Month: October 2022

《Stereoselective organo-catalyzed glycosylation – thiouracil, thioureas and mono-thio-phthalimide act as Bronsted acid catalysts at low loadings》 was written by Bradshaw, G. A.; Colgan, A. C.; Allen, N. P.; Pongener, I.; Boland, M. B.; Ortin, Y.; McGarrigle, E. M.. Synthetic Route of C7H9NO2SThis research focused ontrehalose disaccharide synthesis stereoselective glycosylation catalyst Schreiner thiourea; hydrogen bonding Bronsted acid base catalysis deoxyglycoside glycoconjugate synthesis; stereoselective glycosylation catalyst galactal thiouracil thiophthalimide amino acid. The article conveys some information:

Thiouracil catalyzes stereoselective glycosylations with galactals in loadings as low as 0.1 mol%. It is proposed that in these glycosylation thiouracil, monothiophthalimide, and the previously reported catalyst, Schreiner′s thiourea, do not operate via a double H-bonding mechanism but rather by Bronsted acid/base catalysis. In addition to the synthesis of 2-deoxyglycosides and glycoconjugates, we report the first organo-catalytic synthesis of 1,1′-linked trehalose-type sugars.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Trans-Selective hydrocyanation of ynoates, ynones and ynoic acids catalyzed by nucleophilic phosphines》 was written by Schoemberg, Fritz; Peric, Milica; Meyer, Maximilian; Vilotijevic, Ivan. Formula: C4H9NO2This research focused ontrimethylsilyl cyanide phenyl propynoate methyldiphenylphosphine catalyst diastereoselective hydrocyanation; cyano phenyl acrylate regioselective preparation; trimethylsilanecarbonitrile phenyl propynoic acid methyldiphenylphosphine catalyst diastereoselective hydrocyanation; phenyl cyano acrylic acid regioselective preparation. The article conveys some information:

Trans-Selective hydrocyanation of ynoates and ynones in the presence of TMSCN and an alc. additive were catalyzed by nucleophilic phosphines. The trisubstituted E-olefin products of anti-addition of hydrogen cyanide to the alkyne were produced with high regio- and stereoselectivity. The alc. additive reacts with TMSCN to produce hydrogen cyanide in situ. Ynoic acids underwent the phosphine catalyzed hydrocyanation in the presence of TMSCN under aprotic conditions only. In these reactions, TMSCN reacted with the acid to generate hydrogen cyanide and the silyl ester which, unlike the acid, undergoes phosphine catalyzed hydrocyanation and gave the stereo-defined E-2-cyano-acrylic acids after work up.N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Unexpected right-handed helical nanostructures co-assembled from L-phenylalanine derivatives and achiral bipyridines》 was published in Chemical Science in 2017. These research results belong to Liu, Guofeng; Liu, Jinying; Feng, Chuanliang; Zhao, Yanli. Application of 64479-78-3 The article mentions the following:

The construction of chiral supramol. systems with desirable handedness is of great importance in materials science, chem., and biol. since chiral nanostructures exhibit fascinating photophys. properties and unique biol. effects. Herein, we report that achiral bipyridines can co-assemble with L-phenylalanine derivatives into unexpected right-handed helical nanostructures rather than a left-handed helix via intermol. hydrogen bonding interactions formed between the pyridyl and carboxylic groups. This study opens up a route to develop chiral nanostructures with desirable handedness via the co-assembly of simple mol. building blocks and provides a straightforward insight into the chirality control of nanostructures in supramol. systems. In addition to this study using N-(Pyridin-4-yl)isonicotinamide, there are many other studies that have used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application of 64479-78-3) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Application of 64479-78-3 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 2-Hydroxy-N-phenylacetamideOn May 31, 2008, Gomez, Maria J.; Sirtori, Carla; Mezcua, Milagros; Fernandez-Alba, Amadeo R.; Agueera, Ana published an article in Water Research. The article was 《Photodegradation study of three dipyrone metabolites in various water systems: Identification and toxicity of their photodegradation products》. The article mentions the following:

The photochem. behavior of 3 relevant metabolites of the analgesic and antipyretic drug dipyrone, 4-methylaminoantipyrine (4-MAA), 4-formylaminoantipyrine (4-FAA) and 4-acetylaminoantipyrine (4-AAA), was evaluated under simulated solar irradiation (Suntest system). For 4-MAA, different aqueous solutions (synthetic seawater, freshwater and Milli-Q water) as well as different operational conditions were compared. According to the exptl. results, 4-MAA resulted as being an easily degraded mol. by direct photolysis, with half-life times (t1/2) ranging from 0.12 to 0.58 h, depending on the irradiation conditions. Faster degradation was observed in synthetic waters, suggesting that the photolysis was influenced by the salt composition of the waters. However, no effect on the degradation rate was observed by the presence of natural photosensitizers (dissolved organic matter, nitrate ions). 4-FAA and 4-AAA showed slower photodegradation kinetics, with t1/2 of 24 and 28 h, resp. A study of photoproduct identification was carried out by gas chromatog.-mass spectrometry (GC-MS) and liquid chromatog.-time-of-flight mass spectrometry (LC-TOF-MS) (ESI pos. mode), which allowed us to propose a tentative photodegradation pathway for 4-MAA and the identification of persistent byproducts in all the cases. The application of an acute toxicity test (Daphnia magna) showed an increase in toxicity during the photolytic process, a consequence of the formation of toxic photoproducts. The results came from multiple reactions, including the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocksOn September 16, 2016 ,《Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids》 was published in Organic Letters. The article was written by Zhu, Yan-Ping; Sergeyev, Sergey; Franck, Philippe; Orru, Romano V. A.; Maes, Bert U. W.. The article contains the following contents:

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with com. reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols. In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Category: amides-buliding-blocks)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gaskin, Gabrielle J.; LaDuca, Robert L. published an article in IUCrData. The title of the article was 《Poly[diaqua[μ4-2-(carboxylatomethoxy)benzoato][μ2-2-(carboxylatomethoxy)benzoato]dicadmium(II)]》.Electric Literature of C11H9N3O The author mentioned the following in the article:

In the title compound, [Cd2(C9H6O5)2(H2O)2]n, the crystallog. distinct CdII cations are coordinated in pentagonal-bipyramidal and octahedral fashions. The 2-(carboxymethoxy)benzoate (cmb) ligands connect the Cd atoms into [Cd2(cmb)2(H2O)2)]n coordination polymer ribbons that are oriented along the a-axis direction. Supramol. layers are formed parallel to (01 [inline formula omitted] ) by O-H···O hydrogen bonding between the ribbons. The supramol. three-dimensional crystal structure of the title compound is then constructed by π-π stacking interactions with a centroid-centroid distance of 3.622 (2) Å between cmb ligands in adjacent layer motifs. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Electric Literature of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Electric Literature of C11H9N3OAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2012,ChemBioChem included an article by Pereira, Alban R.; Kale, Andrew J.; Fenley, Andrew T.; Byrum, Tara; Debonsi, Hosana M.; Gilson, Michael K.; Valeriote, Frederick A.; Moore, Bradley S.; Gerwick, William H.. Recommanded Product: 87694-50-6. The article was titled 《The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium》. The information in the text is summarized as follows:

Two new peptidic proteasome inhibitors were isolated as trace components from a Curacao collection of the marine cyanobacterium Symploca sp. Carmaphycin A (1) and carmaphycin B (2) feature a leucine-derived α,β-epoxyketone warhead directly connected to either methionine sulfoxide or methionine sulfone. Their structures were elucidated on the basis of extensive NMR and MS analyses and confirmed by total synthesis, which in turn provided more material for further biol. evaluations. Pure carmaphycins A and B were found to inhibit the β5 subunit (chymotrypsin-like activity) of the S. cerevisiae 20S proteasome in the low nanomolar range. Addnl., they exhibited strong cytotoxicity to lung and colon cancer cell lines, as well as exquisite antiproliferative effects in the NCI60 cell-line panel. These assay results as well as initial structural biol. studies suggest a distinctive binding mode for these new inhibitors. The experimental process involved the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Recommanded Product: 87694-50-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《N-tert-Butoxycarbonyl-L-leucinal (carbamic acid, (1-formyl-3-methylbutyl)-, 1,1-dimethylethyl ester, (S)-)》 were Goel, O. P.; Krolls, U.; Stier, M.; Kesten, S.. And the article was published in Organic Syntheses in 1989. Related Products of 87694-50-6 The author mentioned the following in the article:

The title compound, Boc-Leu-H (Boc = Me3CO2C), was prepared from Boc-Leu-OH via LiAlH4 reduction of Boc-Leu-NMeOMe. The results came from multiple reactions, including the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Related Products of 87694-50-6)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Related Products of 87694-50-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Volpi, Stefano; Rozzi, Andrea; Rivi, Nicola; Neri, Martina; Knoll, Wolfgang; Corradini, Roberto published an article on February 5 ,2021. The article was titled 《Submonomeric strategy with minimal protection for the synthesis of C(2)-modified peptide nucleic acids》, and you may find the article in Organic Letters.Application In Synthesis of H-Lys(Boc)-OH The information in the text is summarized as follows:

A novel synthesis of C(2)-modified peptide nucleic acids (PNAs) is proposed, using a submonomeric strategy with minimally protected building blocks, which allowed a reduction in the required synthetic steps. N(3)-unprotected, D-Lys- and D-Arg-based backbones were used to obtain pos. charged PNAs with high optical purity, as inferred from chiral GC measurements. “”Chiral-box”” PNAs targeting the G12D point mutation of the KRAS gene were produced using this method, showing improved sequence selectivity for the mutated- vs wild-type DNA strand with respect to unmodified PNAs. The experimental part of the paper was very detailed, including the reaction process of H-Lys(Boc)-OH(cas: 2418-95-3Application In Synthesis of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application In Synthesis of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2014,Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Inai, Makoto; Hamashima, Yoshitaka; Kan, Toshiyuki published 《Practical Total Syntheses of Acromelic Acids A and B》.Organic Letters published the findings.Product Details of 71432-55-8 The information in the text is summarized as follows:

Practical total syntheses of acromelic acids A (I) and B (II), which have potent neuro-excitatory activity, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), resp., from 2,6-dichloropyridine. Regioselective transformation of sym. 2,6-dichloropyridine provided nitroalkenes III and IV. The pyrrolidine ring was efficiently constructed by Ni-catalyzed asym. conjugate addition followed by intramol. reductive amination. In the experiment, the researchers used many compounds, for example, tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Product Details of 71432-55-8)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics