Month: October 2022

Adel Fathy, Shrouk; Ibrahim, Amany K.; Eltamany, Enas E.; Badr, Jihan M. published the artcile< A developed high-performance thin-layer chromatographic method for the determination of orlistat in pharmaceutical preparations>, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate, the main research area is high performance thin layer chromatog orlistat pharmaceutical preparation.

A sensitive and simple high-performance thin-layer chromatog. method is developed and validated according to the International Conference on Harmonisation (ICH) guidelines. The procedure was applied for the estimation of orlistat in different pharmaceutical preparations In the proposed method, thin-layer chromatog. aluminum sheets pre-coated with silica gel were employed as the stationary phase. A number of solvent mixtures were used as the mobile phase for trials to obtain compact bands of orlistat. The solvent mixture consisting of chloroform and methanol (98:2) was found to be the best. The data obtained from the calibration curves of standard orlistat showed a good linear relationship over the concentration range of 1000-3800 ng per band with respect to the area. Scanning was performed at λ = 200 nm, where the correlation coefficient (R2) was 0.970, and the linear regression equation was found to be: y = 4.1419x – 4181.1. After revealing of the spots by anisaldehyde-concentrate sulfuric acid, compact violet bands were obtained and, accordingly, scanning was performed at λ = 600 nm, where a good linear relationship over the concentration range of 600-4000 ng per band with respect to the area was obtained. The correlation coefficient (R2) was 0.991 with a linear regression equation: y = 4.025x – 1159.3. The method was evaluated regarding accuracy, precision, limits of detection and quantification, and robustness. Revealing of the spots by anisaldehyde-concentrate sulfuric acid improved the sensitivity of the method and increased the range within which a linear relationship between concentration and response occurs.

Journal of Planar Chromatography–Modern TLC published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Recommanded Product: (S)-(S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formamido-4-methylpentanoate.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tigori, Mougo Andre; Kouyate, Amadou; Kouakou, Victorien; Niamien, Paulin Marius; Trokourey, Albert published the artcile< Inhibition performance of some sulfonylurea on copper corrosion in nitric acid solution evaluated theoretically by DFT calculations>, Category: amides-buliding-blocks, the main research area is sulfonylurea copper corrosion nitric acid density functional theory calculation.

The theor. study of chlorpropamide, tolazamide and glipizide was carried out by the D. Functional Theory (DFT) at B3LYP/6-31G(d) level. This study made it possible to determine the global reactivity parameters in order to better understand the interactions between the mols. studied and the copper surface. Then, the determination of local reactivity indexes (Fukui functions and dual descriptor) on these mols. resulted in the precision on the most probable centers of nucleophilic and electrophilic attacks within each mol. The results obtained, show that chloropropamide, tolazamide and glipizide can be good inhibitors against copper corrosion. Thus, the mechanism of copper corrosion inhibition of these compounds in nitric acid solution has been explained by means of theor. calculations

Open Journal of Physical Chemistry published new progress about Band gap. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Shikha; Ghosh, Sunil K.; Anitha, M.; Sharma, Joti N. published the artcile< α-Dialkylamino N,N-diisobutylacetamides: a new class of anion exchanger with intramolecular buffering properties>, Reference of 5326-82-9, the main research area is molybdenum dialkylamino diisobutylacetamide anion exchanger intramol buffering.

A new class of ammonium based anion exchangers embedded with a terminal amide group, viz. α-dialkylamino N,N-diisobutylacetamides was designed, synthesized and tested for their ability to extract oxometalate anions from HNO3 medium. As a representative example, the molybdate anion was chosen for the present studies and its extraction behavior was compared with routinely used anion exchangers like Alamine 336, Aliquat 336 and Primene JMT having no amide functionality. A higher %E value for molybdate was observed with α-dialkylamino N,N-diisobutylacetamides compared to Alamine 336, Aliquat 336 and Primene JMT, from the same HNO3 acidity. The presence of amide group in the ligand is the key to the success of extraction from a relatively higher concentration of HNO3 medium. The amide group in the extractant leads to extra acidity through the intramol. buffering effect thus enabling the ligand to extract the molybdate anion at higher acidities. Stoichiometry of the ion pair formed during extraction was ascertained by the slope anal. method. The composition of the complex is (LH)2MoO4·HNO3. FTIR and NMR of the loaded extractant indicated that MoO42- is associated with the ammonium site while binding of HNO3 occurred at the amide group.

RSC Advances published new progress about Amines, C16-22-tert-alkyl Role: RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (Primene JMT). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Reference of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joyce, Paul; Meola, Tahlia R.; Schultz, Hayley B.; Prestidge, Clive A. published the artcile< Biomaterials that regulate fat digestion for the treatment of obesity>, Application of C29H53NO5, the main research area is review biomaterial fat digestion obesity.

Obesity is a rapidly growing concern worldwide, with over one-third of the global population classified as overweight or obese. While significant research has focused on developing new and improved nutritional and dietary approaches for regulating energy intake, there has been little success in overcoming the rising obesity statistics. Consequently, increasing attention is being afforded to designing safe, inexpensive and highly efficacious food-based materials that control fat and carbohydrate bioavailability in order to successfully manage the nutritional value of our food and combat chronic diseases associated with obesity, such as heart disease and diabetes. This review focuses on bioactive and nanostructured materials that have been shown to regulate energy intake by (i) manipulating the fat digestion process, and/or (ii) restricting the absorption of fat digestion products into the systemic bloodstream. The mechanistic approach of such technologies will be discussed in detail, with corresponding preclin. and clin. findings highlighted, to provide insights for the design and development of future anti-obesity therapeutics. Bioactive materials that regulate the fat digestion and absorption process have revealed promising preclin. and clin. findings with respects to modulating calorie intake and thus, weight gain. Insights derived from this review suggest materials that adsorb fat/fat digestion products, rather than interfering with enzyme action, are the most promising therapies, due to their ability to overcome the adverse effects associated with orlistat (the only FDA approved anti-obesity therapy with a localized mechanism of action within the gastrointestinal tract).

Trends in Food Science & Technology published new progress about Homo sapiens. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Application of C29H53NO5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Guozhi; Kertesz, Denis J.; Yang, Minmin; Lin, Xianfeng; Wang, Zhanguo; Li, Wentao; Qiu, Zongxing; Chen, Junli; Mei, Jianghua; Chen, Li; Mirzadegan, Taraneh; Harris, Seth F.; Villasenor, Armando G.; Fretland, Jennifer; Fitch, William L.; Hang, Julie Qi; Heilek, Gabrielle; Klumpp, Klaus published the artcile< Exploration of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses>, Category: amides-buliding-blocks, the main research area is piperidinylpyrimidinamine preparation HIV 1 reverse transcriptase inhibitor; pyrimidinamine piperidinyl preparation structure activity relationship antiviral.

Further investigation on the recently reported N-(piperidin-4-yl)pyrimidin-2-amines I (R = H, 4-Cl, 5-Cl, 6-Cl; R1 = H, 4-SO2NH2, 3-SO2NH2, 2-CONH2, 3-CONH2, 4-CONH2, 3-SO2Me, 3-CN, 3-CO2H; R2 = H, Br, Cl, F, Me, CF3, NH2, NO2; R3 = Me, Cl, OMe, F) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) was carried out. Thus, preparation of a series of N-phenylpiperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Two of the compounds were very potent vs. wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis (no data), structure-activity relationship (SAR), clearance data, and crystallog. evidence for the binding motif were discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Feng; Lu, Lei; Ma, Juan published the artcile< Acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes to quinazolinones in water catalyzed by a water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2>, Computed Properties of 5004-88-6, the main research area is quinazolinone preparation green chem; aminobenzamide aldehyde acceptorless dehydrogenative condensation iridium complex catalyst.

A general and efficient method for the synthesis of quinazolinones, e.g., I via acceptorless dehydrogenative condensation of o-aminobenzamides with aldehydes in water has been accomplished. In the presence of [Cp*Ir(H2O)3][OTf]2, a variety of desirable products were obtained in high yields with high atom economy under environmentally benign conditions. Notably, this research will facilitate the progress of acceptorless dehydrogenative reactions in water catalyzed by water-soluble organometallic complexes.

Organic Chemistry Frontiers published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Gao-Lei; Chen, Xi; Chang, Ya-Ning; Du, Dan; Li, Zhong; Xu, Xiao-Yong published the artcile< Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation>, Safety of 2-Amino-4-bromobenzamide, the main research area is spirocycle indolinone benzotriazinone derivative preparation nematicidal.

To discover new chemotypes of nematicides with proper toxicol. profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 1-(4-(4-oxo-7-methoxylbenzo[d][1,2,3]triazin-3(4H)-yl)butyl)spiro[indoline-3,2′-[1,3]dioxolan]-2-one and 1-(4-(4-oxo-7-nitrobenzo[d][1,2,3]triazin-3(4H)-yl)butyl)spiro[indoline-3,2′-[1,3]dioxolan]-2-one displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.

Chinese Chemical Letters published new progress about Nematocides. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Safety of 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yen, Fu-Shun; Lai, Jung-Nien; Wei, James Cheng-Chung; Chiu, Lu-Ting; Hwu, Chii-Min; Hou, Ming-Chih; Hsu, Chih-Cheng published the artcile< Sulfonylureas may be useful for glycemic management in patients with diabetes and liver cirrhosis>, Electric Literature of 94-20-2, the main research area is sulfonylurea antidiabetic agent hyperglycemia diabetes liver cirrhosis.

This study aimed to investigate the long-term outcomes of sulfonylurea (SU) use in patients with T2DM and compensated liver cirrhosis. From Jan. 1, 2000, to Dec. 31, 2012, we selected the data of 3781 propensity-score-matched SU users and nonusers from Taiwan’s National Health Insurance Research Database. The mean follow-up time for this study was 5.74 years. Cox proportional hazards models with robust sandwich standard error estimates were used to compare the risks of main outcomes between SU users and nonusers. The incidence of mortality during follow-up was 3.24 and 4.09 per 100 person-years for SU users and nonusers, resp. The adjusted hazard ratios and 95% confidence intervals for all-cause mortality, major cardiovascular events, and decompensated cirrhosis in SU users relative to SU nonusers were 0.79 (0.71-0.88), 0.69 (0.61-0.80), and 0.82 (0.66-1.03), resp. The SU-associated lower risks of death and cardiovascular events seemed to have a dose-response trend. This population-based cohort study demonstrated that SU use was associated with lower risks of death and major cardiovascular events compared with SU non-use in patients with T2DM and compensated liver cirrhosis. SUs may be useful for glycemic management for patients with liver cirrhosis.

PLoS One published new progress about Angiotensin-converting enzyme inhibitors. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Johnson, Adiv A. published the artcile< Lipid Hydrolase Enzymes: Pragmatic Prolongevity Targets for Improved Human Healthspan?>, Product Details of C29H53NO5, the main research area is lipase lipid hydrolase lifespan aging; aging; healthspan; lifespan; lipase; lipid hydrolase; rejuvenation.

Compelling evidence suggests that lipid metabolism, which plays critical roles in fat storage, cell membrane maintenance, and cell signaling, is intricately linked to aging. Lipid hydrolases are important enzymes that catalyze the hydrolysis of more complex lipids into simpler lipids. Diverse interventions targeting lipid hydrolases can prolong or shorten life in model organisms. For example, the genetic removal of or RNAi knockdown against a phospholipase can reduce lifespan in Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. The removal of lysosomal acid lipase results in premature death in mice, while its overexpression in nematodes generates lean, long-lived individuals. The overexpression or inhibition of diacylglycerol lipase leads to enhanced or reduced longevity, resp., in both worms and flies. Lifespan can also be extended by knocking down triacylglycerol lipases in yeast, overexpressing fatty acid amide hydrolase in worms, or removing hepatic lipase in a mouse model of coronary disease. Conversely, flies lacking the triacylglycerol lipase Brummer are obese and short lived. Linking sphingolipids and aging, removing the sphingomyelinase inositol phosphosphingolipid phospholipase shortens chronol. lifespan in Saccharomyces cerevisiae, while inhibiting an acid sphingomyelinase in worms or inactivating alk. ceramidase in flies extends lifespan. The clin. potential of manipulating these enzymes is highlighted by the FDA-approved obesity drug orlistat, which is an inhibitor of pancreatic and hepatic lipases that induces weight loss and improves insulin/glucose homeostasis. Addnl. research is warranted to better understand how these lipid hydrolases impact aging and to determine if clin. interventions targeting them are capable of improving human healthspan.

Rejuvenation Research published new progress about Caenorhabditis elegans. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Product Details of C29H53NO5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Abdel-Salam, Omar M. E.; Sleem, Amany A.; Youness, Eman R.; Morsy, Fatma A. published the artcile< Exacerbation of toluene's neuro- and hepato-toxicity by amiodarone or chlorpropamide: involvement of oxidative stress>, Name: 4-Chloro-N-(propylcarbamoyl)benzenesulfonamide, the main research area is amiodarone chlorpropamide neuroprotectant neurotoxicity hepatotoxicity.

Volatile solvent abuse is an important health problem and results in serious injury to the central nervous system. Neuroprotective effects were reported for the sulfonylurea group of drugs and for the anti-arrhythmic agent amiodarone, and these drugs have a K+ channel-blocking effect. The K+ channels are of interest for their ability to modulate brain damage. The aim of this study was to investigate the effect of amiodarone and chlorpropamide on the development of oxidative stress and brain and liver damage induced by toluene injection in rats. Toluene (900 mg/kg) was i.p. (i.p.) administered alone or in combination with amiodarone or chlorpropamide (18 or 36 mg/kg, orally) once a day for 2 consecutive days. The brain and liver content of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO), and the activity of paraoxonase-1 (PON-1) were determined In addition, butyrylcholinesterase (BChE) and the concentration of the anti-apoptotic protein (Bcl-2) were determined in brain homogenates. Histopathol. examination of brain and liver sections was also performed. Results showed that compared to controls, toluene resulted in increased oxidative stress in the brain and liver tissues. MDA and NO concentrations were markedly raised along with decreased levels of GSH and PON-1 activity. Toluene also inhibited BChE activity and decreased Bcl-2 level in the brain tissue. The biochem. changes induced by toluene were aggravated by the administration of either amiodarone or chlorpropamide. Rats treated with toluene exhibited dead neurons, perineuronal vacuolations, infiltrative cells, glial cells, and degeneration of some Purkinje cells. In the liver, massive hepatic inflammatory infiltrate, hemorrhage, vacuolar degeneration, apoptosis, and degeneration of hepatocytes were observed The co-administration of either amiodarone or chlorpropamide caused dose-dependent exacerbation of the toluene-induced pathol. changes. These findings suggest the involvement of oxidative stress in the neuro- and hepato-toxicity by toluene and imply a greater toxicity in toluene abusers treated with either amiodarone or chlorpropamide.

Reactive Oxygen Species published new progress about Bcl-2 proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Name: 4-Chloro-N-(propylcarbamoyl)benzenesulfonamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics