Month: October 2022

Related Products of 70-55-3In 2019 ,《High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides》 was published in Organic Letters. The article was written by Becica, Joseph; Hruszkewycz, Damian P.; Steves, Janelle E.; Elward, Jennifer M.; Leitch, David C.; Dobereiner, Graham E.. The article contains the following contents:

Through targeted high-throughput experimentation (HTE), authors have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chem. AdBippyPhos is particularly effective for the installation of heteroaromatic groups. Computational steric parametrization of the investigated ligands reveals the potential importance of remote steric demand, where a large cone angle combined with an accessible Pd center is correlated to successful catalysts for C-N coupling reactions. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 70-55-3In 2019 ,《Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement》 was published in Nature Communications. The article was written by Zhou, Bo; Zhang, Ying-Qi; Zhang, Kairui; Yang, Ming-Yang; Chen, Yang-Bo; Li, You; Peng, Qian; Zhu, Shou-Fei; Zhou, Qi-Lin; Ye, Long-Wu. The article contains the following contents:

Here a metal-free intramol. hydroalkoxylation/[1,3]-rearrangement was reported, leading to the practical and atom-economical assembly of valuable medium-sized lactams such as I [R1 = Me, Et, Ph; R2 = Me, Ph, 2-naphthyl, etc.; R3 = 8-Me, 9-Cl, 8-Br, etc.; R4 = SO2Ph, Ts, Bs] with wide substrate scope and excellent diastereoselectivity. Moreover, such an asym. cascade cyclization was realized by chiral Bronsted acid-catalyzed kinetic resolution In addition, antitumor activity tests revealed that that some of these medium-sized lactams displayed their bioactivity as antitumor agents against melanoma cells, esophageal cancer cells and breast cancer cells. A mechanistic rationale for the reaction was further supported by control experiments and theor. calculations The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 64479-78-3On November 1, 2018 ,《Synthesis and characterization of one, two and three-dimensional Cu(I) polymers supported by bipyridylamide ligands》 appeared in Polyhedron. The author of the article were Mugenzi, Clement; Powell, Douglas R.; Gerasimchuk, Nikolay N.; Yang, Lei. The article conveys some information:

Reaction of bipyridylamide ligands N-(3-pyridyl)nicotinamide (3-pna), N-(4-pyridyl)nicotinamide (4-pna) and N-(4-pyridyl)isonicotinamide (4-pina) with Cu(I) salts afforded four coordination polymers. The prepared complexes are [Cu(3-pna)2]SbF6 (1), [Cu(4-pna)2]SbF6 (2), [Cu(4-pina)(CH3CN)2]SbF6 (3), {[Cu2(4-pna)4](SbF6)2(H2O)}n (4), and [Cu(4-bpe)2](SbF6) (5). X-ray crystallog. anal. showed one-, two- and three-dimensional networks. The correlation between the pyridyl nitrogen donor disposition and dimensionality of the structures is discussed. Reflectance UV-visible and fluorescence spectroscopic methods were used to characterize the MLCT features of these complexes. Thermal stability of the coordination polymers under nitrogen was also studied. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application of 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 87694-50-6On October 15, 1991 ,《Conformational studies on bombesin antagonists: CD and NMR characterization of [Thr6, Leu13ψ(CH2NH)Met14] bombesin (6-14)》 was published in Biopolymers. The article was written by Di Bello, Carlo; Scatturin, Angelo; Vertuani, Gianni; D’Auria, Gabriella; Gargiulo, Mario; Paolillo, Livio; Trivellone, Enrico; Gozzini, Luigia; DeCastiglione, Roberto. The article contains the following contents:

The conformational flexibility of the [Thr6, Leu13ψ(CH2NH) Met14] bombesin (6-14) nonapeptide was studied by CD and 1- and 2-dimensional (1D and 2D) NMR techniques. The CD and NMR parameters in different solvents and in a micellar environment (SDS) are compared with the data collected for the parent bombesin (BN) and [D-Phe12, Leu14]BN. A preliminary investigation on spantide is also reported. In particular, the results obtained from CD measurements indicate that there is a shift from random coil structures, in aqueous solutions, toward folded structures in apolar media (2,2,2-trifluoroethanol) and in a membrane-mimetic environment (40 mM SDS) for all 3 peptides, namely BN, [D-Phe12, Leu14]BN, and [Thr6, Leu13ψ(CH2NH)Met14] BN (6-14). Spantide, which also possesses some inhibitory activity against BN but very little sequence similarity, even in water, shows an ordered conformation. NMR parameters such as backbone NH-α-CH coupling constant values, amidic temperature coefficients, and the presence of only sequential nuclear Overhauser effects have not provided, so far, any clear evidence for a preferential ordered structure in the peptides studied, and this may be due to rapid exchange among different conformers in the NMR time scale. In the part of experimental materials, we found many familiar compounds, such as (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Related Products of 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Related Products of 87694-50-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 87694-50-6On October 31, 2015 ,《An alternative synthetic route to (3R,5S,1’S)-5-{1′-[(tert-butoxycarbonyl)amino]-3′-methylbutyl}-3-methyldihydrofuran-2(3H)-one, a precursor of a Leu-Ala hydroxyethylene isostere》 appeared in Synthesis. The author of the article were Vila-Real, Helder; Ventura, M. Rita; Maycock, Christopher; Iranzo, Olga; Simplicio, Ana. The article conveys some information:

An improved synthetic route to (3R,5S,1’S)-5-{1′-[(tert-butoxycarbonyl)amino]-3′-methylbutyl}-3-methyldihydrofuran-2(3H)-one, a lactone precursor of the Leu-Ala (2R,4S,5S) hydroxyethylene isostere found in many peptidomimetic aspartyl protease inhibitors of Alzheimer’s disease, is devised. Alkylation of N-Boc-leucinal (Boc = tert-butyloxycarbonyl) with the lithium salt of benzyl propargyl ether instead of Et propiolate is the key toward a more reproducible and efficient route to obtain the title lactone from N-Boc-L-leucine in six steps, and an overall yield of 16%. The results came from multiple reactions, including the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Application of 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Application of 87694-50-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Miletin, Miroslav; Hartl, J.; Odlerova, Z.; Machacek, M. published an article in Pharmazie. The title of the article was 《Synthesis of some 2,6-bis(alkylthio)-4-pyridinecarboxamides and -carbothioamides and their antimycobacterial and antialgal activity》.Application of 89281-13-0 The author mentioned the following in the article:

Various 2,6-bis(alkylthio)-4-pyridinecarboxamides were prepared by treatment of 2,6-dichloro-4-pyridinecarboxamide with 1-alkanethiols. Subsequent reaction with Lawesson’s reagent gave the corresponding thioamides. The thioamides especially showed antimycobacterial activity; some of them inhibited chlorophyll production of Chlorella vulgaris. In the experiment, the researchers used 2,6-Dichloroisonicotinamide(cas: 89281-13-0Application of 89281-13-0)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 89281-13-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Saari, Walfred S.; Fischer, Thorsten E. published an article in Synthesis. The title of the article was 《A convenient and versatile synthesis of chiral aliphatic and allylic amines》.Application of 87694-50-6 The author mentioned the following in the article:

Treating (S)- and (R)-Boc-Leu-OH in EtOH containing N-methylmorpholine with ClCO2CH2CHMe2 and then with MeONHMe gave 89-99% (S)- and (R)-Boc-Leu-NMeOMe, which were reduced with LiAlH4 in THF to give 69-72% Boc-Leu-H. Wittig reaction of these aldehydes with Ph3P+CH2R Br- (R = Me, Et, Pr, Bu) and KN(SiMe3)2 in THF-PhMe gave 6 (S)- and (R)-Me2CHCH2CH(NHBoc)CH:CHR-Z [(R)-I] in 72-97% yield. I in EtOH were hydrogenated over Pd/C to give 86-99% (S)- and (R)-Me2CHCH2CH(NHBoc)CH2CH2R [(R)-II]. Deprotection of (S)-I (R = Pr) and all 6 II with dry HCl in EtOAc gave 46-93% title amine hydrochlorides. In the part of experimental materials, we found many familiar compounds, such as (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Application of 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Application of 87694-50-6 In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《PiPo: random copolymers of C- with N-substituted glycines》 were Wang, Siqi; Chen, Wanli; Ling, Jun. And the article was published in Polymer Chemistry in 2022. Application In Synthesis of H-Lys(Boc)-OH The author mentioned the following in the article:

Random copolymers of C- with N-substituted glycines (PiPo) were synthesized by carrying out a statistical copolymerization of N-phenyloxycarbonyl-C-substituted glycine (NPC) monomers with N-phenyloxycarbonyl-N-substituted glycine (NNPC) monomers. The copolymerization kinetics were analyzed in detail. The solubility of PiPo was found to highly depend on the compositions of the peptide and peptoid repeat units. The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Application In Synthesis of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application In Synthesis of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2010,Yu, Shouyun; Ishida, Hiroshi; Juarez-Garcia, M. Elisa; Bode, Jeffrey W. published 《Unified synthesis of enantiopure β2h, β3h and β2,3-amino acids》.Chemical Science published the findings.Name: tert-Butyl N,N’-diisopropylcarbamimidate The information in the text is summarized as follows:

A single chiral auxiliary and synthetic route can be used for a three-step (cycloaddition, auxiliary removal and fragmentation) preparation of enantiopure β3h, β2h and β2,3-amino acids (>99% ee). This approach works for a wide variety of both natural and unnatural side chains, provides access to either enantiomeric form, and can be executed on a preparative scale without recourse to column chromatog. After reading the article, we found that the author used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Ge, Jing-Jie; Yao, Chuan-Zhi; Wang, Mei-Mei; Zheng, Hong-Xing; Kang, Yan-Biao; Li, Yadong published 《Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)-C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes》.Organic Letters published the findings.Formula: C4H9NO2 The information in the text is summarized as follows:

A transition-metal-free deacylative C(sp3)-C(sp2) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and com. abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics