Month: October 2022

In 2019,Organic Letters included an article by Marcyk, Paul T.; Cook, Silas P.. Safety of 4-Methylbenzenesulfonamide. The article was titled 《Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes》. The information in the text is summarized as follows:

The hydrofunctionalization of alkenes, explored for over 100 years, offers the potential for a direct, atom-economical approach to value-added products. While thermodynamically favored, the kinetic barrier to such processes necessitates the use of catalysts to control selectivity and reactivity. Modern variants typically rely on noble metals that require different ligands for each class of hydrofunctionalization, thereby limiting generality. This Letter describes a general iron-based system that catalyzes the hydroamination and hydroetherification of simple unactivated olefins. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Safety of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Kinetics and mechanistic study of oxidation of paracetamol: an accelerated catalytic approach》 were Negi, Reena; Jain, Bhawana; Singh, Sunita; Singh, Ajaya Kumar; Asthana, Anupama. And the article was published in SN Applied Sciences in 2019. Quality Control of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

In the present paper, a simple, and novel method for the abatement of paracetamol (PA) in aqueous system into environmental friendly compound benzoquinone at 308 K has been described, and was accelerated by simple, and inexpensive catalyst Cu(II)/Ni(II). A comparative assessment between Cu(II) and Ni(II)catalyzed, abatement of PA by CAT was performed. It has been determined that there are very little change in rate of reaction for both Cu(II)/Ni(II) catalyzed degradation of PA. All the kinetics parameters, i.e. the effect of change in concentrations of chloramine-T (CAT), sodium hydroxide, paracetamol, catalyst, added p-toluenesulfonamide, electrolyte etc. have been studied, and measured carefully. Reaction had been studied in the range of temperature 303-323 K. On the basis of kinetic data obtained a satisfactory mechanism has been proposed. And it was deduced that, presently used process was a tenable technique for the degradation of PA. Main abatement product was confirmed by GC-MS anal. technique. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Tilby, Michael J.; Dewez, Damien F.; Pantaine, Loic R. E.; Hall, Adrian; Martinez-Lamenca, Carolina; Willis, Michael C. published an article in ACS Catalysis. The title of the article was 《Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates》.Reference of 4-Methylbenzenesulfonamide The author mentioned the following in the article:

A plethora of drug mols. and agrochems. contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates. This methodol. exploits a metal-free photocatalytic approach to access radical chem., which is harnessed by combining pharmaceutically relevant sulfonamides with an assortment of alkene fragments. Addnl., the sulfinate anion can be readily obtained, further broadening the options for sulfonamide functionalization. Mechanistic studies suggest that energy-transfer catalysis (EnT) is in operation. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: N-Methoxy-N-methylacetamideIn 2016 ,《A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives》 appeared in Tetrahedron. The author of the article were Gilbert, Eric J.; Brunskill, Andrew; Cai, Jiaqiang; Cai, Yaxian; Chu, Xin-Jie; Dai, Xing; Hao, Jinsong; Kuethe, Jeffrey T.; Lai, Zhong; Liu, Hong; Mu, Cuizhi; Qi, Yan; Scott, Jack D.; Taoka, Brandon; Truong, Quang; Walsh, Shawn P.; Wu, Wen-Lian; Cumming, Jared N.. The article conveys some information:

A novel domino reaction for the preparation of non-racemic β-proline derivatives is reported. The addition of a Me 2-(oxetan-3-yl)acetate titanium enolate to chiral tert-butanesulfinyl ketimines followed by an intramol. oxetane ring-opening provides the highly-substituted pyrrolidine ring systems with three contiguous stereogenic centers. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C2H4BrNOIn 2021 ,《Semaphorin 3A-glycosaminoglycans interaction as therapeutic target for axonal regeneration》 was published in Pharmaceuticals. The article was written by Perez, Yolanda; Bonet, Roman; Corredor, Miriam; Domingo, Cecilia; Moure, Alejandra; Messeguer, Angel; Bujons, Jordi; Alfonso, Ignacio. The article contains the following contents:

Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance mol., inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biol. relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725-771) with GAGs and to investigate the disruption of this interaction by small mols. Recombinant Sema3A basic domain was produced and we used a combination of biophys. techniques (NMR, SPR, and heparin affinity chromatog.) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by mol. dynamics simulations, show that a new peptoid mol. (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new mols. targeting these protein-GAG interactions with potential therapeutic applications. In addition to this study using 2-Bromoacetamide, there are many other studies that have used 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO) was used in this study.

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.COA of Formula: C2H4BrNO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of N-Methoxy-N-methylacetamideIn 2019 ,《Asymmetric synthesis of natural cis-dihydroarenediols using tetrahydroxynaphthalene reductase and its biosynthetic implications》 was published in Organic Letters. The article was written by Saha, Nirmal; Muller, Michael; Husain, Syed Masood. The article contains the following contents:

Asym. reduction of hydroxynaphthoquinones to secondary metabolites, (3S,4R)-3,4,8- and (2S,4R)-2,4,8-trihydroxy-1-tetralone, a putative biosynthetic diketo intermediate and a probable natural analog, (3S,4R)-7-acetyl-3,4,8-trihydroxy-6-methyl-3,4-dihydronaphthalene-1(2H)-one, using NADPH-dependent tetrahydroxynaphthalene reductase (T4HNR) of Magnaporthe grisea is described. This work implies the involvement of T4HNR or related enzymes during the (bio)synthesis of other dihydroarenediols by reduction of the hydroxynaphthoquinone scaffold containing substrates. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Reference of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets》 was written by Salari, Hassan; Duronio, Vincent; Howard, Sandra L.; Demos, Michelle; Jones, Kelvin; Reany, Anne; Hudson, Alan T.; Pelech, Steven L.. Application of 106392-48-7 And the article was included in FEBS Letters on April 9 ,1990. The article conveys some information:

The role of protein-tyrosine phosphorylation in the signal transduction of platelet activating factor (PAF) was investigated in rabbit platelets with a range of synthetic compounds that inhibit protein-tyrosine kinases. In particular, erbstatin (IC50 ∼ 20 μg/mL) abrogated a wide range of platelet responses to PAF, including tyrosine phosphorylation of cellular proteins, polyphosphoinositide turnover, activation of membranous protein kinase C, platelet aggregation, and serotonin secretion. With about a third of the potency of erbstatin, compound RG50864 also inhibited many of these responses, whereas at 100 μg/mL, genistein, 670C88 and ST271 were without effect. Finally, the ability of thrombin to cause platelet aggregation and serotonin secretion was also compromised by erbstatin.2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7Application of 106392-48-7) was used in this study.

2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides.Application of 106392-48-7 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Room temperature C(sp2)-H oxidative chlorination via photoredox catalysis》 was published in Chemical Science in 2017. These research results belong to Zhang, Lei; Hu, Xile. HPLC of Formula: 247170-19-0 The article mentions the following:

Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp2)-H bonds over C(sp3)-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug. After reading the article, we found that the author used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0HPLC of Formula: 247170-19-0)

N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.HPLC of Formula: 247170-19-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn May 2, 2009 ,《Formation of new 4-isocyanobut-2-enenitriles by thermal ring cleavage of 3-pyridyl azides》 appeared in Tetrahedron. The author of the article were Stockmann, Vegar; Bakke, Jan M.; Bruheim, Per; Fiksdahl, Anne. The article conveys some information:

A new thermal ring cleavage of 3-pyridyl nitrenes for the formation of 4-isocyanobut-2-enenitrile products is reported. Thermolysis of 4-(thien-3-yl)-3-pyridyl azide and 3-azido-4-(1-TIPS-1H-pyrrol-3-yl)pyridine afforded two new isonitrile-nitrile products by ring cleavage; 4-isocyano-2-(thiophen-3-yl)but-2-enenitrile (I, 27%) and 4-isocyano-2-(1-TIPS-1H-pyrrol-3-yl)but-2-enenitrile (II, 20%), in addition to the previously reported pyrido[3,4-b]thienopyrrole (29%) and pyrido[3,4-b]pyrrolo[3,2-d]pyrrole (71%) products. Minor amounts of 2-(thien-3-yl)-1H-pyrrole-3-carbonitrile (III, 6%), formed by ring contraction, were also isolated after thermolysis of 4-(thien-3-yl)-3-pyridyl azide. Isonitriles I and II underwent degradation into amine and formamide, resp., by acidic hydrolysis. The nature and chem. of compounds I, III and II were investigated.2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C10H14N2OOn March 15, 2011, Metro, Thomas-Xavier; Fayet, Christine; Arnaud, Florian; Rameix, Nathalie; Fraisse, Pierre; Janody, Simon; Sevrin, Mireille; George, Pascal; Vogel, Rachel published an article in Synlett. The article was 《Synthesis of 2,2-disubstituted azaindolines by intramolecular cyclization in acidic media》. The article mentions the following:

The synthesis of a diverse array of 2,2-disubstituted azaindolines, e.g. I, is reported. The bicyclic core is built by a simple acidic treatment of conveniently substituted aminopyridines. The results came from multiple reactions, including the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Synthetic Route of C10H14N2O)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C10H14N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics