koziol, Anna E.; Kazmierski, Slawomir; Lis, Tadeusz; Pluskowski, January; Ciesielski, Wlodzimierz published an article.Related Products of 97-09-6 The title of the article was Structural Implications of C-H···S Contacts in Organophosphorus Compounds. Studies of 1,6-Anhydro-2-O-tosyl-4-S-(5,5-dimethyl-2-thioxa-1,3,2-dioxaphosphorinan-2-yl)-β-D-glucopyranose by X-ray and Solid-State NMR Methods. And the article contained the following:

1,6-Anhydro-2-O-tosyl-4-S-(5,5-dimethyl-2-thioxa-1,3,2-dioxaphosphorinan-2-yl)-β-D-glucopyranose (1, C18H25O8PS3), crystallized from polar and/or nonpolar solvents, forms different modifications in the solid phase. Crystal structures of 1 (obtained from a methanol solution) and its 2-propanol solvate (1a) were established by X-ray structure anal. at low temperature One-component crystal 1 is orthorhombic, space group P212121, with a = 7.483(4) Å, b = 11.156 (6) Å, c = 27.11(2) Å, V = 2263 (2) Å3, Z = 4, and Dc = 1.457 g cm-3. The crystal of 1a is an inclusion structure containing mols. of 1 and 2-propanol in the ratio 1/1; crystals are triclinic, space group P1, with a = 9.637(6) Å, b = 9.709(6) Å, c = 8.865(8) Å, α = 110.27(5)°, β = 106.33(5)°, γ = 108.70(6)°, V = 661.3(8) Å3, Z = 1, and Dc = 1.398 g cm-3. Intermol. hydrogen bonds (O-H···O, C-H···O in 1; O-H···O, O-H···S in 1a) are present along with the C-H···S:P intermol. interactions. The solid-state structures were studied by the NMR spectroscopy. The presence of toluene-d8 in the crystal lattice of inclusion complex was confirmed by 2H NMR spectroscopy. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Related Products of 97-09-6

The Article related to toluene inclusion anhydrotosylthioxadioxaphosphorinanyl glucopyranose crystal structure, propanol solvate anhydrotosylthioxadioxaphosphorinanyl glucopyranose crystal structure, intermol hydrogen bond anhydrotosylthioxadioxaphosphorinanyl glucopyranose nmr, mol crystal structure anhydrotosylthioxadioxaphosphorinanyl glucopyranose and other aspects.Related Products of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 1991, Shepard, Kenneth L.; Graham, Samuel L.; Hudcosky, Ronald J.; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Smith, Anthony M.; Sondey, John M.; Strohmaier, Kim M. published an article.Name: 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. And the article contained the following:

For several decades a goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. (Hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides I [R = (CH2)nOH, CH2CH(OH)CH2OH, CH2CH2CMe2OH, etc., n = 2-5; R1 = H, Cl, F, NO2, CO2H, CO2Me, NH2; X = S, SO2] and II [R2 = (CH2)nOH, (CH2)mCO2Me, (CH2)3O2CCH2OMe, (CH2)3O2CCH2CHMe2, (CH2)3NHCH2CHMe2, X = S, SO2, n = 2-4, m = 2, 3] were prepared and examined for carbonic anhydrase inhibitory activity. Thus, condensation of 2-mercaptoethanol with (bromophenylsulfonyl)formamidine III gave I [R = (CH2)2OH, R1 = H, X = S]. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation. The inhibitory potency could be increased by converting a sulfide to the sulfone. Adding an extra methylene into the 4-substituent of benzene derivatives increases the inhibitory potency slightly more than oxidation of the sulfide. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to hydroxyalkylsulfonylbenzenesulfonamide preparation carbonic anhydrase inhibitor, hydroxyalkylsulfonylthiophenesulfonamide preparation carbonic anhydrase inhibitor, carbonic anhydrase inhibitor hydroxyalkylsulfonylbenzenesulfonamide hydroxyalkylsulfonylthiophenesulfonamide, glaucoma treatment alkylsulfonylbenzenesulfonamide thiophenesulfonamide and other aspects.Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 9, 2021, Zhang, Xin; Geng, Peiyu; Liu, Guixia; Huang, Zheng published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Ru-Catalyzed Site-Selective Aliphatic C-H Bond Silylation of Amides and Carbamides. And the article contained the following:

Hydrido Ru complexes (POCNP)RuH(NBD) (NBD = norbornadiene) supported by N/O-bridged pincer ligands were synthesized and characterized. The Ru complex containing a pincer ligand with an indolol scaffold exhibits high catalytic activity for the intermol. aliphatic C-H bond silylation of amides and carbamides. The reaction proceeds selectively at the C-H bonds adjacent to the N atom to efficiently afford α-silyl amides and carbamides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide

The Article related to hydridoruthenium pincer complex containing diphosphinated indolol ligand preparation catalyst, crystal structure hydridoruthenium pincer complex containing diphosphinated indolol ligand, mol structure hydridoruthenium pincer complex containing diphosphinated indolol ligand, diphosphinated indolol ligand preparation cyclometalation ruthenium complex and other aspects.Application In Synthesis of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics