Month: October 2022

De, Dinesh’s team published research in Chemistry – A European Journal in 2015 | CAS: 64479-78-3

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

In 2015,Chemistry – A European Journal included an article by De, Dinesh; Neogi, Subhadip; Sanudo, E. Carolina; Bharadwaj, Parimal K.. Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide. The article was titled 《Single-Crystal to Single-Crystal Linker Substitution, Linker Place Exchange, and Transmetalation Reactions in Interpenetrated Pillared-Bilayer Zinc(II) Metal-Organic Frameworks》. The information in the text is summarized as follows:

A 2-fold interpenetrated pillared-bilayer framework, {[Zn3(L)2(L2)(DMF)]·(18DMF)(6H2O)}n (1), was synthesized from the ligands tris(4′-carboxybiphenyl)amine (H3L) and 1,2-bis(4-pyridyl)ethylene (L2). The structure contains [Zn3(COO)6] secondary building units (SBUs), in which three ZnII ions are almost linear with carboxylate bridging. This framework undergoes reversible pillar linker substitution reactions at the terminal ZnII centers with three different dipyridyl linkers of different lengths to afford three daughter frameworks, 2-4. Frameworks 2-4 are interconvertible through reversible linker substitution reactions. Also, competitive linker-exchange experiments show preferential incorporation of linker L3 in the parent framework 1. The larger linker L5 does not undergo such substitution reactions and framework 5, which contains this linker, can be synthesized solvothermally as a 2-fold interpenetrated structure. When framework 5 is dipped in a solution of L3 in DMF, linker substitution takes place as before, but linker L5 now moves and diagonally binds two ZnII centers to afford 6 as a nonpenetrated single framework. This linker place exchange reaction is unprecedented. All of these reactions take place in a single-crystal to single-crystal (SC-SC) manner, and were observed directly through x-ray crystallog. Each 3D framework undergoes complete copper(II) transmetalation. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Porala, Subbanarasimhulu’s team published research in ChemistrySelect in 2019 | CAS: 850252-34-5

amides-buliding-blocks(cas:850252-34-5) is one of amino acids. Amino acids are organic compounds that contain both amino and carboxylic acid functional groups Although hundreds of amino acids exist in nature, by far the most prevalent are the alpha-amino acids, which comprise proteins.Synthetic Route of C9H19ClN2O2 Only 22 alpha amino acids appear in the genetic code.

In 2019,ChemistrySelect included an article by Porala, Subbanarasimhulu; Yerrabelly, Jayaprakash Rao; Kasireddy, Venkateshwar Reddy; Yerrabelly, Hemasri; Ghojala, Venkat Reddy; Rebelli, Pradeep. Synthetic Route of C9H19ClN2O2. The article was titled 《New and efficient synthesis of HCV NS3/4 A protease inhibitor Telaprevir》. The information in the text is summarized as follows:

An efficient and improved approach for the synthesis of HCV NS3/4 A (Hepatitis C virus Non-structural protein 3) protease inhibitor, Telaprevir has been developed, which involves the novel synthesis of key intermediates β-amino-α-hydroxy amide (I) and tripeptide acid (II). The synthesis of β-amino-α-hydroxy amide I was designed via the monochloro and dichloro intermediates using the crossed Claisen condensation followed by decarboxylation with good overall yield (29.62%). The tripeptide acid II was developed by the coupling of dipeptide acid with bicyclic nitrile followed by simple chem. conversions in less number of steps with good overall yield (61.2%). After reading the article, we found that the author used (3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride(cas: 850252-34-5Synthetic Route of C9H19ClN2O2)

amides-buliding-blocks(cas:850252-34-5) is one of amino acids. Amino acids are organic compounds that contain both amino and carboxylic acid functional groups Although hundreds of amino acids exist in nature, by far the most prevalent are the alpha-amino acids, which comprise proteins.Synthetic Route of C9H19ClN2O2 Only 22 alpha amino acids appear in the genetic code.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Yahuan’s team published research in Molecular Catalysis in 2021-11-30 | 6961-82-6

Molecular Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, SDS of cas: 6961-82-6.

Liu, Yahuan; Wang, Zheng; Zhao, Ziwei; Gao, Pengxiang; Ma, Ning; Liu, Qingbin published the artcile< Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex>, SDS of cas: 6961-82-6, the main research area is aryl alkyl chloride bromide hydrodehalogenation diphosphine ruthenium catalyst.

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides.

Molecular Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, SDS of cas: 6961-82-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ogita, Haruhisa’s team published research in Bioorganic & Medicinal Chemistry in 2002-06-30 | 5004-88-6

Bioorganic & Medicinal Chemistry published new progress about Cell proliferation. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Ogita, Haruhisa; Isobe, Yoshiaki; Takaku, Haruo; Sekine, Rena; Goto, Yuso; Misawa, Satoru; Hayashi, Hideya published the artcile< Synthesis and structure-activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells>, Computed Properties of 5004-88-6, the main research area is diarylamide urea Tranilast analog preparation vascular cell proliferation.

A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound I was superior to the lead compound, Tranilast, in terms of its potency of inhibitory activity and cell selectivity.

Bioorganic & Medicinal Chemistry published new progress about Cell proliferation. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kumar, Ashwani’s team published research in Life Sciences in 2021-04-15 | 96829-58-2

Life Sciences published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.

Kumar, Ashwani; Chauhan, Shilpi published the artcile< Pancreatic lipase inhibitors: The road voyaged and successes>, HPLC of Formula: 96829-58-2, the main research area is review orlistat antiobesity agent obesity; Antiobesity therapeutics; Orlistat; Pancreatic lipase enzyme; Pancreatic lipase inhibitors; Triacylglycerides.

A review. Human pancreatic lipase (triacylglycerol acyl hydrolase EC3.1.1.3) is the most widely studied member of the human lipase superfamily related to carboxyl esterase. It is secreted from the acinar cell of pancreas and has strong preference for triacylglycerides over cholesterol esters, phospholipids, and galactolipids. Apart from the hydrolysis of triacylglycerides, pancreatic lipase may cause the hydrolysis of retinyl esters in vivo. So, it is very much evidenced that pancreatic lipase with its cofactor colipase has prominent role in efficient digestion of dietary fat. Hence, the modulation of human pancreatic lipase may represent a new insight in the discovery of a number of therapeutics that can inhibit the absorption of fat in body and can be used in obesity and other related metabolic disorders. Even, the only Food and drug administration (FDA) approved antiobesity drug, orlistat, is also an inhibitor of pancreatic lipase. This review summarizes studies about structure, mechanistic approach of pancreatic lipase enzyme while emphasizing on the various synthetic pancreatic lipase inhibitors with their structure activity relationship (SAR).

Life Sciences published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, HPLC of Formula: 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rittner, Roberto’s team published research in Spectroscopy (Amsterdam, Netherlands) in 1991-12-31 | 5326-82-9

Spectroscopy (Amsterdam, Netherlands) published new progress about NMR (nuclear magnetic resonance). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Application In Synthesis of 5326-82-9.

Rittner, Roberto; Canto, Eduardo L.; Grehs, Juares; Zanatta, Nilo published the artcile< Carbon-13 NMR chemical shift substituent effects. α-Mono-substituted N-acetyl-2,2-dimethylaziridines>, Application In Synthesis of 5326-82-9, the main research area is NMR acetyldimethylaziridine.

1H and 13C NMR chem. shifts for N-acetylaziridine, N-acetyl-2-methylaziridine and from some α-monosubstituted-N-acetyl-2,2-dimethylaziridines were recorded. The carbonyl carbon shieldings were compared to the corresponding shieldings of mono-substituted propanones, Me acetates and N,N-diethylacetamides, and were also empirically estimated by Tanaka et al.’s equation. A non-additivity of substituent chem. shifts was observed for the α-methylene carbon, but both the α-methylene carbon as the proton chem. shifts, correlate well with the same nuclei shifts of the three series of monosubstituted carbonyl compounds The Me group’s additivity effects on the remaining carbons are briefly discussed.

Spectroscopy (Amsterdam, Netherlands) published new progress about NMR (nuclear magnetic resonance). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Application In Synthesis of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Qian’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | 6280-57-5

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6280-57-5 belongs to class amides-buliding-blocks, and the molecular formula is C17H35NO, Reference of 6280-57-5.

Zhang, Qian; Hou, Jing; Huang, Yan; Zhan, Le-wu; Li, Bin-dong published the artcile< Visible light-promoted synthesis of ureas and formamides from amines and CO2>, Reference of 6280-57-5, the main research area is urea formamide preparation visible light; amine carbon dioxide carbonylation triphenylphosphine iridium photocatalyst.

A divergent visible-light-induced Ph3P-promoted method for the synthesis of ureas and formamides from amines and CO2 is reported. Without external additions, a range of ureas could be directly accessed under ambient temperature and pressure. Using triisopropylsilanethiol as the hydrogen source, formamides could be produced.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6280-57-5 belongs to class amides-buliding-blocks, and the molecular formula is C17H35NO, Reference of 6280-57-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khalil, Hanan’s team published research in The Annals of pharmacotherapy in 2020-01-20 | 96829-58-2

The Annals of pharmacotherapy published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Application In Synthesis of 96829-58-2.

Khalil, Hanan; Ellwood, Laura; Lord, Heidi; Fernandez, Ritin published the artcile< Pharmacological Treatment for Obesity in Adults: An Umbrella Review.>, Application In Synthesis of 96829-58-2, the main research area is obesity; obesity medications; pharmacotherapy; umbrella review; weight loss.

Objective: To synthesize the evidence from systematic reviews of clinical trials investigating the effectiveness of pharmacological therapies approved by the Australian Therapeutic Goods Administration and the US Food and Drug Administration for the management of obesity in adults. Data Sources: A 3-step literature search of the MEDLINE, EMBASE, CINAHL, and PubMed databases was conducted between March and May 2019. The key terms used were obesity, pharmacological therapy, antiobesity agent, antiobesity medication, weight loss, and systematic review. Study Selection and Data Extraction: Systematic reviews that evaluated the effectiveness of pharmacological therapies for the management of obesity in patients with a body mass index of or greater than 25 kg/m2. Data Synthesis: Nine systematic reviews involving three pharmacotherapies, liraglutide, orlistat, and naltrexone-bupropion were identified. The results indicate that the pharmacotherapies reduced weight when compared with placebo. Orlistat was effective in significantly reducing fasting blood glucose, HbA1c, total cholesterol, triglycerides, and systolic and diastolic blood pressure. All reviews discussed the presence or risk of gastrointestinal adverse effects including diarrhea, vomiting, and nausea related to orlistat and liraglutide. Relevance to Patient Care and Clinical Practice: This umbrella review compares the efficacy and safety of antiobesity medications for reducing weight and a discussion on their weight loss and metabolic control to guide clinicians when prescribing medications for obesity. Conclusions: All pharmacological therapies included in this review are superior to placebo in reducing weight. Clinicians should consider patient comorbidities and risk of adverse events when recommending medications for weight loss.

The Annals of pharmacotherapy published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Application In Synthesis of 96829-58-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Xue-Mei’s team published research in Organic & Biomolecular Chemistry in 2019 | 1524-40-9

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Formula: C6H6FNO2S.

Zhao, Xue-Mei; Huang, En-Ling; Zhu, Yu-Shen; Li, Jing; Song, Bing; Zhu, Xinju; Hao, Xin-Qi published the artcile< Oxidative sulfonamidomethylation of imidazopyridines utilizing methanol as the main C1 source>, Formula: C6H6FNO2S, the main research area is phenyl imidazopyridine methanol sulfamide oxidative sulfonamidomethylation; imidazopyridine methanol amine oxidative aminomethylation.

An efficient one-pot, three-component synthesis of C3 sulfonamidomethylated imidazopyridines was disclosed under metal-free conditions, which utilized the com. available and renewable reagent methanol as the main methylene source. A wide range of substituted imidazopyridines and sulfamides/amines were well tolerated to afford the corresponding products in up to 92% yield. In the isotopic labeling experiment, it was found that a minor part of the methylene also originated from DTBP. Moreover, the radical scavenger reactions were conducted, which suggested that a free-radical mechanism was probably not involved. The current methodol. featured several advantages, including broad substrate scope, good functional group tolerance and high reaction efficiency.

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Formula: C6H6FNO2S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Gaolei’s team published research in Journal of Agricultural and Food Chemistry in 2015-08-12 | 112253-70-0

Journal of Agricultural and Food Chemistry published new progress about Cucumis sativus, disease (root knot nematode, control of). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Wang, Gaolei; Chen, Xiulei; Deng, Yayun; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita>, Recommanded Product: 2-Amino-4-bromobenzamide, the main research area is nematicide benzotriazinone derivative preparation Meloidogyne pest control; 1,2,3-benzotriazin-4-one; 2-cyanoiminothiazolidin-4-one; Meloidogyne incognita; in vivo; nematicide.

A series of novel 1,2,3-benzotriazin-4-one derivatives (I) where R is H, Cl, Br, etc.; and n = 1,2,3,or 4; were synthesized by the reaction of 3-bromoalkyl-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L-1, which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the mol. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L-1 for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.

Journal of Agricultural and Food Chemistry published new progress about Cucumis sativus, disease (root knot nematode, control of). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics