Month: October 2022

In 2019,Organic Chemistry Frontiers included an article by Qi, Jifeng; Tang, Haibin; Chen, Changwei; Cui, Sunliang; Xu, Gang. Computed Properties of C7H9NO2S. The article was titled 《Reductive coupling of alkenes with unsaturated imines via a radical pathway》. The information in the text is summarized as follows:

The reductive coupling of unsaturated imines with alkenes via a radical pathway was reported. Various unsaturated imines and alkenes delivered structurally diversified benzofurans, benzothiophenes and medium-sized benzofuran-fused heterocycles. The protocol features mild reaction conditions and broad substrate scope. In addition to this study using 4-Methylbenzenesulfonamide, there are many other studies that have used 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S) was used in this study.

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Iodoamination of Alkenyl Sulfonamides by Potassium Iodide and Hydrogen Peroxide in Aqueous Medium》 were Giofre, Sabrina; Sala, Roberto; Beccalli, Egle Maria; Presti, Leonardo Lo; Broggini, Gianluigi. And the article was published in Helvetica Chimica Acta in 2019. Electric Literature of C7H9NO2S The author mentioned the following in the article:

A procedure for the iodoamination of unfunctionalized olefins tethered to a tosyl-protected NH-group has been developed. The combined use of KI and H2O2 in aqueous medium was effective for the preparation of iodomethyl-substituted nitrogen-containing heterocycles. The selective exo-trig iodocyclization provided 1,2-bifunctional 5-, 6-, and 7-membered cyclic skeletons. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 71432-55-8In 2020 ,《Sevanol and its analogues: chemical synthesis, biological effects and molecular docking》 was published in Pharmaceuticals. The article was written by Belozerova, Olga A.; Osmakov, Dmitry I.; Vladimirov, Andrey; Koshelev, Sergey G.; Chugunov, Anton O.; Andreev, Yaroslav A.; Palikov, Victor A.; Palikova, Yulia A.; Shaykhutdinova, Elvira R.; Gvozd, Artem N.; Dyachenko, Igor A.; Efremov, Roman G.; Kublitski, Vadim S.; Kozlov, Sergey A.. The article contains the following contents:

In this work, the efficient chem. synthesis scheme of sevanol I [R = H] and its analogs I [R = Me], II and III which allowed us to analyze the structure-activity relationships of the different parts of this mol. was described. We found that the inhibitory activity of sevanol and its analogs on ASIC1a and ASIC3 channels depends on the number and availability of the carboxyl groups of the mol. At the structural level, it was predicted the presence of a sevanol binding site based on the presence of mol. docking in the central vestibule of the ASIC1a channel. Also it was predicted that this site could also be occupied in part by the FRRF-amide peptide, and the competition assay of sevanol with this peptide confirmed this prediction. The i.v. (i.v.), intranasal (i.n.) and, especially, oral (p.o.) administration of synthetic sevanol in animal models produced significant analgesic and anti-inflammatory effects. Both non-invasive methods of sevanol administration (i.n. and p.o.) showed greater efficacy than the invasive (i.v.) method, thus opening new horizons for medicinal uses of sevanol. In addition to this study using tert-Butyl N,N’-diisopropylcarbamimidate, there are many other studies that have used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Related Products of 71432-55-8) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: tert-Butyl N,N’-diisopropylcarbamimidateIn 2020 ,《Total Synthesis of (+)-Trachyspic Acid 19-n-Butyl Ester》 was published in Organic Letters. The article was written by Rafaniello, Alex A.; Rizzacasa, Mark A.. The article contains the following contents:

The first total synthesis of the alkyl citrate trachyspic acid 19-Bu ester (I) is described. A formal [2 + 2]-cycloaddition of the silylketene acetal derived from lactone II with di-n-butylacetylenedicarboxylate provided the cyclobutene diester III with a dr >20:1. Acid-mediated rearrangement of III followed by lactone ring-opening and ester protecting group manipulation eventually provided orthogonally protected aldehyde IV. A Nozaki-Hiyama-Kishi coupling between IV and vinyl iodide V followed by oxidation of the resultant allylic alc. gave an enone, which was converted into a triester (dr 6:1) by a spirocyclization/oxidative cleavage/elimination sequence. Removal of the t-Bu esters then afforded trachyspic acid 19-Bu ester I. In the experimental materials used by the author, we found tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: tert-Butyl N,N’-diisopropylcarbamimidate

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 70-55-3In 2020 ,《Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines》 was published in Journal of Organic Chemistry. The article was written by Gou, Quan; Liu, Zining; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man; Cheng, Feixiang; Qin, Jun. The article contains the following contents:

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.HPLC of Formula: 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Preparation of Primary Amides from Functionalized Organozinc Halides》 was written by Schade, Matthias A.; Manolikakes, Georg; Knochel, Paul. Quality Control of 2,6-Dichloroisonicotinamide And the article was included in Organic Letters on August 20 ,2010. The article conveys some information:

Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with com. available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dichloroisonicotinamide(cas: 89281-13-0Quality Control of 2,6-Dichloroisonicotinamide)

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Quality Control of 2,6-Dichloroisonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamideOn March 1, 1994, Laneuville, Pierre; Timm, Martina; Hudson, Alan T. published an article in Cancer Research. The article was 《Bcr/abl expression in 32D cl3(G) cells inhibits apoptosis induced by protein tyrosine kinase inhibitors》. The article mentions the following:

Eight protein tyrosine kinase inhibitors with in vitro epidermal growth factor receptor kinase 50% inhibitory concentration values ranging from 0.043 to 22 μM were studied for their ability to inhibit the growth of the murine interleukin-3 (IL-3) dependent myeloid 32D cl3(G) cell line, and a subclone (LG7) transformed to IL-3 independent growth by retroviral transduction and expression of the chronic myelogenous leukemia-associated protein tyrosine kinase p210bcr/abl. Cell proliferation 50% inhibitory concentration values ranged from 4 to 250 μM, and one compound was not inhibitory at 500 μM. The dose-cell proliferation curves were remarkably similar for parental 32D cl3(G) cells + IL-3 and LG7 ± IL-3, and reversion of LG7 cells to IL-3 dependence was not observed, suggesting that none of the compounds tested could selectively inhibit p21bcr/abl. However, 6 compounds induced the appearance of a 200-base pair nucleosomal DNA ladder characteristic of apoptosis at 24 h in parental 32D cl3(G) cells + IL-3, which mimicked the effects of IL-3 withdrawal alone, but not in similarly growth arrested LG7 cells that eventually developed a necrotic pattern of DNA fragmentation. These studies suggest that the expression of p210bcr/abl can suppress apoptotic signal transduction and that this may contribute to the development of the myeloid hyperplasia that occurs in chronic phase chronic myelogenous leukemia.2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7Quality Control of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide) was used in this study.

2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Quality Control of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of C11H22N2O4On June 3, 2019, Zhu, Yongyan; Liu, Ruixuan; Huang, Haoji; Zhu, Quanhong published an article in Molecular Pharmaceutics. The article was 《Vinblastine-Loaded Nanoparticles with Enhanced Tumor-Targeting Efficiency and Decreasing Toxicity: Developed by One-Step Molecular Imprinting Process》. The article mentions the following:

Molecularly imprinted polymers have exhibited good performance as carriers on drug loading and sustained release. In this paper, vinblastine (VBL)-loaded polymeric nanoparticles (VBL-NPs) were prepared by a one-step mol. imprinting process, avoiding the waste and incomplete removal of the template, and evaluated as targeting carriers for VBL delivery after modification. Using acryloyl amino acid comonomers and disulfide cross-linkers, VBL-NPs were synthesized and then conjugated with poly(ethylene glycol)-folate. The dynamic size of the obtained VBL-NPs-PEG-FA was 258.3 nm (PDI = 0.250), and the encapsulation efficiency was 45.82 ± 1.45%. The nanoparticles of VBL-NPs-PEG-FA were able to completely release VBL during 48 h under a mimic tumor intracellular condition (pH 4.5, 10 mM glutathione (GSH)), displaying significant redox responsiveness, whereas the release rates were much slower in the mimic body liquid (pH 7.4, 2μM GSH) and tumor extracellular environment (pH 6.5, 2μM GSH). Furthermore, the carriers NPs-PEG-FA, prepared without VBL, showed satisfactory intrinsic hemocompatibility, cellular compatibility, and tumor-targeting properties: they could rapidly and efficiently accumulate to folate receptor pos. Hela cells and then internalized via receptor-mediated endocytosis, and the retention in tumor tissues could last for over 48 h. Interestingly, VBL-NPs-PEG-FA could evidently increase the accumulation of VBL in tumor tissues while decreasing the distribution of VBL in organs, exert similar anticancer efficacy against Hela tumors in the xenograft model of nude mice to VBL injection, and significantly improve the abnormality of liver and spleen observed in VBL injection. VBL-NPs-PEG-FA has the potential to be the delivery carrier for VBL by enhancing the tumor-targeting efficacy of VBL and decreasing toxicity to normal tissues. The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Electric Literature of C11H22N2O4)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Electric Literature of C11H22N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ross, Tamsyn M.; Neville, Suzanne M.; Innes, David S.; Turner, David R.; Moubaraki, Boujemaa; Murray, Keith S. published an article on January 7 ,2010. The article was titled 《Spin crossover in iron(III) Schiff-base 1-D chain complexes》, and you may find the article in Dalton Transactions.Formula: C11H9N3O The information in the text is summarized as follows:

Iron(III) 1-dimensional polymeric materials, [Fe(III)(Schiff-base)(L)](BPh4).n(CH3OH) (Schiff base = N,N’-ethylenebis(salicylaldimine) (H2salen), N,N’-o-phenylenebis(salicylaldimine) (H2salophen) and N,N’-ethylenebis(acetylacetonimine) (H2acen); L = bridging di-pyridyl or di-imidazole ligand, n = 0-4) and analogs therein, were synthesized and structurally and magnetically characterized. In this series, a range of structural motifs are observed including linear 1-dimensional chains, hydrogen-bonded chains, a ‘hybrid’ 1-dimensional chain-and -dimer compound and a hydrogen-bonded dinuclear material; all exhibit extensive intermol. interactions. The magnetic consequences of varying both the equatorial Schiff-base ligands and axial bridging ligands were studied. Overall, independent of the axial bridging ligand employed, the salen equatorial ligand results in a high spin character and the acen ligand results in spin crossover character, generally with a spin transition of a gradual nature. Variations in magnetic behavior can be rationalized, in part, in terms of the C2N2 backbone conformation of the equatorial Schiff base ligand, which may either inhibit or allow a spin transition. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Formula: C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Formula: C11H9N3O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Russian Chemical Bulletin included an article by Krylov, E. N.; Virzum, L. V.. Quality Control of 4-Methylbenzenesulfonamide. The article was titled 《Acidity of arylsulfonamides as function of quantum chemical parameters of sulfonamide nitrogen》. The information in the text is summarized as follows:

The structures of aromatic sulfonamide mols. XPhSO2NH2 (X = H, 4-Me, 4-F, 4-Cl, 4-Br, 4-MeO, 4-OH, 4-NH2, 4-CN, 3-NO2, 4-NO2, 3,5-(NO2)2, 3,4-Cl2, 3-Cl-4-Me, 3,4-Me2, 3-Me-4-F, 2-Me) were calculated at the M06/6-311++G** (SMD) level of theory. The at. electrostatic potentials (AEP) and the Hirshfeld charges of the sulfonamide nitrogen atoms were determined Correlation equations relating the AEP to Bronsted acidities (pKa) of these compounds were obtained using published data and the previously unknown pKa values for a number of arylsulfonamides were calculated These pKa values are consistent with independently determined free energies of acid dissociation of sulfonamides. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics