Month: October 2022

The author of 《Synthesis of Imides, Imidates, Amidines, and Amides by Intercepting the Aryne-Isocyanide Adduct with Weak Nucleophiles》 were Ghorai, Sourav; Lee, Daesung. And the article was published in Organic Letters in 2019. Computed Properties of C7H9NO2S The author mentioned the following in the article:

New aryne-based multicomponent coupling reactions for the formation of functionalized aromatic compounds have been developed. Arynes generated from triynes or tetraynes through the hexadehydro Diels-Alder reaction readily react with isocyanide to generate nitrilium intermediate. Intercepting this nitrilium species with various weak nucleophile including carboxylic acids, alcs., sulfonamides, or water generated the corresponding imides, imidates, amidines, or amides. The high regioselectivity of these transformations was mainly controlled by the substituents of the arynes. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Oxidative sulfamidation of vinyl silanes: A route to diverse silylated N-Heterocycles》 were Astakhova, Vera V.; Shainyan, Bagrat A.; Moskalik, Mikhail Yu.; Sterkhova, Irina V.. And the article was published in Tetrahedron in 2019. Product Details of 70-55-3 The author mentioned the following in the article:

The reaction of trimethyl(vinyl)silane 1 and dimethyl(divinyl)silane 2 with various sulfonamides in the oxidative system (tert-BuOCl + NaI) has been studied and shown to be an efficient approach for the synthesis of silylated N-heterocycles. Triflamide demonstrated the reactivity principally different from that of arenesulfonamides. With silane 1, it afforded the products of iodochlorination and bis(triflamidation) (major), whereas arenesulfonamides gave N-arenesulfonylaziridines in up to 91% yield. Silane 2 with arenesulfonamides yielded the products of mono and bis(iodochlorination), mono and bis(aziridination), and 3,5-diiodo-4,4-dimethyl-1-(arylsulfonyl)-1,4-azasilinanes. By contrast, triflamide, apart from the products of halogenation and iodotriflamidation, unexpectedly gave 3-(trifluoromethylsulfonyl)-5-(triflamido)oxazolidine as the main product. The structure of most heterocyclic products is proved by X-ray anal. The effect of the silyl group in the substrate and of the substituent in the reagent on the course of oxidative sulfamidation is discussed by comparing with all-carbon analogs.4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Regio- and Diastereoselective Spirocyclopropanation of Benzofuran-Derived Azadienes through 1,4-Addition-Induced Dearomatization Reaction under Mild Conditions》 was published in Organic Letters in 2020. These research results belong to Fang, Qing-Yun; Yi, Meng-Hao; Wu, Xiao-Xia; Zhao, Li-Ming. Recommanded Product: 4-Methylbenzenesulfonamide The article mentions the following:

A Cs2CO3-mediated [2 + 1] cycloaddition of benzofuran-derived azadienes (BDAs) with bromomalonate by using a dearomatization strategy has been developed. Through this process, BDAs serve as a potential 2-atom synthon in the construction of a range of functionalized spirocyclopropane derivatives, such as spirobenzofuran-2-cyclopropanes and spiroindane-2-cyclopropanes. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation》 was published in Organic Letters in 2020. These research results belong to Lim, Soobin; Cho, Hyungdo; Jeong, Jongheon; Jang, Minjae; Kim, Hyunseok; Cho, Seung Hwan; Lee, Eunsung. Formula: C4H9NO2 The article mentions the following:

Transition-metal-catalyzed transformations of the C-F bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein the authors report a practical Co-catalyzed silylation of aryl fluorides that uses a cheap electrophilic Si source with Mg. This method is compatible with various Si sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic Si source. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Direct Intramolecular Aminoboration of Allenes》 was written by Yang, Chun-Hua; Han, Meng; Li, Wenyan; Zhu, Ningning; Sun, Zhenzhen; Wang, Junjie; Yang, Zhantao; Li, Yue-Ming. COA of Formula: C7H9NO2S And the article was included in Organic Letters in 2020. The article conveys some information:

Direct intramol. aminoboration of sulfonamidoallenes was realized using BCl3 as a boron source. The reactions benefited from the interaction between BCl3 and sulfonamides and provided a variety of borylvinyl heterocycles, e.g. I, in good isolated yields. When chiral substrates were involved in the reactions, high stereoselectivity was observed, as can be ascertained by single-crystal X-ray diffraction experiments Derivatization of the thus-obtained borylvinyl compounds proceeded readily, and different functionalities could be obtained via oxidation, halogenation, and Suzuki coupling reactions. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Peng; Yang, Jiazhi; Ai, Yao; Hao, Shushu; Chen, Xiaozhong; Li, Feng published their research in Journal of Catalysis in 2021. The article was titled 《Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate》.Category: amides-buliding-blocks The article contains the following contents:

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines RNH2 [R = octyl, adamantan-1-yl, naphthalen-2-yl, 1,3-benzoxazol-2-yl, etc.], 1,2,3,4-tetrahydroisoquinoline and 1,3-bis(4-piperidyl)propane with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products RNHCH3, RN(CH3)2, 2-methyl-1,2,3,4-tetrahydroisoquinoline and 1-methyl-4-(3-(1-methylpiperidin-4-yl)propyl)piperidine/R1S(O)2NH(CH3) (R1 = t-Bu, cyclopropyl, 4-chlorophenyl, thiophen-2-yl, etc.) were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst Cp*Ir@CTF could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalyst Cp*Ir@CTF for hydrogen autotransfer process. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Category: amides-buliding-blocks)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kubasov, Alexey S.; Turyshev, Evgeniy S.; Novikov, Ivan V.; Gurova, Olga M.; Starodubets, Polina A.; Golubev, Aleksei V.; Zhizhin, Konstantin Yu.; Kuznetsov, Nikolay T. published their research in Polyhedron in 2021. The article was titled 《Theoretical and experimental comparison of the reactivity of the sulfanyl-closo-decaborate and sulfanyl-closo-dodecaborate anions and their mono-S-substituted derivatives》.Application In Synthesis of 2-Bromoacetamide The article contains the following contents:

In this work, we have extended the method proposed by Gabel for the preparation of mono- and di-S,S-substituted derivatives of sulfanyl-closo-dodecaborate anion [B12H11SH]2- to derivatives of the closo-decaborate anion. The method is based on the β-elimination of the propionitrile group of sulfonium derivatives [BnHn-1S(R)CH2CH2CN]- in the presence of bases with the formation of the corresponding mono-S-substituted derivatives and acrylonitrile. We also calculated the Fukui functions for the nucleophilic attack of the S-atom in the [B10H9SH]2- and [B12H11SH]2- anions and their mono-S-substituted derivatives using the Hirshfeld approach. As a result, the calculated value of nucleophilicity in the [B10H9SH]2- anion was found to be 5-10 times lower than in other compounds, which completely agrees with the exptl. data. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8Application In Synthesis of 2-Bromoacetamide) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application In Synthesis of 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kong, Minjian; Meng, Yan; Fan, Lei; Yin, Chengxian; Chen, Qibin; Liu, Honglai published an article in 2021. The article was titled 《Experimental Study of Poly(1-Acetamide-3-vinylimidazolium Bromide) as a Corrosion Inhibitor for N80 Carbon Steel in HCl》, and you may find the article in ChemistrySelect.HPLC of Formula: 683-57-8 The information in the text is summarized as follows:

A poly(ionic liquid) (PIL), poly(1-acetamide-3-vinylimidazolium bromide) (PCVIB), was investigated as a potential hydrochloric acid corrosion inhibitor for N80 carbon steel (N80-CS) at 25 °C. In this work, the corrosion inhibition properties of PCVIB were monitored using weight loss, potential dynamic polarization (PDP), electrochem. impedance spectroscopy (EIS), SEM (SEM) and XPS. Results show that the maximum inhibition efficiency (IE, η) of PCVIB can reach up to 95.8 %, whereas its monomer only exhibits a low IE of η=33.6 % under the same conditions. Moreover, PCVIB is characteristic of a mixed type inhibitor, which can effectively impede both cathodic hydrogen evolutions and metal dissolution reactions. Addnl., the adsorption of PCVIB on steel surfaces obeys the Langmuir adsorption isotherm. This finding implies that the polymerization can be a viable and facile method to create the high-efficiency inhibitor from monomeric units that were found or used with the poor IE previously. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 71432-55-8In 2014 ,《Enantioselective total synthesis of (-)-scabronine D》 was published in Heterocycles. The article was written by Kobayakawa, Yu; Nakada, Masahisa. The article contains the following contents:

An enantioselective total synthesis of (3aS,5aR,6R,9R,10aR)-8-[(benzoyloxy)methyl]-3,4,5,5a,6,9,10,10a-octahydro-6-hydroxy-5a-methyl-1-(1-methylethyl)-6,9-epoxycyclohept[e]indene-3a(2H)-carboxylic acid [(-)-scabronine D diterpenoid] a which contains bridged hemiacetal group is described. The synthesis of the target compound was achieved using an enantiopure intermediate which was previously reported for a total synthesis of scabronine G and scabronine A and (-)-episcabronine A. Because the advanced intermediate was found to be sensitive to basic reaction conditions, the C14 keto and C11 hydroxy groups had to be co-protected as Me acetal. In addition, both the C15 hydroxy and C17 carboxyl groups were too reactive to be chem. discriminated; hence, the carboxyl group once formed was protected as a tert-Bu ester for ensuring successful transformations. In the experimental materials used by the author, we found tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Product Details of 71432-55-8)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Product Details of 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 70-55-3In 2021 ,《Highly Selective and Catalytic C-N Bond Cleavage of Tertiary Sulfonamides: Scope and Mechanistic Insight》 was published in ACS Omega. The article was written by Bhattacharya, Aditya; Shukla, Pushpendra mani; Maji, Biswajit. The article contains the following contents:

A highly chemoselective C-N bond cleavage reaction of tertiary sulfonamides RN(CH2R1)S(O)2R2 (R = Ph, 3-chlorophenyl, 3,4-dimethoxyphenyl, etc.; R1 = 4-methoxyphenyl, 3,4-dimethoxyphenyl, 2-phenylethenyl, etc.; R2 = 4-methylphenyl, naphthalen-1-yl, 4-nitrophenyl, etc.) in the presence of catalytic Bi(OTf)3 is presented. A wide range of sulfonamide substrates smoothly furnished the corresponding C-N bond cleavage products RNHS(O)2R2 in good to excellent yields. Great efforts have been made to obtain insights into the reaction mechanism based on a series of control experiments and mass spectroscopy. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics