Month: October 2022

HPLC of Formula: 106392-48-7On October 3, 1994 ,《Phosphorylation of JAK2 in thrombin-stimulated human platelets》 was published in FEBS Letters. The article was written by Rodriguez-Linares, Belen; Watson, Steve P.. The article contains the following contents:

We show the presence of the tyrosine kinase JAK2 in human platelets and demonstrate that it undergoes phosphorylation on tyrosine residues on challenge with the G protein receptor stimulus, thrombin, or the tyrosine phosphatase inhibitor, peroxovanadate. Thrombin-induced phosphorylation of JAK2 is inhibited by two structurally distinct inhibitors of tyrosine kinases, staurosporine and the tyrphostin ST271. The protein kinase C (PKC) inhibitor, Ro 31-8220, and intracellular Ca2+ chelator, BAPTA-AM, also inhibit thrombin-induced phosphorylation of JAK2, while the phorbol ester, phorbol dibutyrate (PDBu), and Ca2+ ionophore, A23187, induce tyrosine phosphorylation of JAK2. These results suggest that tyrosine phosphorylation of JAK2 stimulated by thrombin may be mediated downstream of phosphoinositide metabolism In the experiment, the researchers used many compounds, for example, 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7HPLC of Formula: 106392-48-7)

2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides.HPLC of Formula: 106392-48-7Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 70298-88-3On June 10, 1988, Estel, L.; Marsais, F.; Queguiner, G. published an article in Journal of Organic Chemistry. The article was 《Metalation/SRN1 coupling in heterocyclic synthesis. A convenient methodology for ring functionalization》. The article mentions the following:

Sequential lithiation and iodination of 2-fluoropyridine gave 85% 2-fluoro-3-iodopyridine, which underwent nucleophilic aromatic substitution with NaOMe, NH3, and MeNH2 to give 70-96% 2-substituted 3-iodopyridines I (R = iodo; R1 = OMe, NH2, NHMe). Radical nucleophilic substitution reactions of these compounds with the enolates of MeCOCMe3 or Me2CO gave pyridylmethyl ketones I (R = CH2COCMe3, CH2COMe; same R1). Intramol. cyclocondensation of I (R = CH2COCMe3, CH2COMe; R1 = NH2, NHMe) gave pyrrolo[2,3-b]pyridines II (R2 = H, Me; R3 = CMe3, Me). Similar iodination, radical nucleophilic enolate substitution, and cyclocondensation starting from 2-, 3-, and 4-(pivaloylamino)pyridines gave 2-substituted pyrrolo[2,3-b]-, -[2,3-c]-, and -[3,2-c]pyridines [e.g., II (R2 = H, R3 = CMe3, Me), III]. The experimental part of the paper was very detailed, including the reaction process of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C13H26N2O4On October 27, 1992 ,《Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease》 was published in Biochemistry. The article was written by Tomaszek, Thaddeus A. Jr.; Moore, Michael L.; Strickler, James E.; Sanchez, Robert L.; Dixon, J. Scott; Metcalf, Brian W.; Hassell, Anne; Dreyer, Geoffrey B.; Brooks, Isobel. The article contains the following contents:

Muscle and heart lactate dehydrogenases (LDHs) of rabbit and pig are specifically cleaved at a single position by HIV-1 protease, resulting in the conversion of 36-kDa subunits of the oligomeric enzymes into 21- and 15-kDa protein bands as analyzed by SDS-PAGE. While the proteolysis was observed at neutral pH, it became more pronounced at pH 6.0 and 5.0. The time courses of the cleavage of the 36-kDa subunits were commensurate with the time-dependent loss of both quaternary structure and enzymic activity. These results demonstrated that deoligomerization of rabbit muscle LDH at acidic pH rendered its subunits more susceptible to proteolysis, suggesting that a partially denatured form of the enzyme was the actual substrate. Proteolytic cleavage of the rabbit muscle enzyme occurred at a decapeptide sequence, His-Gly-Trp-Ile-Leu*Gly-Glu-His-Gly-Asp (scissile bond denoted throughout by an asterisk), which constitutes a strand-loop element in the muscle and heart LDH structures and contains the active site histidyl residue His-193. The kinetic parameters Km, Vmax/KmEt, and Vmax/Et for rabbit muscle LDH and the synthetic decapeptide Ac-His-Gly-Trp-Ile-Leu*Gly-Glu-His-Gly-Asp-NH2 were nearly identical, suggesting that the decapeptide within the protein substrate is conformationally mobile, as would be expected for the peptide substrate in solution Insertion of part of this decapeptide sequence into bacterial galactokinase likewise rendered this protein susceptible to proteolysis by HIV-1 protease, and site-directed mutagenesis of this peptide in galactokinase revealed that the Glu residue at the P2′ was important to binding to HIV-1 protease. Crystallog. anal. of HIV-1 protease complexed with a tight-binding peptide analog inhibitor derived from this decapeptide sequence revealed that the strand-loop structure of the protein substrate must adopt a β-sheet structure upon binding to the protease. The Glu residue in the P2′ position of the inhibitor likely forms hydrogen-bonding interactions with both the α-amide and γ-carboxylic groups of Asp-30 in the substrate-binding site. In the experiment, the researchers used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Formula: C13H26N2O4)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Formula: C13H26N2O4 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2020,Future Medicinal Chemistry included an article by Cao, Yucheng; Ni, Jingxuan; Ji, Wentao; Shang, Kangle; Liang, Kaicheng; Lu, Jing; Bi, Yi; Luo, Xiaomin. Recommanded Product: 2418-95-3. The article was titled 《Synthesis, antifungal activity and potential mechanism of fusidic acid derivatives possessing amino-terminal groups》. The information in the text is summarized as follows:

Aim: Fusidic acid (FA) is a narrow-spectrum bacteriostatic antibiotic. We inadvertently discovered that a FA derivative modified by an amino-terminal group at the 3-OH position, namely 2, inhibited the growth of Cryptococcus neoformans. Methods & results: Multiscale mol. modeling approaches were used to analyze the binding modes of 2 with eEF2. FA derivatives modified at the 3-OH position were designed based on in silico models; seven derivatives possessing different amino-terminal groups were synthesized and tested in vitro for antifungal activity against C. neoformans. Conclusion: Compound 7 had the strongest min. inhibitory concentration Two protonated nitrogen atoms of 7 interacted with a neg. electrostatic pocket of eEF2 likely explain the superiority of 7-2. In the part of experimental materials, we found many familiar compounds, such as H-Lys(Boc)-OH(cas: 2418-95-3Recommanded Product: 2418-95-3)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Recommanded Product: 2418-95-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Oxidation of acetanilides to glycolanilides and oxanilic acids in rabbits》 were Kiese, Manfred; Lenk, Werner. And the article was published in Biochemical Pharmacology in 1969. Recommanded Product: 4746-61-6 The author mentioned the following in the article:

In the urine of rabbits injected with various acetanilides, the corresponding glycol-anilides were found. Approx. 5% of the given acetanilides appeared in the urine as 4-chloroglycolanilide, 4-bromoglycolanilide and 4-propionylglycolanilide. They were isolated and their structures were established by uv, ir and N.M.R. spectra. Less than 1% of acetanilide and phenacetin were excreted as glycolanilides. No 4-propylglycolanilide was found in the urine after the administration of 4-propylacetanilide. The effect of various substituents in the 4-position on the biochem. hydroxylation of AcOH in acetanilides is discussed. Rabbits given 4-chloroacetanilide or 4-propionylacetanilide excrete several per cent as the corresponding oxanilic acids. In addition to this study using 2-Hydroxy-N-phenylacetamide, there are many other studies that have used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 4746-61-6) was used in this study.

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Recommanded Product: 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tyrrell, Elizabeth; Brawn, Peter; Carew, Mark; Greenwood, Iain published an article on January 19 ,2011. The article was titled 《An expedient conversion of α-amino acids into Weinreb amides using COMU as a coupling agent》, and you may find the article in Tetrahedron Letters.Electric Literature of C13H26N2O4 The information in the text is summarized as follows:

The use of COMU, as a non-hazardous partner, in the coupling of N-Boc α-amino acids with N-methoxy-N-methylamine to afford the corresponding Weinreb amides is discussed. From a practical point of view the reaction can be monitored visually by virtue of the color change associated with the conversion of substrates (yellow) into the products (orange). As the byproducts of the reaction are conveniently water-soluble, the products are isolated relatively pure and with minimal racemization. These factors coupled with the short reaction time make this a very useful procedure. In the experiment, the researchers used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Electric Literature of C13H26N2O4)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Electric Literature of C13H26N2O4 In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Targeted Synthesis of Trimeric Organic-Bromoplumbate Hybrids That Display Intrinsic, Highly Stokes-Shifted, Broadband Emission》 was written by Febriansyah, Benny; Neo, Chong Shern Daniel; Giovanni, David; Srivastava, Shivani; Lekina, Yulia; Koh, Teck Ming; Li, Yongxin; Shen, Ze Xiang; Asta, Mark; Sum, Tze Chien; Mathews, Nripan; England, Jason. Name: 2-Bromoacetamide And the article was included in Chemistry of Materials in 2020. The article conveys some information:

Zero-dimensional (0D) hybrid organic-inorganic lead halides have been shown to display efficient broadband photoluminescence and are, therefore, of significant interest for artificial lighting applications. However, work that investigates the formability of the materials as a function of templating organic cation structure are rare. This severely limits our ability to rationally design new materials displaying specific structural and photophys. properties. With the goal of accessing rare 0D trimeric bromoplumbates, we have systematically varied templating N-alkylpyridinium cations and examined their impact upon inorganic lattice structure. Whereas comparatively short and flexible N-alkyl substituents (Et, 2-hydroxyethyl, and pentyl) yield one-dimensional (1D) inorganic chains, more rigid substituents (benzyl, acetamidyl, and cyanomethyl) afford hybrids composed of lead-bromide face-sharing trimers ([Pb3Br12]6-). Of the rigid substituents studied, benzyl groups were found to enforce the highest level of distortion of the [PbBr6]4- octahedra that comprise their trimeric structures. Upon exposure to ultra-violet (UV) light, N-benzylpyridinium lead-bromide (1)6[Pb3Br12] exhibits a broadband emission, centered at 571 nm, which spans from 400 to 800 nm. More specifically, it displays a large Stokes shift of ca. 1.39 eV and a full width at half maximum (FWHM) of ca. 146 nm. This broadband emission decays with a comparatively long lifetime of 426 ns at room temperature, which increases to 5.8μs at 77 K. The reduced size and dimensionality of its inorganic lattice also results in a photoluminescence quantum yield (at least 10%) that is approx. one order magnitude higher than that of its 1D congeners. Mechanistically, broadband emission in (1)6[Pb3Br12] is believed to originate from triplet excited state(s) obtained from excited-state structural reorganization of the [Pb3Br12]6- moiety. In the experimental materials used by the author, we found 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Yang; Liu, Jian; Kamounah, Fadhil S.; Ciancaleoni, Gianluca; Lee, Ji-Woong published their research in Journal of Organic Chemistry in 2021. The article was titled 《A CO2-Catalyzed Transamidation Reaction》.SDS of cas: 78191-00-1 The article contains the following contents:

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Herein, a report on the use of CO2 as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular, N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation vs. a N2 atmosphere. Comparative Hammett studies and kinetic anal. were conducted to elucidate the catalytic activation mechanism of mol. CO2, which was supported by DFT calculations The pos. effect of CO2 in the transamidation reaction was attributed to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.SDS of cas: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Jiaxin; Wei, Yin; Shi, Min published an article in 2021. The article was titled 《Visible light mediated synthesis of 4-aryl-1,2-dihydronaphthalene derivatives via single-electron oxidation or MHAT from methylenecyclopropanes》, and you may find the article in Organic Chemistry Frontiers.Computed Properties of C4H9NO2 The information in the text is summarized as follows:

A direct single-electron oxidation of methylenecyclopropanes (MCPs) I (R = H, 2-Me, 3-OMe, 4-F, etc.; R1 = H, 2-Me, 3-Cl, 4-F, etc.) for the rapid construction of 4-aryl-1,2-dihydronaphthalene derivatives II (R2 = H, 5-Me, 6-OMe, 7-F, etc.; R3 = H, F) and III (R4 = R5 = H, F) by merging visible light photoredox catalysis and cobalt catalysis was reported. In MeCN with Et3N·3HF (1.0 equivalent), the fluorination of MCPs I can be realized in the presence of 9-mesityl-10-methylacridinium perchlorate and Co(dmgH)2PyCl, affording fluorinated 4-aryl-1,2-dihydronaphthalene derivatives II (R3 = F) in moderate yields. In MeCN/HFIP (7 : 3), 4-aryl-1,2-dihydronaphthalene derivatives II (R3 = H) and III were obtained in good yields through a metal-catalyzed hydrogen atom transfer process under similar conditions. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Computed Properties of C4H9NO2) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Macsim, Ana-Maria; Georgescu, Emilian; Georgescu, Florentina; Filip, Petru; Nicolescu, Alina; Deleanu, Calin published an article in 2021. The article was titled 《Benzimidazolium salts as starting materials or intermediates in 1,3-dipolar cycloadditions》, and you may find the article in Monatshefte fuer Chemie.Name: 2-Bromoacetamide The information in the text is summarized as follows:

Several new benzimidazolium salts was synthesized and fully characterized by multinuclear NMR spectroscopy. The benzimidazolium salts occurred as intermediates in various 1,3-dipolar cycloadditions and they were also useful as starting materials in such cycloadditions In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics